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View Structure Prediction Details

Protein: H2AX_MOUSE
Organism: Mus musculus
Length: 143 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for H2AX_MOUSE.

Description E-value Query
Range		 Subject
Range
gi|68432331 - gi|68432331|ref|XP_690287.1| PREDICTED: similar to ReO_6 [Danio rerio]
 208.0 [0..1] [127..288]
gi|73955042 - gi|73955042|ref|XP_853256.1| PREDICTED: similar to Histone H2A.x (H2a/x) [Canis familiaris]
 198.0 [0..3] [143..102]
gi|55637423 - gi|55637423|ref|XP_522264.1| PREDICTED: similar to Histone H2A.x (H2a/x) [Pan troglodytes]
H2AFX - H2A histone family, member X
gi|109108926 - gi|109108926|ref|XP_001102040.1| PREDICTED: similar to Histone H2A.x (H2a/x) isoform 2 [Macaca mulat...
ENSCJAT00000043996 - null
gi|208968471 - gi|208968471|dbj|BAG74074.1| H2A histone family, member X [synthetic construct]
ENSOCUP00000024225 - pep:novel scaffold:oryCun2:GL018823:567148:567579:-1 gene:ENSOCUG00000015180 transcript:ENSOCUT00000...
 192.0 [0..1] [143..1]
gi|76635357, gi|... - gi|76635357|ref|XP_610233.2| PREDICTED: similar to Histone H2AFX (Histone H2A.X) (H2a/x) [Bos taurus...
 192.0 [0..1] [143..1]
gi|109483394, gi... - gi|157817664|ref|NP_001102761.1| H2A histone family, member X [Rattus norvegicus], gi|149041453|gb|E...
 191.0 [0..1] [143..1]
gi|50728596 - gi|50728596|ref|XP_416195.1| PREDICTED: similar to histone 2, H2ac [Gallus gallus]
 189.0 [0..1] [129..222]

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Predicted Domain #1
Region A:
Residues: [1-143] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGRGKTGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGHY AERVGAGAPV YLAAVLEYLT  60
   61 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGG VTIAQGGVLP NIQAVLLPKK 120
  121 SSATVGPKAP AVGKKASQAS QEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.69897
Match: 2f8nK
Description: No description for 2f8nK was found.

Predicted functions:

Term Confidence Notes
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.76324070757253 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transcription repressor activity 2.3574713307436 bayes_pls_golite062009
transcription corepressor activity 1.30859203490073 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
centromeric DNA binding 1.03586371237592 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
DNA polymerase activity 0.897625638883141 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.86666384236806 bayes_pls_golite062009
histone acetyltransferase activity 0.322861678821436 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.322861678821436 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
transcription coactivator activity 0.0885263144317296 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle