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Protein Overview: ATP2A1

General Information:
Name(s) found: ATP2A1 [HGNC (HUGO)]
Description(s) found:
Found 26 descriptions.
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  • ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1001 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL  60
   61 LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 120
  121 EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 180
  181 TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 240
  241 ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 300
  301 ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
  361 MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 420
  421 NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 480
  481 KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 540
  541 VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 600
  601 DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 660
  661 LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 720
  721 GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 780
  781 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 840
  841 GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 900
  901 LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 960
  961 ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1001] PSI-BLAST 1000.0 Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • sodium:potassium-exchanging ATPase activity
    		•  11.4867387451974 bayes_pls_golite062009
  • nucleotide-sugar transmembrane transporter activity
    		•  7.73647015205787 bayes_pls_golite062009
  • sodium ion binding
    		•  7.21987278426553 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  6.61812979618651 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.16458999629467 bayes_pls_golite062009
  • lutropin-choriogonadotropic hormone receptor binding
    		•  6.14594591865745 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  6.13700166730075 bayes_pls_golite062009
  • copper-exporting ATPase activity
    		•  6.06195961901175 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  5.47065318246954 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  5.16712079031129 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.12847433447136 bayes_pls_golite062009
  • calcium ion transmembrane transporter activity
    		•  4.89423417418827 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.89102962531082 bayes_pls_golite062009
  • calcium-transporting ATPase activity
    		•  4.71666652104511 bayes_pls_golite062009
  • S100 alpha binding
    		•  4.64026825799847 bayes_pls_golite062009
  • manganese ion transmembrane transporter activity
    		•  4.59844049598217 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.52111403634053 bayes_pls_golite062009
  • manganese-transporting ATPase activity
    		•  4.45375275315101 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.43965512012576 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.4041848950244 bayes_pls_golite062009
  • potassium ion binding
    		•  4.29725564052466 bayes_pls_golite062009
  • alkali metal ion binding
    		•  4.29725564052466 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.06187878627466 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  3.84972831650983 bayes_pls_golite062009
  • hydrogen:potassium-exchanging ATPase activity
    		•  3.75155313777252 bayes_pls_golite062009
  • potassium ion transmembrane transporter activity
    		•  3.67159922549869 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  3.64319424996894 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  3.61939073485494 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  3.61617223449215 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  3.61611109366015 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  3.59950478178662 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  3.59648410376424 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  3.59597574155277 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  3.50756527505825 bayes_pls_golite062009
  • potassium-transporting ATPase activity
    		•  3.05226511256937 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.94399396510177 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.67481820167988 bayes_pls_golite062009
  • ATPase activity
    		•  2.6484149118374 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.59976165242012 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.58022495603077 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.57794784093209 bayes_pls_golite062009
  • transporter activity
    		•  2.4278971299555 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  2.32222259910497 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.3001871224946 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.23918161210694 bayes_pls_golite062009
  • binding
    		•  1.87920689058615 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65471354901537 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.56757380990645 bayes_pls_golite062009
  • signal transducer activity
    		•  1.56757380990645 bayes_pls_golite062009
  • DNA binding
    		•  1.54753536588285 bayes_pls_golite062009
  • protein binding
    		•  1.43342050279888 bayes_pls_golite062009
  • hydrolase activity
    		•  1.41787493642465 bayes_pls_golite062009
  • calcium ion binding
    		•  0.955088860346801 bayes_pls_golite062009
  • catalytic activity
    		•  0.672845620038718 bayes_pls_golite062009
  • cation binding
    		•  0.437836127635358 bayes_pls_golite062009
  • metal ion binding
    		•  0.437836127635358 bayes_pls_golite062009
  • ion binding
    		•  0.432214651300696 bayes_pls_golite062009
  • protein transporter activity
    		•  0.13404659324695 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0837108257865773 bayes_pls_golite062009
  • ATP binding
    		•  0.0679996061631102 bayes_pls_golite062009
  • 4-nitrophenylphosphatase activity
    		•  0.0565932349160398 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0333631569718018 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.0190459429277992 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle