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Protein Overview: FKH2_SCHPO

General Information:
Name(s) found: FKH2_SCHPO [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
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  • Fork head protein homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fkh2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Schizosaccharomyces pombe 972h-
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVRRLESKS EHISDDEERK EQLDYKKQMD VDTDRNIVLN GRLESQIAKL SVPPHEMRVV  60
   61 DDYSNSKNAE RHSGEIQAYA KFAGSTWTYY VKKIRIILGR EPANPSPKGK NEDLEVIDMN 120
  121 FGPSKVVSRK HAVVEYDLDD QTWNCSVYGR NGIKVDGKLF KNGETVKLTS GSILEVAGLQ 180
  181 MMFVLPNAAE QKQTDESTIK EDAIKSEISA AVNDAAEYGD NKKPPYSYSV MIAQAILSSS 240
  241 ECMMTLSNIY SWISTHYPYY RTTKSGWQNS IRHNLSLNKA FRKVPRKSGE QGKGMKWSIV 300
  301 PEFREEFIAK TRKTPRKRSP SSPVPLLAKK REGSPSLPIP ILPKMKDTSI PAAEPASSTT 360
  361 SARDQTPSTP KDVGSPSTAE TSAEEKQMET YKTPTHAALS DIISTHDYAL DANSASQTKK 420
  421 AAFGSPIGSS TYPTSSPAPF WKYVAVPNPH DWPQVGSYDT ISPYRNPVNS HLIYSQIQQS 480
  481 SPKKIDEQLH DLQGVDLVNG FEGISSWRES MVNKLRSSVS DSPTMNLANS NSKSSPVAVQ 540
  541 RVSTLPQASA NKQAKEMESK MSNSPTQKSK TEENNQAVRA ILDASATMEK QYDLHRLPTP 600
  601 TSQTESASVP QIANPPNSQN LVKEKSPQQY IQVPQSNVKS SA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] FFAS03 4.31 Phosphotyrosine binding domain of Rad53
    2 View Details [211..331] PSI-BLAST 41.522879 Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
    3 View Details [332..469] deduced N/A No confident structure predictions are available.
    4 View Details [470..642] MSA 9.308997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.49130250684713 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.38780975952028 bayes_pls_golite062009
  • DNA binding
    		•  3.17754626214699 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.1171915055278 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.46194647885285 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.25215920371602 bayes_pls_golite062009
  • protein binding
    		•  2.20369144716037 bayes_pls_golite062009
  • transcription factor activity
    		•  2.00503872581265 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.58636372907213 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  1.55291063824788 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.50718172248835 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45614128243985 bayes_pls_golite062009
  • R-SMAD binding
    		•  1.42136232818793 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.31247181538194 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.0211816353095 bayes_pls_golite062009
  • promoter binding
    		•  0.986206497817435 bayes_pls_golite062009
  • transcription factor binding
    		•  0.840886266060694 bayes_pls_golite062009
  • histone binding
    		•  0.719484498280197 bayes_pls_golite062009
  • chromatin binding
    		•  0.599108072971618 bayes_pls_golite062009
  • SMAD binding
    		•  0.465937265607219 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.417372097853037 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.196567610974905 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0741267027726338 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70025468248325 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.893172944075433 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.461477365615935 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.0856082199488197 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle