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Protein Overview: GINS4

General Information:
Name(s) found: GINS4 [HGNC (HUGO)]
Description(s) found:
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  • gi|74732928|sp|Q9BRT9.1|SLD5_HUMAN RecName: Full=DNA replication complex GINS protein SLD5; AltName: Full=GINS complex subunit 4 [NCBI NR]
  • gi|193787826|dbj|BAG53029.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|189066625|dbj|BAG36172.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|157835879|pdb|2Q9Q|F Chain F, The Crystal Structure Of Full Length Human Gins Complex [NCBI NR]
  • gi|157835875|pdb|2Q9Q|B Chain B, The Crystal Structure Of Full Length Human Gins Complex [NCBI NR]
  • gi|146387472|pdb|2E9X|H Chain H, The Crystal Structure Of Human Gins Core Complex [NCBI NR]
  • gi|146387468|pdb|2E9X|D Chain D, The Crystal Structure Of Human Gins Core Complex [NCBI NR]
  • gi|14150122|ref|NP_115712.1| GINS complex subunit 4 [Homo sapiens] [NCBI NR]
  • gi|13543689|gb|AAH05995.1| GINS complex subunit 4 (Sld5 homolog) [Homo sapiens] [NCBI NR]
  • gi|119583661|gb|EAW63257.1| SLD5 homolog, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119583660|gb|EAW63256.1| SLD5 homolog, isoform CRA_a [Homo sapiens] [NCBI NR]
  • GINS complex subunit 4 (Sld5 homolog) [HGNC (HUGO)]
  • DNA replication complex GINS protein SLD5 OS=Homo sapiens GN=GINS4 PE=1 SV=1 [Swiss-Prot]
  • Similar to RIKEN cDNA 4933405K01 gene [hmr_yeast5_DM3-1_pombe.fasta]
  • hypothetical protein MGC14799 [HMR_022704.fasta]
  • SLD5 [071204_hmrz_cont.fasta]
  • SLD5 [Homo sapiens]gi|13543689|gb|AAH05995.1| SLD5 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 SLD5 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_032336) hypothetical protein MGC14799 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • SLD5 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • hypothetical protein MGC14799 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Chain F, The Crystal Structure Of Full Length Human Gins Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, The Crystal Structure Of Full Length Human Gins Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain H, The Crystal Structure Of Human Gins Core Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain D, The Crystal Structure Of Human Gins Core Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SLD5 homolog, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • GINS complex subunit 4 (Sld5 homolog) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 GINS complex subunit 4 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • GINS complex subunit 4 [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=GINS4 Isoform 1 of DNA replication complex GINS protein SLD5 [human-ipi-250309-contam.fasta]
  • IPI:IPI00031614.2|SWISS-PROT:Q9BRT9-1|TREMBL:B2R8H5|ENSEMBL:ENSP00000276533|REFSEQ:NP_115712|H-INV:HIT000293274|VEGA:OTTHUMP00000177424;OTTHUMP00000177425 Tax_Id=9606 Gene_Symbol=GINS4 Isoform 1 of DNA replication complex GINS protein SLD5 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=GINS4 GINS complex subunit 4 ENSG00000147536 IPI00031614 IPI00792990 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=GINS4 GINS complex subunit 4 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • DNA replication complex GINS protein SLD5 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9BRT9;B2R8H5;Q8N648; RecName: Full=DNA replication complex GINS protein SLD5; AltName: Full=GINS complex subunit 4; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of DNA replication complex GINS protein SLD5 OS=Homo sapiens GN=GINS4 [011711_HMR.fasta]
  • IPI:IPI00031614.2|SWISS-PROT:Q9BRT9-1|TREMBL:D3DSY0|ENSEMBL:ENSP00000276533|REFSEQ:NP_115712|H-INV:HIT000293274|VEGA:OTTHUMP00000177424;OTTHUMP00000177425 Tax_Id=9606 Gene_Symbol=GINS4 Isoform 1 of DNA replication complex GINS protein SLD5 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=GINS4 Synonyms=MGC14799|SLD5 DNA replication complex GINS protein SLD5 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00031614.2|SWISS-PROT:Q9BRT9-1|ENSEMBL:ENSP00000276533;ENSP00000428754|REFSEQ:NP_115712|H-INV:HIT000293274|VEGA:OTTHUMP00000225812 Tax_Id=9606 Gene_Symbol=GINS4 Isoform 1 of DNA replication complex GINS protein SLD5 [ipi.HUMAN.20110912.fasta]
  • DNA replication complex GINS protein SLD5 GN=GINS4 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 223 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEEVDFLGQ DSDGGSEEVV LTPAELIERL EQAWMNEKFA PELLESKPEI VECVMEQLEH  60
   61 MEENLRRAKR EDLKVSIHQM EMERIRYVLS SYLRCRLMKI EKFFPHVLEK EKTRPEGEPS 120
  121 SLSPEELAFA REFMANTESY LKNVALKHMP PNLQKVDLFR AVPKPDLDSY VFLRVRERQE 180
  181 NILVEPDTDE QRDYVIDLEK GSQHLIRYKT IAPLVASGAV QLI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. GINS4 gi|112491310 gi|13786858 gi|150261449 gi|219109210, gi...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..223] PSI-BLAST 79.69897 No description for 2e9xD was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3'-5' DNA helicase activity
    		•  3.30007058745861 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.7662250039458 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • protein binding
    		•  1.52285169518311 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.2336233528067 bayes_pls_golite062009
  • helicase activity
    		•  1.2110072302388 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.406116199163083 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.350000641617868 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.33576520693158 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.333445385039412 bayes_pls_golite062009
  • catalytic activity
    		•  0.161911144249814 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle