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Protein Overview: NTH1_MOUSE, NTHL...

General Information:
Name(s) found: NTHL1_MOUSE [Swiss-Prot]
NTH1_MOUSE [Swiss-Prot]
Description(s) found:
Found 32 descriptions.
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  • Endonuclease III-like protein 1 OS=Mus musculus GN=Nthl1 PE=2 SV=1 [Swiss-Prot]
  • (O35980) Endonuclease III-like protein 1 (EC 4.2.99.18) [Swiss-Prot]
    • Organism: Mus musculus
    Length: 300 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    mitochondrion [IDA]
    Biological Process: DNA repair [TAS]
    base-excision repair [IEA]
    nucleotide-excision repair, DNA incision, 5'-to lesion [IDA]
    metabolic process [IEA]
    response to DNA damage stimulus [IEA]
    Molecular Function: DNA binding [IEA]
    metal ion binding [IEA]
    catalytic activity [IEA]
    endonuclease activity [IEA]
    lyase activity [IEA]
    DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
    DNA N-glycosylase activity [IDA]
    4 iron, 4 sulfur cluster binding [IEA]
    iron-sulfur cluster binding [IEA]
    hydrolase activity [IEA]
    hydrolase activity, acting on glycosyl bonds [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSGVRMVTR SRSRATRIAS EGCREELAPR EAAAEGRKSH RPVRHPRRTQ KTHVAYEAAN  60
   61 GEEGEDAEPL KVPVWEPQNW QQQLANIRIM RSKKDAPVDQ LGAEHCYDAS APPKVRRYQV 120
  121 LLSLMLSSQT KDQVTAGAMQ RLRARGLTVE SILQTDDDTL GRLIYPVGFW RNKVKYIKQT 180
  181 TAILQQRYEG DIPASVAELV ALPGVGPKMA HLAMAVAWGT ISGIAVDTHV HRIANRLRWT 240
  241 KKMTKTPEET RKNLEEWLPR VLWSEVNGLL VGFGQQICLP VHPRCQACLN KALCPAAQDL 300
  301

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..300] PSI-BLAST 58.09691 REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.8124964619976 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.26870112679392 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • hydrolase activity
    		•  2.39042189031819 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.18053745735048 bayes_pls_golite062009
  • catalytic activity
    		•  2.13345932727422 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.00388798014411 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • DNA binding
    		•  1.44394874535958 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36800347239439 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  1.2016453685638 bayes_pls_golite062009
  • binding
    		•  1.15752946565805 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.85419760398899 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.57099109384393 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.493252955870142 bayes_pls_golite062009
  • protein binding
    		•  0.0921713980805489 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle