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Protein Overview: EMX2_MOUSE

General Information:
Name(s) found: EMX2_MOUSE [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Homeobox protein EMX2 OS=Mus musculus GN=Emx2 PE=2 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 253 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: multicellular organismal development [IEA]
    neuron differentiation [IMP]
    cell proliferation in forebrain [IMP]
    anterior/posterior pattern formation [IGI][IMP]
    forebrain cell migration [IMP]
    regulation of transcription, DNA-dependent [IEA]
    brain development [IMP]
    regulation of transcription [IEA]
    dentate gyrus development [IMP]
    cerebral cortex regionalization [IGI]
    forebrain development [IGI][IMP]
    response to drug [IDA]
    regulation of gene expression [IMP]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [IEA]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA  60
   61 GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSLHSPHPLF ASQQRDPSTF 120
  121 YPWLIHRYRY LGHRFQGNDT SPESFLLHNA LARKPKRIRT AFSPSQLLRL EHAFEKNHYV 180
  181 VGAERKQLAH SLSLTETQVK VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK 240
  241 QASPEEIDVT SDD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] deduced N/A No confident structure predictions are available.
    2 View Details [137..253] PSI-BLAST 25.69897 Ultrabithorax (ubx) homeodomain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.67711146264366 bayes_pls_golite062009
  • DNA binding
    		•  4.26679916438424 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.10991419309805 bayes_pls_golite062009
  • transcription factor activity
    		•  3.74788993580019 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.16521751467289 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.96364983538233 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.79427849359671 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6126228397074 bayes_pls_golite062009
  • transcription factor binding
    		•  1.32991027110041 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.9526286147364 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • chromatin binding
    		•  0.775421813815509 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.71989890364863 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0615820877359203 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle