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Protein Overview: P85A_MOUSE

General Information:
Name(s) found: P85A_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|200212|gb|AAA39886.1| phosphoprotein p85 [NCBI NR]
  • gi|129388|sp|P26450.1|P85A_MOUSE RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha; AltName: Full=PI3-kinase p85 subunit alpha; AltName: Full=PtdIns-3-kinase p85-alpha; Short=PI3K [NCBI NR]
  • Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Mus musculus GN=Pik3r1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Phosphatidylinositol 3-kinase regulatory alpha subunit [hmr_yeast5_DM3-1_pombe.fasta]
  • Phosphatidylinositol 3-kinase regulatory alpha subunit (PI3-kinase p85-alpha subunit) (PtdIns-3-kinase p85-alpha) (PI3K)gi|200212|gb|AAA39886.1| phosphoprotein p85 [nrdb_11152004_Chlamydomonas]
  • Phosphatidylinositol 3-kinase regulatory alpha subunit [ipi.MOUSE.v3.06.fasta]
  • Tax_Id=10090 Phosphatidylinositol 3-kinase regulatory alpha subunit [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta]
  • Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85 subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phosphoprotein p85 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Pik3r1 Phosphatidylinositol 3-kinase regulatory subunit alpha [mouse-ipi-250309-contam.fasta]
  • Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K) [nr-271106-contam.fasta]
  • IPI:IPI00263878.1|SWISS-PROT:P26450 Tax_Id=10090 Gene_Symbol=Pik3r1 Phosphatidylinositol 3-kinase regulatory subunit alpha [ipi.MOUSE.fasta.20090209]
  • Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Mus musculus GN=Pik3r1 [011711_HMR.fasta]
    • Organism: Mus musculus
    Length: 724 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [TAS]
    soluble fraction [UNKNOWN]
    cytoplasm [IDA]
    membrane [IDA]
    cytosol [IDA]
    protein complex [UNKNOWN]
    intracellular [IEA]
    plasma membrane [UNKNOWN]
    Biological Process: response to estrogen stimulus [UNKNOWN]
    B cell differentiation [IMP]
    signal transduction [IEA]
    insulin receptor signaling pathway [UNKNOWN]
    negative regulation of cell-cell adhesion [UNKNOWN]
    insulin-like growth factor receptor signaling pathway [UNKNOWN]
    response to cAMP [UNKNOWN]
    positive regulation of myoblast differentiation [UNKNOWN]
    negative regulation of proteolysis [UNKNOWN]
    glucose metabolic process [UNKNOWN]
    positive regulation of anti-apoptosis [UNKNOWN]
    protein amino acid phosphorylation [IDA]
    response to insulin stimulus [UNKNOWN]
    negative regulation of cell-matrix adhesion [IGI]
    negative regulation of apoptosis [IDA][IGI]
    response to glucocorticoid stimulus [UNKNOWN]
    negative regulation of osteoclast differentiation [IGI]
    positive regulation of cell migration [UNKNOWN][IGI]
    Molecular Function: protein kinase binding [UNKNOWN]
    protein domain specific binding [UNKNOWN]
    phosphoinositide 3-kinase regulator activity [IEA]
    protein binding [IPI]
    protein C-terminus binding [UNKNOWN]
    insulin receptor substrate binding [UNKNOWN][IPI]
    phosphoprotein binding [UNKNOWN]
    kinase activity [IEA]
    receptor binding [UNKNOWN]
    1-phosphatidylinositol-3-kinase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGPEARP EDIGWLNGYN  60
   61 ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 120
  121 QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 180
  181 VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 240
  241 QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 300
  301 RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 360
  361 STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 420
  421 DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 480
  481 RTAIEAFNET IKIFEEQCQT QERYSKEYIG KFKREGNEKE IQRIMHNHDK LKSRISEIID 540
  541 SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 600
  601 ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 660
  661 VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA 720
  721 QQRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle