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Protein Overview: TDGF1_MOUSE

General Information:
Name(s) found: TDGF1_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|6755756|ref|NP_035692.1| teratocarcinoma-derived growth factor [Mus musculus] [NCBI NR]
  • gi|402715|gb|AAA37459.1| cripto [NCBI NR]
  • pir||I49612 teratocarcinoma-derived growth factor - mouse [NCBI NR]
  • gi|1706128|sp|P51865.1|TDGF1_MOUSE RecName: Full=Teratocarcinoma-derived growth factor; AltName: Full=Epidermal growth factor-like Cripto protein; AltName: Full=Cripto growth factor; Flags: Precursor [NCBI NR]
  • gi|149260447|ref|XP_001478826.1| PREDICTED: similar to cripto [Mus musculus] [NCBI NR]
  • gi|148677038|gb|EDL08985.1| teratocarcinoma-derived growth factor [Mus musculus] [NCBI NR]
  • Teratocarcinoma-derived growth factor OS=Mus musculus GN=Tdgf1 PE=1 SV=1 [Swiss-Prot]
  • (P51865) Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):9-111057896 Teratocarcinoma-derived growth factor precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • teratocarcinoma-derived growth factor [HMR_022704-rand.fasta]
  • Teratocarcinoma-derived growth factor precursor [ipi.MOUSE.v3.06.fasta]
  • Unknown (protein for MGC:97964) [Xenopus laevis]gi|6755756|ref|NP_035692.1| teratocarcinoma-derived growth factor [Mus musculus]gi|2137330|pir||I49612 teratocarcinoma-derived growth factor - mousegi|402715|gb|AAA37459.1| criptogi|1706128|sp|P51865|CRI [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Teratocarcinoma-derived growth factor precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_011562) teratocarcinoma-derived growth factor [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • teratocarcinoma-derived growth factor [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Teratocarcinoma-derived growth factor precursor (Epidermal growth factor-like Cripto protein) (Cripto growth factor) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • PREDICTED: similar to cripto [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • cripto [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=LOC100047300;Tdgf1 Teratocarcinoma-derived growth factor [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Tdgf1;LOC100047300 Teratocarcinoma-derived growth factor precursor [ipi.MOUSE_jw_12may08.contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Tdgf1 Teratocarcinoma-derived growth factor precursor [zeeyong.fasta]
  • IPI:IPI00127741.1|SWISS-PROT:P51865|TREMBL:Q3UZP8|REFSEQ:XP_001478826 Tax_Id=10090 Gene_Symbol=Tdgf1;LOC100047300 Teratocarcinoma-derived growth factor [ipi.MOUSE.fasta.20090209]
  • Tax_Id=10090 Gene_Symbol=Tdgf1;LOC100047300 Teratocarcinoma-derived growth factor [EBI-IPI_mouse_01-01-2009_reversed.fasta]
  • Teratocarcinoma-derived growth factor OS=Mus musculus GN=Tdgf1 [011711_HMR.fasta]
  • Tax_Id=10090 Gene_Symbol=Tdgf1 Teratocarcinoma-derived growth factor [EBI-IPI_mouse_2_08-18-2011_reversed.fasta]
  • sp|P51865|TDGF1_MOUSE Teratocarcinoma-derived growth factor OS=Mus musculus GN=Tdgf1 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 171 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    extracellular space [IDA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IDA]
    membrane [IEA]
    Golgi apparatus [IDA]
    extrinsic to plasma membrane [IDA]
    plasma membrane [IEA]
    anchored to membrane [IEA]
    cell surface [IDA]
    Biological Process: anterior/posterior axis specification, embryo [IMP]
    [NOT]epidermal growth factor receptor signaling pathway [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN]
    vasculogenesis [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IGI]
    gastrulation [IGI]
    anterior/posterior axis specification [IGI]
    activation of MAPK activity [UNKNOWN]
    morphogenesis of a branching structure [IDA]
    heart development [IDA]
    in utero embryonic development [IMP]
    positive regulation of cell-matrix adhesion [IMP]
    positive regulation of fibroblast proliferation [IMP]
    cell differentiation [TAS]
    regulation of cell migration [IMP]
    cardiac muscle cell differentiation [IMP]
    negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
    positive regulation of cell migration [IDA]
    Molecular Function: growth factor activity [UNKNOWN]
    protein binding [IPI]
    Wnt-protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGYFSSSVVL LVAISSAFEF GPVAGRDLAI RDNSIWDQKE PAVRDRSFQF VPSVGIQNSK  60
   61 SLNKTCCLNG GTCILGSFCA CPPSFYGRNC EHDVRKEHCG SILHGTWLPK KCSLCRCWHG 120
  121 QLHCLPQTFL PGCDGHVMDQ DLKASRTPCQ TPSVTTTFML AGACLFLDMK V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 6.522879 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ErbB-2 class receptor binding
    		•  6.03999755532215 bayes_pls_golite062009
  • growth factor activity
    		•  4.72461268561406 bayes_pls_golite062009
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.49243532917035 bayes_pls_golite062009
  • heparin binding
    		•  3.18889412817519 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.10404768355447 bayes_pls_golite062009
  • protein binding
    		•  3.02592228806142 bayes_pls_golite062009
  • binding
    		•  2.97929690141955 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.81761382193046 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.79319890241656 bayes_pls_golite062009
  • transcription factor binding
    		•  2.07092884468733 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.96338152927981 bayes_pls_golite062009
  • protein kinase activity
    		•  1.77969944626081 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.46474396447414 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.45792086043869 bayes_pls_golite062009
  • pattern binding
    		•  1.40261567769805 bayes_pls_golite062009
  • kinase activity
    		•  1.38993132583838 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36604280237149 bayes_pls_golite062009
  • glycoprotein binding
    		•  1.26303225185938 bayes_pls_golite062009
  • signal transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.21257866727 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.856364436331474 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle