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View Structure Prediction Details

Protein: VAX2_MOUSE
Organism: Mus musculus
Length: 292 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAX2_MOUSE.

Description E-value Query
Range
Subject
Range
VAX2_RAT - Ventral anterior homeobox 2 OS=Rattus norvegicus GN=Vax2 PE=2 SV=1
165.0 [0..1] [292..1]
gi|109103296 - gi|109103296|ref|XP_001100565.1| PREDICTED: ventral anterior homeobox 2 [Macaca mulatta]
149.0 [0..1] [275..1]
gi|30584433, gi|... - gi|60653237|gb|AAX29313.1| ventral anterior homeobox 2 [synthetic construct], gi|60653235|gb|AAX2931...
148.0 [0..1] [284..1]
VAX2 - ventral anterior homeobox 2
gi|60656287 - gi|60656287|gb|AAX32707.1| ventral anterior homeobox 2 [synthetic construct]
148.0 [0..1] [284..1]
gi|114578030 - gi|114578030|ref|XP_525781.2| PREDICTED: ventral anterior homeobox 2 [Pan troglodytes]
147.0 [0..1] [284..1]
gi|3402201 - gi|3402201|emb|CAA16493.1| PAX6 [Takifugu rubripes]
136.0 [0..3] [282..138]
gi|76628969 - gi|76628969|ref|XP_589627.2| PREDICTED: similar to Ventral anterior homeobox 2 [Bos taurus]
133.0 [0..1] [290..1]
gi|2696969 - gi|2696969|dbj|BAA24022.1| PAX6 LS [Cynops pyrrhogaster]
132.0 [0..3] [255..149]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDGGAERDR GPKRREEPGG RSGRHGEHRG AEDLRADTGS ASPREIAGTS ASSPAGSRES  60
   61 GGDSDGQQAL GETDHCRRIL VRDAKGTIRE IVLPKGLDLD RPKRTRTSFT AEQLYRLEME 120
  121 FQRCQYVVGR ERTELARQLN LSETQVKVWF QNRRTKQKKD QSRDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [166-292]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKRASSSASE AFATSNVLRL LEQGRLLSVP RAPSLLALTP GLPGLPASHR GTSLVDPRNS  60
   61 SPRLNPMPSA SASSPLPPPL PAICFSSAPL LDLPAGYKLG SSAFEPYSRL EQQKVGSPGQ 120
  121 SDKKADI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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