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View Structure Prediction Details

Protein: ATP2A1
Organism: Homo sapiens
Length: 1001 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATP2A1.

Description E-value Query
Range		 Subject
Range
AT2A3_CHICK - Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 OS=Gallus gallus GN=ATP2A3 PE=2 SV=1
 0.0 [1..1000] [1..1000]
gi|31873280 - gi|31873280|emb|CAD97631.1| hypothetical protein [Homo sapiens]
 0.0 [1..992] [61..1052]
gi|73853826, gi|... - gi|73853826|ref|NP_001027498.1| hypothetical protein LOC613090 [Xenopus (Silurana) tropicalis], gi|6...
 0.0 [1..992] [1..992]
AT2A1_RAT - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Rattus norvegicus GN=Atp2a1 PE=1 SV=1
 0.0 [1..992] [1..992]
AT2A1_MOUSE - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Mus musculus GN=Atp2a1 PE=1 SV=1
 0.0 [1..992] [1..992]
AT2A1_RABIT - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 OS=Oryctolagus cuniculus GN=ATP2A1 PE=1 SV=1
 0.0 [1..1001] [1..1001]
gi|54648603, gi|... - gi|54648603|gb|AAH84962.1| LOC495440 protein [Xenopus laevis], gi|147900253|ref|NP_001088563.1| hypo...
 0.0 [1..1001] [1..1001]
gi|12055495 - gi|12055495|emb|CAC20903.1| Ca2+-ATPase [Rana sylvatica]
 0.0 [1..992] [1..992]
gi|41055728, gi|... - gi|41055728|ref|NP_957259.1| ATPase, Ca++ transporting, slow twitch 2 [Danio rerio], gi|28277523|gb|...
 0.0 [1..992] [1..990]

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Predicted Domain #1
Region A:
Residues: [1-1001] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL  60
   61 LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 120
  121 EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL 180
  181 TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA 240
  241 ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 300
  301 ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 360
  361 MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC 420
  421 NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK 480
  481 KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 540
  541 VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML 600
  601 DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD 660
  661 LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 720
  721 GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 780
  781 LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 840
  841 GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA 900
  901 LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 960
  961 ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEDPEDERR K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1iwoA
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sodium:potassium-exchanging ATPase activity 11.4867387451974 bayes_pls_golite062009
nucleotide-sugar transmembrane transporter activity 7.73647015205787 bayes_pls_golite062009
sodium ion binding 7.21987278426553 bayes_pls_golite062009
copper ion transmembrane transporter activity 6.61812979618651 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.16458999629467 bayes_pls_golite062009
lutropin-choriogonadotropic hormone receptor binding 6.14594591865745 bayes_pls_golite062009
copper-transporting ATPase activity 6.13700166730075 bayes_pls_golite062009
copper-exporting ATPase activity 6.06195961901175 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 5.47065318246954 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 5.16712079031129 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 5.12847433447136 bayes_pls_golite062009
calcium ion transmembrane transporter activity 4.89423417418827 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 4.89102962531082 bayes_pls_golite062009
calcium-transporting ATPase activity 4.71666652104511 bayes_pls_golite062009
S100 alpha binding 4.64026825799847 bayes_pls_golite062009
manganese ion transmembrane transporter activity 4.59844049598217 bayes_pls_golite062009
cation transmembrane transporter activity 4.52111403634053 bayes_pls_golite062009
manganese-transporting ATPase activity 4.45375275315101 bayes_pls_golite062009
ion transmembrane transporter activity 4.43965512012576 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 4.4041848950244 bayes_pls_golite062009
potassium ion binding 4.29725564052466 bayes_pls_golite062009
alkali metal ion binding 4.29725564052466 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.06187878627466 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 3.84972831650983 bayes_pls_golite062009
hydrogen:potassium-exchanging ATPase activity 3.75155313777252 bayes_pls_golite062009
potassium ion transmembrane transporter activity 3.67159922549869 bayes_pls_golite062009
cation-transporting ATPase activity 3.64319424996894 bayes_pls_golite062009
primary active transmembrane transporter activity 3.61939073485494 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 3.61617223449215 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.61611109366015 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 3.59950478178662 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 3.59648410376424 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 3.59597574155277 bayes_pls_golite062009
active transmembrane transporter activity 3.50756527505825 bayes_pls_golite062009
potassium-transporting ATPase activity 3.05226511256937 bayes_pls_golite062009
ATPase activity, coupled 2.94399396510177 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.67481820167988 bayes_pls_golite062009
ATPase activity 2.6484149118374 bayes_pls_golite062009
pyrophosphatase activity 2.59976165242012 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.58022495603077 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.57794784093209 bayes_pls_golite062009
transporter activity 2.4278971299555 bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism 2.32222259910497 bayes_pls_golite062009
transmembrane transporter activity 2.3001871224946 bayes_pls_golite062009
substrate-specific transporter activity 2.23918161210694 bayes_pls_golite062009
binding 1.87920689058615 bayes_pls_golite062009
nucleic acid binding 1.65471354901537 bayes_pls_golite062009
molecular transducer activity 1.56757380990645 bayes_pls_golite062009
signal transducer activity 1.56757380990645 bayes_pls_golite062009
DNA binding 1.54753536588285 bayes_pls_golite062009
protein binding 1.43342050279888 bayes_pls_golite062009
hydrolase activity 1.41787493642465 bayes_pls_golite062009
calcium ion binding 0.955088860346801 bayes_pls_golite062009
catalytic activity 0.672845620038718 bayes_pls_golite062009
cation binding 0.437836127635358 bayes_pls_golite062009
metal ion binding 0.437836127635358 bayes_pls_golite062009
ion binding 0.432214651300696 bayes_pls_golite062009
protein transporter activity 0.13404659324695 bayes_pls_golite062009
structure-specific DNA binding 0.0837108257865773 bayes_pls_golite062009
ATP binding 0.0679996061631102 bayes_pls_golite062009
4-nitrophenylphosphatase activity 0.0565932349160398 bayes_pls_golite062009
adenyl ribonucleotide binding 0.0333631569718018 bayes_pls_golite062009
adenyl nucleotide binding 0.0190459429277992 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle