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Protein Overview: KITM_MOUSE

General Information:
Name(s) found: KITM_MOUSE [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Thymidine kinase 2, mitochondrial OS=Mus musculus GN=Tk2 PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 270 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDA]
    mitochondrial inner membrane [IDA]
    Biological Process: deoxyribonucleotide metabolic process [IMP]
    DNA replication [IEA]
    mitochondrial DNA metabolic process [IMP]
    mitochondrial DNA replication [IMP]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    transferase activity [IEA]
    phosphotransferase activity, alcohol group as acceptor [IEA]
    kinase activity [IEA]
    thymidine kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLRSLRSWA ARSPRSVGPG SSGSPGSLDS GAGPLWAPRR AWPPDKDREN DKEKKAVVCI  60
   61 EGNIASGKTT CLEFFSNTTD VEVLMEPVLK WRNVHGHNPL SLMYHDASRW GLTLQTYVQL 120
  121 TMLDQHTRPQ MSPVRLMERS IYSARYIFVE NLYRGGKMPE VDYAILSEWF DWIVRNIDVS 180
  181 VDLIVYLRTT PEICYQRLKM RCREEEKVIP MEYLHAIHRL YEEWLVNGSL FPAAAPVLVI 240
  241 EADHNLEKML ELFEQNRARI LTPENWKHGP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..270] PSI-BLAST 34.221849 Deoxyribonucleoside kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.66392587433723 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  3.0424527711731 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  2.24094813695083 bayes_pls_golite062009
  • kinase activity
    		•  2.0779386406753 bayes_pls_golite062009
  • binding
    		•  2.0681607836408 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.92954258828893 bayes_pls_golite062009
  • adenylate kinase activity
    		•  1.66206135528976 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.09000822067541 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.04041661958283 bayes_pls_golite062009
  • helicase activity
    		•  1.0321619822241 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.00391607739958 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.913322399315129 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.91290128595235 bayes_pls_golite062009
  • guanylate kinase activity
    		•  0.71257393037667 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.5607032154839 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.5607032154839 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.533349084356156 bayes_pls_golite062009
  • motor activity
    		•  0.50661339105747 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • DNA binding
    		•  0.376487324624615 bayes_pls_golite062009
  • CTP synthase activity
    		•  0.318856075265301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.160605313145072 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.150159515184919 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.133736530545575 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0700789521444061 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0458386180871631 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.95561462330096E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle