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Protein Overview: EXOS1_MOUSE

General Information:
Name(s) found: EXOS1_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|28380043|sp|Q9DAA6.1|EXOS1_MOUSE RecName: Full=3'-5' exoribonuclease CSL4 homolog; AltName: Full=Exosome component 1 [NCBI NR]
  • gi|22267446|ref|NP_079920.1| exosome component 1 [Mus musculus] [NCBI NR]
  • gi|19353756|gb|AAH24423.1| Exosome component 1 [Mus musculus] [NCBI NR]
  • gi|148709921|gb|EDL41867.1| exosome component 1, isoform CRA_b [Mus musculus] [NCBI NR]
  • gi|12838900|dbj|BAB24368.1| unnamed protein product [Mus musculus] [NCBI NR]
  • Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 PE=1 SV=1 [Swiss-Prot]
  • (Q9DAA6) 3'-5' exoribonuclease CSL4 homolog (EC 3.1.13.-) (Exosome component 1) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):19-41509078 Splice isoform 1 of Q9DAA6 3'-5' exoribonuclease CSL4 homolog [hmr_yeast5_DM3-1_pombe.fasta]
  • exosome component 1 [HMR_022704-rand.fasta]
  • exosome component 1 [Mus musculus]gi|19353756|gb|AAH24423.1| Exosome component 1 [Mus musculus]gi|28380043|sp|Q9DAA6|CSL4_MOUSE 3'-5' exoribonuclease CSL4 homolog (Exosome component 1)gi|12838900|dbj|BAB24368.1| unnamed protein product [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • Splice Isoform 1 of 3'-5' exoribonuclease CSL4 homolog [ipi.MOUSE.v3.06.fasta]
  • Tax_Id=10090 Splice Isoform 1 of 3'-5' exoribonuclease CSL4 homolog [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_025644) RIKEN cDNA 2610104C07 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • exosome component 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • 3'-5' exoribonuclease CSL4 homolog (Exosome component 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • exosome component 1, isoform CRA_b [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Exosome component 1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 SPLICE ISOFORM 1 OF 3'-5' EXORIBONUCLEASE CSL4 HOMOLOG [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc1 Isoform 1 of 3'-5' exoribonuclease CSL4 homolog [mouse-ipi-250309-contam.fasta]
  • exosome component 1 isoform 1 [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc1 Isoform 1 of 3'-5' exoribonuclease CSL4 homolog ENSMUSG00000034321 IPI00118360 IPI00283868 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • 3'-5' exoribonuclease CSL4 homolog isoform 1 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00118360.1|SWISS-PROT:Q9DAA6-1|ENSEMBL:ENSMUSP00000074756|REFSEQ:NP_079920 Tax_Id=10090 Gene_Symbol=Exosc1 Isoform 1 of 3'-5' exoribonuclease CSL4 homolog [ipi.MOUSE.fasta.20090209]
  • Isoform 1 of 3'-5' exoribonuclease CSL4 homolog OS=Mus musculus GN=Exosc1 [011711_HMR.fasta]
  • 3'-5' exoribonuclease CSL4 homolog OS=Mus musculus GN=Exosc1 PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta]
  • Isoform 1 of Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 [122011_mus.fasta]
  • Tax_Id=10090 Gene_Symbol=Exosc1 Isoform 1 of Exosome complex component CSL4 [EBI-IPI_mouse_2_08-18-2011_reversed.fasta]
  • Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 PE=2 SV=1 [uniprot-mouse-120502.fasta]
  • sp|Q9DAA6|EXOS1_MOUSE Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 PE=2 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 195 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    nucleolus [UNKNOWN]
    exosome (RNase complex) [UNKNOWN]
    Biological Process: RNA processing [UNKNOWN]
    rRNA processing [IEA]
    Molecular Function: RNA binding [IEA]
    exonuclease activity [IEA]
    nuclease activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPPVRYCIP GERLCNLEEG SPGSGTYTRH GYIFSSLAGC LMKTSENGAV PVVSVMRETE  60
   61 SQLLPDVGAV VTCKVSSINS RFAKVHILYV GSTPLKNAFR GTIRKEDIRA TEKDKVEIYK 120
  121 SFRPGDIVLA KVISLGDAQS NYLLTTAENE LGVVVAHSES GVQMVPISWC EMQCPKTHTK 180
  181 EFRKVARVQP EFLQT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] PSI-BLAST 46.69897 No description for 2nn6I was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonuclease activity
    		•  7.42330864261751 bayes_pls_golite062009
  • exoribonuclease activity
    		•  6.76241588209982 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  6.73428326869965 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  5.13367897180134 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  4.51084463039261 bayes_pls_golite062009
  • structural molecule activity
    		•  4.29692945022158 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  3.51306349336452 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.194200758646 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  3.07263153665399 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.73968547121328 bayes_pls_golite062009
  • DNA binding
    		•  2.71213098011194 bayes_pls_golite062009
  • exonuclease activity
    		•  2.66053639652924 bayes_pls_golite062009
  • binding
    		•  2.63617204791771 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • exoribonuclease II activity
    		•  1.18248519339188 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • hydrolase activity
    		•  0.724860465280978 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • translation regulator activity
    		•  0.22908707234671 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.179682348023561 bayes_pls_golite062009
  • catalytic activity
    		•  0.161830442565647 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.150235510823939 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • protein binding
    		•  0.0528188351789111 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle