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Protein Overview: UBE2E2

General Information:
Name(s) found: UBE2E2 [HGNC (HUGO)]
Description(s) found:
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  • gi|47606201|sp|Q96LR5.1|UB2E2_HUMAN RecName: Full=Ubiquitin-conjugating enzyme E2 E2; AltName: Full=Ubiquitin-protein ligase E2; AltName: Full=Ubiquitin carrier protein E2; AltName: Full=UbcH8 [NCBI NR]
  • gi|22749327|ref|NP_689866.1| ubiquitin-conjugating enzyme E2E 2 [Homo sapiens] [NCBI NR]
  • gi|18490187|gb|AAH22332.1| Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [Homo sapiens] [NCBI NR]
  • gi|16553859|dbj|BAB71605.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119584728|gb|EAW64324.1| ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119584725|gb|EAW64321.1| ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI NR]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [HGNC (HUGO)]
  • (Q96LR5) Ubiquitin-conjugating enzyme E2 E2 (EC 6.3.2.19) (Ubiquitin-protein ligase E2) (Ubiquitin carrier protein E2) (UbcH8) [Swiss-Prot]
  • Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens GN=UBE2E2 PE=1 SV=1 [Swiss-Prot]
  • Hypothetical protein FLJ25157 [hmr_yeast5_DM3-1_pombe.fasta]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5) [071204_hmrz_cont.fasta]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [Homo sapiens]gi|18490187|gb|AAH22332.1| Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [Homo sapiens]gi|16553859|dbj|BAB71605.1| unnamed protein product [Homo sapiens]gi|47606201|s [nrdb_11152004_Chlamydomonas]
  • Ubiquitin-conjugating enzyme E2 E2 (Ubiquitin-protein ligase E2) (Ubiquitin carrier protein E2) (UbcH8) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Ubiquitin-conjugating enzyme E2 E2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5) [Homo sapiens] [HumanGallus06162005.fasta]
  • hypothetical protein FLJ25157 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 UBIQUITIN-CONJUGATING ENZYME E2 E2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Ubiquitin-conjugating enzyme E2 E2; AltName: Full=Ubiquitin-protein ligase E2; AltName: Full=Ubiquitin carrier protein E2; AltName: Full=UbcH8 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=UBE2E2 Ubiquitin-conjugating enzyme E2 E2 [human-ipi-250309-contam.fasta]
  • ubiquitin-conjugating enzyme E2E 2 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00102173.3|SWISS-PROT:Q96LR5|ENSEMBL:ENSP00000379931;ENSP00000389769;ENSP00000401053|REFSEQ:NP_689866|H-INV:HIT000014493|VEGA:OTTHUMP00000161048;OTTHUMP00000170456;OTTHUMP00000170458;OTTHUMP00000208342 Tax_Id=9606 Gene_Symbol=UBE2E2 Ubiquitin-conju [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=UBE2E2 Ubiquitin-conjugating enzyme E2 E2 ENSG00000182247 IPI00102173 IPI00021346 IPI00377011 IPI00795732 IPI00797418 IPI00798086 [drosphohumanreversed.fasta]
  • ubiquitin-conjugating enzyme E2 E2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q96LR5; RecName: Full=Ubiquitin-conjugating enzyme E2 E2; AltName: Full=Ubiquitin-protein ligase E2; AltName: Full=Ubiquitin carrier protein E2; AltName: Full=UbcH8; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens GN=UBE2E2 [011711_HMR.fasta]
  • IPI:IPI00102173.3|SWISS-PROT:Q96LR5|ENSEMBL:ENSP00000379931;ENSP00000389769;ENSP00000401053|REFSEQ:NP_689866|H-INV:HIT000014493|VEGA:OTTHUMP00000161048;OTTHUMP00000170456;OTTHUMP00000170458;OTTHUMP00000208342 Tax_Id=9606 Gene_Symbol=UBE2E2 Ubiquitin-conjugating enzyme E2 E2 [ipi.HUMAN.fasta.20100406]
  • Ubiquitin-conjugating enzyme E2 E2 n=12 Tax=Tetrapoda RepID=UB2E2_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=UBE2E2 Synonyms=FLJ25157|UBCH8 ubiquitin-conjugating enzyme E2 E2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00102173.3|SWISS-PROT:Q96LR5|ENSEMBL:ENSP00000379931;ENSP00000401053|REFSEQ:NP_689866|H-INV:HIT000014493|VEGA:OTTHUMP00000161048;OTTHUMP00000208342 Tax_Id=9606 Gene_Symbol=UBE2E2 Ubiquitin-conjugating enzyme E2 E2 [ipi.HUMAN.20110912.fasta]
  • Ubiquitin-conjugating enzyme E2 E2 GN=UBE2E2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast), isoform CRA_a OS=Homo sapiens GN=UBE2E2 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 201 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEAQRVDD SPSTSGGSSD GDQRESVQQE PEREQVQPKK KEGKISSKTA AKLSTSAKRI  60
   61 QKELAEITLD PPPNCSAGPK GDNIYEWRST ILGPPGSVYE GGVFFLDITF SPDYPFKPPK 120
  121 VTFRTRIYHC NINSQGVICL DILKDNWSPA LTISKVLLSI CSLLTDCNPA DPLVGSIATQ 180
  181 YMTNRAEHDR MARQWTKRYA T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] PSI-BLAST 51.522879 Human ubiquitin conjugating enzyme E2E2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • ligase activity
    		•  5.17219147802758 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • HLH domain binding
    		•  2.41376652679018 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle