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Protein Overview: H2AX_MOUSE

General Information:
Name(s) found: H2AX_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|7106331|ref|NP_034566.1| H2A histone family, member X [Mus musculus] [NCBI NR]
  • gi|515879|emb|CAA84585.1| histone H2A.X [Mus musculus] [NCBI NR]
  • gi|51142|emb|CAA41099.1| histone H2A.X [Mus musculus] [NCBI NR]
  • pir||I48406 histone H2A.X - mouse [NCBI NR]
  • gi|16307580|gb|AAH10336.1| H2A histone family, member X [Mus musculus] [NCBI NR]
  • gi|148693632|gb|EDL25579.1| mCG10709 [Mus musculus] [NCBI NR]
  • gi|13529488|gb|AAH05468.1| H2A histone family, member X [Mus musculus] [NCBI NR]
  • gi|121993|sp|P27661.2|H2AX_MOUSE RecName: Full=Histone H2A.x; Short=H2a/x [NCBI NR]
  • Histone H2AX OS=Mus musculus GN=H2afx PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):9-44380801 H2A histone family, member X [hmr_yeast5_DM3-1_pombe.fasta]
  • H2A histone family, member X; histone 5 protein 2ax [HMR_022704-rand.fasta]
  • H2A histone family, member X [Mus musculus]gi|13529488|gb|AAH05468.1| H2A histone family, member X [Mus musculus]gi|16307580|gb|AAH10336.1| H2A histone family, member X [Mus musculus]gi|121993|sp|P27661|H2AX_MOUSE Histone H2A.Xgi|515879|emb|CAA84585.1 [nrdb_11152004_Chlamydomonas]
  • (NM_010436) H2A histone family, member X; histone 5 protein 2ax [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • H2A histone family, member X [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Histone H2A.x (H2a/x) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mCG10709 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • histone H2A.X [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 H2A HISTONE FAMILY, MEMBER X [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=H2afx Histone H2A.x [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=H2afx Histone H2A.x ENSMUSG00000049932 IPI00230264 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • histone H2A.x [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00230264.5|SWISS-PROT:P27661|ENSEMBL:ENSMUSP00000051432|REFSEQ:NP_034566 Tax_Id=10090 Gene_Symbol=H2afx Histone H2A.x [ipi.MOUSE.fasta.20090209]
  • Histone H2A.x OS=Mus musculus GN=H2afx [011711_HMR.fasta]
  • H2A histone family, member X; histone 5 protein 2ax [Mus musculus] [H3-CATD_Contrast.fasta]
  • Histone H2A.x OS=Mus musculus GN=H2afx PE=1 SV=2 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • sp|P27661|H2AX_MOUSE Histone H2A.x OS=Mus musculus GN=H2afx PE=1 SV=2 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 143 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT  60
   61 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 120
  121 SSATVGPKAP AVGKKASQAS QEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..143] PSI-BLAST 45.69897 No description for 2f8nK was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.76324070757253 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.03586371237592 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.897625638883141 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.86666384236806 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.322861678821436 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.322861678821436 bayes_pls_golite062009
  • histone binding
    		•  0.218942897869955 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0885263144317296 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle