Protein Overview: TLR3_MOUSE

General Information:
Name(s) found:	TLR3_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|31543872\|ref\|NP_569054.2\| toll-like receptor 3 [Mus musculus] [NCBI NR] gi\|26350891\|dbj\|BAC39082.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|20140736\|sp\|Q99MB1.2\|TLR3_MOUSE RecName: Full=Toll-like receptor 3; AltName: CD_antigen=CD283; Flags: Precursor [NCBI NR] gi\|16589082\|gb\|AAL27007.1\| toll-like receptor 3 [Mus musculus] [NCBI NR] gi\|148703602\|gb\|EDL35549.1\| toll-like receptor 3, isoform CRA_b [Mus musculus] [NCBI NR] Toll-like receptor 3 OS=Mus musculus GN=Tlr3 PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):8-44408610 Toll-like receptor 3 precursor [hmr_yeast5_DM3-1_pombe.fasta] toll-like receptor 3 [HMR_022704-rand.fasta] Toll-like receptor 3 precursor [ipi.MOUSE.v3.06.fasta] toll-like receptor 3 [Mus musculus]gi\|16589082\|gb\|AAL27007.1\| toll-like receptor 3 [Mus musculus]gi\|26350891\|dbj\|BAC39082.1\| unnamed protein product [Mus musculus]gi\|20140736\|sp\|Q99MB1\|TLR3_MOUSE Toll-like receptor 3 precursor [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Toll-like receptor 3 precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] toll-like receptor 3 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Toll-like receptor 3 precursor (CD283 antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] toll-like receptor 3, isoform CRA_b [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 TOLL-LIKE RECEPTOR 3 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Tlr3 Toll-like receptor 3 [mouse-ipi-250309-contam.fasta] toll-like receptor 3 precursor [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Tlr3 Toll-like receptor 3 precursor [ipi.MOUSE_jw_12may08.contam.fasta] Tax_Id=10090 Gene_Symbol=Tlr3 Toll-like receptor 3 precursor ENSMUSG00000031639 IPI00320618 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00320618.1\|SWISS-PROT:Q99MB1\|TREMBL:Q3TM31;Q499F3;Q8C2X8\|ENSEMBL:ENSMUSP00000034056\|REFSEQ:NP_569054 Tax_Id=10090 Gene_Symbol=Tlr3 Toll-like receptor 3 [ipi.MOUSE.fasta.20090209] Toll-like receptor 3 OS=Mus musculus GN=Tlr3 [011711_HMR.fasta] sp\|Q99MB1\|TLR3_MOUSE Toll-like receptor 3 OS=Mus musculus GN=Tlr3 PE=1 SV=2 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	905 amino acids
Gene Ontology:
Cellular Component:	endosome [IEA] membrane [IEA] integral to membrane [IEA] endoplasmic reticulum [IEA] intrinsic to membrane [IEA]
Biological Process:	signal transduction [IEA] microglial cell activation during immune response [UNKNOWN] positive regulation of I-kappaB kinase/NF-kappaB cascade [IDA][IGI][IMP] response to dsRNA [UNKNOWN] defense response [IMP] response to virus [IMP] positive regulation of NF-kappaB transcription factor activity [IMP] positive regulation of interferon-beta biosynthetic process [ISS] toll-like receptor signaling pathway [UNKNOWN] inflammatory response [IEA] positive regulation of interleukin-12 production [IDA] innate immune response [IEA][TAS] response to exogenous dsRNA [IMP] positive regulation of JNK cascade [IDA] positive regulation of interferon-beta production [IDA] pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity [UNKNOWN] defense response to virus [TAS] positive regulation of tumor necrosis factor production [IDA][IMP] positive regulation of interleukin-6 production [IDA][IMP] positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA] positive regulation of chemokine biosynthetic process [IMP]
Molecular Function:	RNA binding [IEA] transmembrane receptor activity [IEA] protein binding [IEA][IPI] double-stranded RNA binding [UNKNOWN] receptor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGCSSYLMY SFGGLLSLWI LLVSSTNQCT VRYNVADCSH LKLTHIPDDL PSNITVLNLT  60
   61 HNQLRRLPPT NFTRYSQLAI LDAGFNSISK LEPELCQILP LLKVLNLQHN ELSQISDQTF 120
  121 VFCTNLTELD LMSNSIHKIK SNPFKNQKNL IKLDLSHNGL SSTKLGTGVQ LENLQELLLA 180
  181 KNKILALRSE ELEFLGNSSL RKLDLSSNPL KEFSPGCFQT IGKLFALLLN NAQLNPHLTE 240
  241 KLCWELSNTS IQNLSLANNQ LLATSESTFS GLKWTNLTQL DLSYNNLHDV GNGSFSYLPS 300
  301 LRYLSLEYNN IQRLSPRSFY GLSNLRYLSL KRAFTKQSVS LASHPNIDDF SFQWLKYLEY 360
  361 LNMDDNNIPS TKSNTFTGLV SLKYLSLSKT FTSLQTLTNE TFVSLAHSPL LTLNLTKNHI 420
  421 SKIANGTFSW LGQLRILDLG LNEIEQKLSG QEWRGLRNIF EIYLSYNKYL QLSTSSFALV 480
  481 PSLQRLMLRR VALKNVDISP SPFRPLRNLT ILDLSNNNIA NINEDLLEGL ENLEILDFQH 540
  541 NNLARLWKRA NPGGPVNFLK GLSHLHILNL ESNGLDEIPV GVFKNLFELK SINLGLNNLN 600
  601 KLEPFIFDDQ TSLRSLNLQK NLITSVEKDV FGPPFQNLNS LDMRFNPFDC TCESISWFVN 660
  661 WINQTHTNIS ELSTHYLCNT PHHYYGFPLK LFDTSSCKDS APFELLFIIS TSMLLVFILV 720
  721 VLLIHIEGWR ISFYWNVSVH RILGFKEIDT QAEQFEYTAY IIHAHKDRDW VWEHFSPMEE 780
  781 QDQSLKFCLE ERDFEAGVLG LEAIVNSIKR SRKIIFVITH HLLKDPLCRR FKVHHAVQQA 840
  841 IEQNLDSIIL IFLQNIPDYK LNHALCLRRG MFKSHCILNW PVQKERINAF HHKLQVALGS 900
  901 RNSAH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: TLR3_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: