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Protein Overview: M3K12_MOUSE

General Information:
Name(s) found: M3K12_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|74151284|dbj|BAE38775.1| unnamed protein product [Mus musculus] [NCBI NR]
  • gi|602678|gb|AAA57280.1| DLK [NCBI NR]
  • gi|55777335|gb|AAH47158.1| Mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI NR]
  • gi|34784209|gb|AAH57572.1| Mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI NR]
  • gi|254692958|ref|NP_001157115.1| mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI NR]
  • gi|254692956|ref|NP_033608.3| mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI NR]
  • gi|17379887|sp|Q60700.1|M3K12_MOUSE RecName: Full=Mitogen-activated protein kinase kinase kinase 12; AltName: Full=Mixed lineage kinase; AltName: Full=Leucine-zipper protein kinase; Short=ZPK; AltName: Full=Dual leucine zipper bearing kinase; Short=DLK; A [NCBI NR]
  • gi|148672026|gb|EDL03973.1| mitogen activated protein kinase kinase kinase 12, isoform CRA_a [Mus musculus] [NCBI NR]
  • gi|148672024|gb|EDL03971.1| mitogen activated protein kinase kinase kinase 12, isoform CRA_a [Mus musculus] [NCBI NR]
  • gi|148672023|gb|EDL03970.1| mitogen activated protein kinase kinase kinase 12, isoform CRA_a [Mus musculus] [NCBI NR]
  • pir||A55318 serine/threonine protein kinase (EC 2.7.1.-) DLK - mouse [NCBI NR]
  • (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.1.37) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) [Swiss-Prot]
  • Mitogen-activated protein kinase kinase kinase 12 OS=Mus musculus GN=Map3k12 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):15-102957524 Mitogen-activated protein kinase kinase kinase 12 [hmr_yeast5_DM3-1_pombe.fasta]
  • Mitogen-activated protein kinase kinase kinase 12 [ipi.MOUSE.v3.06.fasta]
  • Mitogen activated protein kinase kinase kinase 12 [Mus musculus]gi|17379887|sp|Q60700|M3KC_MOUSE Mitogen-activated protein kinase kinase kinase 12 (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK)gi|1083502|pir||A55318 ser [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10090 Mitogen-activated protein kinase kinase kinase 12 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • (NM_009582) mitogen activated protein kinase kinase kinase 12; zipper (leucine) protein kinase [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Mitogen-activated protein kinase kinase kinase 12 (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mitogen activated protein kinase kinase kinase 12, isoform CRA_a [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • DLK [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Map3k12 Mitogen-activated protein kinase kinase kinase 12 [mouse-ipi-250309-contam.fasta]
  • mitogen-activated protein kinase kinase kinase 12 [Mus musculus] [NCBI-RefSeq_mouse_na_09-14-2009_con_reversed.fasta]
  • Mitogen activated protein kinase kinase kinase 12 [Mus musculus] [nr-271106-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Map3k12 Mitogen-activated protein kinase kinase kinase 12 ENSMUSG00000023050 IPI00120072 IPI00606963 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • IPI:IPI00120072.3|SWISS-PROT:Q60700|ENSEMBL:ENSMUSP00000023812|REFSEQ:NP_033608 Tax_Id=10090 Gene_Symbol=Map3k12 Mitogen-activated protein kinase kinase kinase 12 [ipi.MOUSE.fasta.20090209]
  • Mitogen-activated protein kinase kinase kinase 12 OS=Mus musculus GN=Map3k12 [011711_HMR.fasta]
  • sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus musculus GN=Map3k12 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 888 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    cytoplasm [IEA]
    membrane [IEA]
    cytosol [IDA]
    axon part [IDA]
    plasma membrane [IDA]
    Biological Process: protein amino acid autophosphorylation [IDA]
    histone phosphorylation [IDA]
    peptidyl-serine phosphorylation [IDA]
    protein amino acid phosphorylation [IDA]
    peptidyl-threonine phosphorylation [IDA]
    Molecular Function: nucleotide binding [IEA]
    magnesium ion binding [IEA]
    ATP binding [IEA]
    protein homodimerization activity [IDA]
    protein kinase activity [IEA]
    MAP kinase kinase kinase activity [IEA]
    protein serine/threonine kinase activity [IDA]
    transferase activity [IEA]
    kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG  60
   61 GGPSPSPGGE PPPEPFANSV LQLHEQDTGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
  121 LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
  181 EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
  241 VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
  301 MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
  361 HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
  421 EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
  481 LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
  541 ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 600
  601 PHEPGGLGSP GGLGVGPSAW DACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
  661 GARDPGSPPP PQGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGEGVGL LGTGREGTAG 720
  721 RGGNRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELPPSQR WPQGPNMRQS 780
  781 LSTFSSENPS DVEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDLPTSEV 840
  841 VPEREASSLP MQHQDGQGPN PEDSDCDSTE LDNSNSIDAL RPPASLPP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle