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Protein Overview: SLC6A4

General Information:
Name(s) found: SLC6A4 [HGNC (HUGO)]
Description(s) found:
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  • gi|58700442|gb|AAW80933.1| serotonin transporter [Homo sapiens] [NCBI NR]
  • pir||A47398 serotonin transporter - human [NCBI NR]
  • gi|47481194|gb|AAH69484.1| Solute carrier family 6 member 4 [Homo sapiens] [NCBI NR]
  • gi|4507043|ref|NP_001036.1| solute carrier family 6 member 4 [Homo sapiens] [NCBI NR]
  • gi|400630|sp|P31645.1|SC6A4_HUMAN RecName: Full=Sodium-dependent serotonin transporter; AltName: Full=5HT transporter; Short=5HTT; AltName: Full=Solute carrier family 6 member 4 [NCBI NR]
  • gi|36433|emb|CAA50029.1| serotonin transporter [Homo sapiens] [NCBI NR]
  • gi|300444|gb|AAB26687.1| serotonin transporter, serotonin uptake site, 5-HT uptake site [human, platelets, Peptide, 630 aa] [NCBI NR]
  • gi|291820|gb|AAA35492.1| Na+/Cl- dependent serotonin transporter [NCBI NR]
  • gi|157057087|gb|ABV02581.1| solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [Homo sapiens] [NCBI NR]
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [HGNC (HUGO)]
  • Sodium-dependent serotonin transporter OS=Homo sapiens GN=SLC6A4 PE=1 SV=1 [Swiss-Prot]
  • (P31645) Sodium-dependent serotonin transporter (5HT transporter) (5HTT) [Swiss-Prot]
  • Sodium-dependent serotonin transporter [hmr_yeast5_DM3-1_pombe.fasta]
  • solute carrier family 6 member 4; 5-hydroxytryptamine transporter; 5HT transporter; sodium-dependent serotonin transporter; Na+/Cl- dependent serotonin transporter [HMR_022704.fasta]
  • solute carrier family 6 member 4 [Homo sapiens]gi|47481194|gb|AAH69484.1| Solute carrier family 6 member 4 [Homo sapiens]gi|300444|gb|AAB26687.1| serotonin transporter, serotonin uptake site, 5-HT uptake site [human, platelets, Peptide, 630 aa]gi|36433 [nrdb_11152004_Chlamydomonas]
  • Sodium-dependent serotonin transporter (5HT transporter) (5HTT) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Sodium-dependent serotonin transporter [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001045) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 (neurotransmitter transporter, serotonin), [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • solute carrier family 6 member 4 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • solute carrier family 6 member 4; 5-hydroxytryptamine transporter; 5HT transporter; sodium-dependent serotonin transporter; Na+/Cl- dependent serotonin transporter [Homo sapiens] [HumanGallus06162005.fasta]
  • serotonin transporter, serotonin uptake site, 5-HT uptake site [human, platelets, Peptide, 630 aa] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Solute carrier family 6 member 4 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • serotonin transporter [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Na+/Cl- dependent serotonin transporter [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SODIUM-DEPENDENT SEROTONIN TRANSPORTER [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Sodium-dependent serotonin transporter; AltName: Full=5HT transporter; Short=5HTT [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC6A4 Sodium-dependent serotonin transporter [human-ipi-250309-contam.fasta]
  • IPI:IPI00790986.2|SWISS-PROT:P31645|TREMBL:B3VRQ0;B3VRQ5;B3VRR0;B3VRR5;B3VRS0;B3VRS5;B3VRU0;B3VRU5;B3VRV0;B3VRV5;B3VRW0;Q5EE02;Q9NYN7|ENSEMBL:ENSP00000261707;ENSP00000385822|REFSEQ:NP_001036|H-INV:HIT000191681|VEGA:OTTHUMP00000163633 Tax_Id=9606 Gene_Symb [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • P31645; RecName: Full=Sodium-dependent serotonin transporter; AltName: Full=5HT transporter; AltName: Full=Solute carrier family 6 member 4; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Sodium-dependent serotonin transporter OS=Homo sapiens GN=SLC6A4 [011711_HMR.fasta]
  • IPI:IPI00790986.2|SWISS-PROT:P31645|TREMBL:B3VRQ0;B3VRQ5;B3VRR0;B3VRR5;B3VRS0;B3VRS5;B3VRU0;B3VRU5;B3VRV0;B3VRV5;B3VRW0;Q5EE02;Q9NYN7|ENSEMBL:ENSP00000261707;ENSP00000385822|REFSEQ:NP_001036|H-INV:HIT000191681|VEGA:OTTHUMP00000163633 Tax_Id=9606 Gene_Symbol=SLC6A4 Sodium-dependent serotonin transporter [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=SLC6A4 Synonyms=5-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|hSERT sodium-dependent serotonin transporter [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Sodium-dependent serotonin transporter GN=SLC6A4 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 630 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR  60
   61 HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 120
  121 YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM 180
  181 AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH 240
  241 RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 300
  301 TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 360
  361 ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 420
  421 TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT 480
  481 LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC 540
  541 WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 600
  601 PGTFKERIIK SITPETPTEI PCGDIRLNAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..630] PSI-BLAST 78.09691 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycine transmembrane transporter activity
    		•  11.3462233177624 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  7.22946100807286 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.81299720354921 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  6.70367174546308 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  6.56670564439223 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  6.33167860290665 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  5.71289406236765 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  5.69783123069145 bayes_pls_golite062009
  • transporter activity
    		•  5.41729552690402 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  5.3581057816165 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.33581060534257 bayes_pls_golite062009
  • monoamine transmembrane transporter activity
    		•  5.31806171557443 bayes_pls_golite062009
  • serotonin transmembrane transporter activity
    		•  5.22437090102976 bayes_pls_golite062009
  • norepinephrine transmembrane transporter activity
    		•  5.09475702546654 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  4.68541050294042 bayes_pls_golite062009
  • taurine transmembrane transporter activity
    		•  4.61676680068455 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  4.6018168706595 bayes_pls_golite062009
  • taurine:sodium symporter activity
    		•  4.44443197285659 bayes_pls_golite062009
  • neurotransmitter transporter activity
    		•  4.39219594760011 bayes_pls_golite062009
  • taurine binding
    		•  4.32148954519383 bayes_pls_golite062009
  • beta-alanine transmembrane transporter activity
    		•  4.32148954519383 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  3.87108500507564 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  3.84070781430742 bayes_pls_golite062009
  • cation:amino acid symporter activity
    		•  3.743834410703 bayes_pls_golite062009
  • L-amino acid transmembrane transporter activity
    		•  3.59581534621744 bayes_pls_golite062009
  • gamma-aminobutyric acid:sodium symporter activity
    		•  3.54502199515084 bayes_pls_golite062009
  • L-gamma-aminobutyric acid transmembrane transporter activity
    		•  3.54502199515084 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  3.52796002058936 bayes_pls_golite062009
  • organic acid:sodium symporter activity
    		•  3.13700347625317 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  3.06163068745863 bayes_pls_golite062009
  • symporter activity
    		•  3.06163068745863 bayes_pls_golite062009
  • D-amino acid transmembrane transporter activity
    		•  3.05547330089228 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.96397568544208 bayes_pls_golite062009
  • sodium ion transmembrane transporter activity
    		•  2.96263002501356 bayes_pls_golite062009
  • neurotransmitter:sodium symporter activity
    		•  2.85886896504752 bayes_pls_golite062009
  • solute:sodium symporter activity
    		•  2.69043348576901 bayes_pls_golite062009
  • dopamine transmembrane transporter activity
    		•  2.58457054403528 bayes_pls_golite062009
  • dopamine:sodium symporter activity
    		•  2.58457054403528 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.25031429733377 bayes_pls_golite062009
  • sodium:amino acid symporter activity
    		•  2.11262345327121 bayes_pls_golite062009
  • binding
    		•  2.09841803960057 bayes_pls_golite062009
  • cation channel activity
    		•  1.98082939418842 bayes_pls_golite062009
  • amine binding
    		•  1.94062923967142 bayes_pls_golite062009
  • ion channel activity
    		•  1.46844692044197 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.43924755059525 bayes_pls_golite062009
  • signal transducer activity
    		•  1.43924755059525 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.43469451491638 bayes_pls_golite062009
  • channel activity
    		•  1.43469451491638 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.42613760305472 bayes_pls_golite062009
  • cocaine binding
    		•  1.19517364220938 bayes_pls_golite062009
  • receptor activity
    		•  0.933085226787869 bayes_pls_golite062009
  • potassium:amino acid symporter activity
    		•  0.9050760910728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.849801862133405 bayes_pls_golite062009
  • protein binding
    		•  0.541360409289497 bayes_pls_golite062009
  • norephinephrine:sodium symporter activity
    		•  0.331385084269681 bayes_pls_golite062009
  • neurotransmitter binding
    		•  0.276720775023801 bayes_pls_golite062009
  • protein complex binding
    		•  0.131316764331102 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle