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Protein Overview: TLX2_MOUSE

General Information:
Name(s) found: TLX2_MOUSE [Swiss-Prot]
Description(s) found:
Found 26 descriptions.
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  • T-cell leukemia homeobox protein 2 OS=Mus musculus GN=Tlx2 PE=2 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    cytoplasm [IDA]
    Biological Process: enteric nervous system development [IMP]
    negative regulation of dendrite morphogenesis [IDA]
    multicellular organismal development [IEA]
    regulation of transcription, DNA-dependent [IEA]
    mesoderm formation [IMP]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [UNKNOWN]
    protein binding [IPI]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPAVLAAHH LPHHEPISFG IDQILSGPEP PGGGLGPGQS GQSHGESAAF SSGFHGASGY  60
   61 APAGSLASLP RGSGVGPGGV IRVPAHRPLP VPPPSGAAPA VPGPSGLGGA GGLAGLTFPW 120
  121 MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 180
  181 YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 240
  241 RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] MSA 2.011995 View MSA. No confident structure predictions are available.
    2 View Details [107..284] PSI-BLAST 26.0 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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