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Protein Overview: STK24

General Information:
Name(s) found: STK24 [HGNC (HUGO)]
Description(s) found:
Found 36 descriptions.
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  • serine/threonine kinase 24 (STE20 homolog, yeast) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSRAQLWGL ALNKRRATLP HPGGSTNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK  60
   61 VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL 120
  121 DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ 180
  181 LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELARGEPP HSELHPMKVL 240
  241 FLIPKNNPPT LEGNYSKPLK EFVEACLNKE PSFRPTAKEL LKHKFILRNA KKTSYLTELI 300
  301 DRYKRWKAEQ SHDDSSSEDS DAETDGQASG GSDSGDWIFT IREKDPKNLE NGALQPSDLD 360
  361 RNKMKDIPKR PFSQCLSTII SPLFAELKEK SQACGGNLGS IEELRGAIYL AEEACPGISD 420
  421 TMVAQLVQRL QRYSLSGGGT SSH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..305] PSI-BLAST 58.045757 Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
    2 View Details [306..443] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.22172815474021 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655396214040669 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.631882811427766 bayes_pls_golite062009
  • DNA binding
    		•  0.599969415455862 bayes_pls_golite062009
  • tubulin binding
    		•  0.525721160726465 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transcription factor activity
    		•  0.457173041568166 bayes_pls_golite062009
  • actin binding
    		•  0.456340967230669 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • microtubule binding
    		•  0.191960933574742 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle