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Protein Overview: OGG1

General Information:
Name(s) found: OGG1 [HGNC (HUGO)]
Description(s) found:
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  • gi|5305498|gb|AAD41680.1|AF088282_1 8-hydroxyguanine-specific DNA glycosylase type 1a [Homo sapiens] [NCBI NR]
  • gi|4505495|ref|NP_002533.1| 8-oxoguanine DNA-glycosylase 1 isoform 1a [Homo sapiens] [NCBI NR]
  • gi|2351704|gb|AAB68614.1| 8-hydroxyguanine glycosylase/lyase [Homo sapiens] [NCBI NR]
  • gi|2197083|gb|AAB61340.1| 8-oxoguanine DNA glycosylase 1 [Homo sapiens] [NCBI NR]
  • gi|21668118|gb|AAM74236.1|AF521807_1 8-oxoguanine DNA glycosylase [Homo sapiens] [NCBI NR]
  • gi|1906757|dbj|BAA19103.1| hOGG1 [Homo sapiens] [NCBI NR]
  • gi|1903206|emb|CAA72536.1| 8-oxoguanine DNA glycosylase homolog 1 [Homo sapiens] [NCBI NR]
  • gi|1890182|emb|CAA72414.1| DNA glycosylase/AP lyase [Homo sapiens] [NCBI NR]
  • gi|18158657|pdb|1KO9|A Chain A, Native Structure Of The Human 8-Oxoguanine Dna Glycosylase Hogg1 [NCBI NR]
  • gi|12643548|sp|O15527.2|OGG1_HUMAN RecName: Full=N-glycosylase/DNA lyase; Includes: RecName: Full=8-oxoguanine DNA glycosylase; Includes: RecName: Full=DNA-(apurinic or apyrimidinic site) lyase; Short=AP lyase [NCBI NR]
  • gi|119584387|gb|EAW63983.1| 8-oxoguanine DNA glycosylase, isoform CRA_f [Homo sapiens] [NCBI NR]
  • 8-oxoguanine DNA glycosylase [HGNC (HUGO)]
  • N-glycosylase/DNA lyase OS=Homo sapiens GN=OGG1 PE=1 SV=2 [Swiss-Prot]
  • Splice isoform 1A of O15527 [hmr_yeast5_DM3-1_pombe.fasta]
  • 8-oxoguanine DNA glycosylase isoform 1a; 8-hydroxyguanine DNA glycosylase [HMR_022704.fasta]
  • 8-oxoguanine DNA glycosylase isoform 1a [Homo sapiens]gi|2197083|gb|AAB61340.1| 8-oxoguanine DNA glycosylase 1 [Homo sapiens]gi|21668118|gb|AAM74236.1| 8-oxoguanine DNA glycosylase [Homo sapiens]gi|1903206|emb|CAA72536.1| 8-oxoguanine DNA glycosylase h [nrdb_11152004_Chlamydomonas]
  • N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase ; DNA-(apurinic or apyrimidinic site) lyase (AP lyase)] [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1A of N-glycosylase/DNA lyase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_002542) 8-oxoguanine DNA glycosylase isoform 1a; 8-hydroxyguanine DNA glycosylase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase isoform 1a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase isoform 1a; 8-hydroxyguanine DNA glycosylase [Homo sapiens] [HumanGallus06162005.fasta]
  • Chain A, Native Structure Of The Human 8-Oxoguanine Dna Glycosylase Hogg1 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hOGG1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase, isoform CRA_f [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DNA glycosylase/AP lyase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-hydroxyguanine-specific DNA glycosylase type 1a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-oxoguanine DNA glycosylase homolog 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 8-hydroxyguanine glycosylase/lyase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1A of N-glycosylase/DNA lyase [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF N-GLYCOSYLASE/DNA LYASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=OGG1 Isoform 1A of N-glycosylase/DNA lyase [human-ipi-250309-contam.fasta]
  • 8-oxoguanine DNA-glycosylase 1 isoform 1a [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00007312.1|SWISS-PROT:O15527-1|ENSEMBL:ENSP00000342851|REFSEQ:NP_002533|VEGA:OTTHUMP00000122619;OTTHUMP00000170118 Tax_Id=9606 Gene_Symbol=OGG1 Isoform 1A of N-glycosylase/DNA lyase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • N-glycosylase/DNA lyase isoform 1a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O15527;A8K1E3;O00390;O00670;O00705;O14876;O95488;P78554;Q9BW42;Q9UIK0;Q9UIK1;Q9UIK2;Q9UL34;Q9Y2C0;Q9Y2C1;Q9Y6C3;Q9Y6C4; RecName: Full=N-glycosylase/DNA lyase; Includes: RecName: Full=8-oxoguanine DNA glycosylase; Includes: RecName: Full=DNA-(apurinic or apyrimidinic site) lyase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1A of N-glycosylase/DNA lyase OS=Homo sapiens GN=OGG1 [011711_HMR.fasta]
  • GeneSymbol=OGG1 Synonyms=HMMH|HOGG1|MUTM|OGH1 N-glycosylase/DNA lyase isoform 1a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00007312.1|SWISS-PROT:O15527-1|TREMBL:E5KPN1;E5KPS3|ENSEMBL:ENSP00000342851|REFSEQ:NP_002533|VEGA:OTTHUMP00000122619 Tax_Id=9606 Gene_Symbol=OGG1 Isoform 1A of N-glycosylase/DNA lyase [ipi.HUMAN.20110912.fasta]
  • N-glycosylase/DNA lyase GN=OGG1 [Doctor+uniprot-HUMAN-120911.fasta]
  • 8-oxoguanine DNA glycosylase, isoform CRA_f OS=Homo sapiens GN=OGG1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA  60
   61 DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF 120
  121 QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 180
  181 FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL 240
  241 CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG 300
  301 NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..345] PSI-BLAST 94.045757 8-oxoguanine glycosylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.8124964619976 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.26870112679392 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.62178291472984 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86205700023542 bayes_pls_golite062009
  • DNA binding
    		•  2.5120791469793 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39934080314995 bayes_pls_golite062009
  • hydrolase activity
    		•  2.39042189031819 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.18053745735048 bayes_pls_golite062009
  • binding
    		•  2.13602784299456 bayes_pls_golite062009
  • catalytic activity
    		•  2.13345932727422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.08009333103564 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.00388798014411 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  1.2016453685638 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91701565472544 bayes_pls_golite062009
  • transcription factor binding
    		•  0.88531282989512 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.85419760398899 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • protein binding
    		•  0.663243680565331 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.57099109384393 bayes_pls_golite062009
  • RNA polymerase III transcription factor activity
    		•  0.365027701616215 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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