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Protein Overview: VAX2_MOUSE

General Information:
Name(s) found: VAX2_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|6755957|ref|NP_036042.1| ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI NR]
  • gi|6649918|gb|AAF21632.1|AF028715_1 ventral retina homeodomain protein [Mus musculus] [NCBI NR]
  • gi|62901394|sp|Q9WTP9.1|VAX2_MOUSE RecName: Full=Ventral anterior homeobox 2; AltName: Full=Ventral retina homeodomain protein [NCBI NR]
  • gi|5912493|emb|CAB56169.1| Vax2 protein [Mus musculus] [NCBI NR]
  • gi|4589696|dbj|BAA76867.1| homeobox protein [Mus musculus] [NCBI NR]
  • gi|148666682|gb|EDK99098.1| ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI NR]
  • gi|146141241|gb|AAH90635.1| Ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI NR]
  • gi|109732875|gb|AAI16391.1| Ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI NR]
  • gi|109732632|gb|AAI16390.1| Ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI NR]
  • Ventral anterior homeobox 2 OS=Mus musculus GN=Vax2 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):6-84175105 Homeobox protein [hmr_yeast5_DM3-1_pombe.fasta]
  • ventral anterior homeobox containing gene 2 [HMR_022704-rand.fasta]
  • ventral anterior homeobox containing gene 2 [Mus musculus]gi|6649918|gb|AAF21632.1| ventral retina homeodomain protein [Mus musculus]gi|5912493|emb|CAB56169.1| Vax2 protein [Mus musculus]gi|4589696|dbj|BAA76867.1| homeobox protein [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • Ventral anterior homeobox 2 [ipi.MOUSE.v3.06.fasta]
  • Tax_Id=10090 Ventral anterior homeobox 2 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_011912) ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ventral anterior homeobox containing gene 2 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Ventral anterior homeobox 2 (Ventral retina homeodomain protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Ventral anterior homeobox containing gene 2 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Vax2 protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • homeobox protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ventral retina homeodomain protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 HOMEOBOX PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Vax2 Ventral anterior homeobox 2 [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Vax2 Ventral anterior homeobox 2 ENSMUSG00000034777 IPI00123684 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • ventral anterior homeobox 2 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00123684.1|SWISS-PROT:Q9WTP9|TREMBL:Q14B19|ENSEMBL:ENSMUSP00000035976|REFSEQ:NP_036042 Tax_Id=10090 Gene_Symbol=Vax2 Ventral anterior homeobox 2 [ipi.MOUSE.fasta.20090209]
  • Ventral anterior homeobox 2 OS=Mus musculus GN=Vax2 [011711_HMR.fasta]
  • sp|Q9WTP9|VAX2_MOUSE Ventral anterior homeobox 2 OS=Mus musculus GN=Vax2 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
  • tr|Q14B19|Q14B19_MOUSE Ventral anterior homeobox containing gene 2 OS=Mus musculus GN=Vax2 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
  • Ventral anterior homeobox containing gene 2 OS=Mus musculus GN=Vax2 PE=2 SV=1 [mouse-uniprot-290313-contam.fasta]
  • Isoform of Q9WTP9, Ventral anterior homeobox 2 OS=Mus musculus GN=Vax2 PE=1 SV=1 [MOUSE.fasta.20160308]
    • Organism: Mus musculus
    Length: 292 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGI]
    transcription [IEA]
    multicellular organismal development [IEA]
    embryonic eye morphogenesis [IDA][IMP]
    retina development in camera-type eye [IDA]
    axonogenesis [IMP]
    camera-type eye development [IGI]
    regulation of transcription, DNA-dependent [IEA]
    dorsal/ventral axis specification [IMP]
    regulation of transcription [IEA]
    Molecular Function: DNA binding [IEA]
    chromatin DNA binding [IDA]
    transcription factor activity [IEA]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDGGAERDR GPKRREEPGG RSGRHGEHRG AEDLRADTGS ASPREIAGTS ASSPAGSRES  60
   61 GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD RPKRTRTSFT AEQLYRLEME 120
  121 FQRCQYVVGR ERTELARQLN LSETQVKVWF QNRRTKQKKD QSRDLEKRAS SSASEAFATS 180
  181 NVLRLLEQGR LLSVPRAPSL LALTPGLPGL PASHRGTSLV DPRNSSPRLN PMPSASASSP 240
  241 LPPPLPAICF SSAPLLDLPA GYKLGSSAFE PYSRLEQQKV GSPGQSDKKA DI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] PSI-BLAST 23.522879 Homeobox protein hox-b1
    2 View Details [166..292] MSA 8.986997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle