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Protein Overview: TRPC4

General Information:
Name(s) found: TRPC4 [HGNC (HUGO)]
Description(s) found:
Found 37 descriptions.
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  • transient receptor potential cation channel, subfamily C, member 4 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 977 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEAEIYFK  60
   61 ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL LHAIRKEVVG AVELLLNHKK 120
  121 PSGEKQVPPI LLDKQFSEFT PDITPIILAA HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE 180
  181 CVSSSDVDSL RHSRSRLNIY KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE 240
  241 YEELSRQCKQ FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF 300
  301 VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA PKSPLGLFIR 360
  361 KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT IVEWMILPWV LGFIWGEIKQ 420
  421 MWDGGLQDYI HDWWNLMDFV MNSLYLATIS LKIVAFVKYS ALNPRESWDM WHPTLVAEAL 480
  481 FAIANIFSSL RLISLFTANS HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY 540
  541 YEETKGLTCK GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTEFVGATM 600
  601 FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG GTLPTPFNVI 660
  661 PSPKSLWYLI KWIWTHLCKK KMRRKPESFG TIGRRAADNL RRHHQYQEVM RNLVKRYVAA 720
  721 MIRDAKTEEG LTEENFKELK QDISSFRFEV LGLLRGSKLS TIQSANASKE SSNSADSDEK 780
  781 SDSEGNSKDK KKNFSLFDLT TLIHPRSAAI ASERHNISNG SALVVQEPPR EKQRKVNFVT 840
  841 DIKNFGLFHR RSKQNAAEQN ANQIFSVSEE VARQQAAGPL ERNIQLESRG LASRGDLSIP 900
  901 GLSEQCVLVD HRERNTDTLG LQVGKRVCPF KSEKVVVEDT VPIIPKEKHA KEEDSSIDYD 960
  961 LNLPDTVTHE DYVTTRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] PSI-BLAST 17.39794 No description for 2fo1E was found.
    2 View Details [286..357] deduced N/A No confident structure predictions are available.
    3 View Details [358..692] PSI-BLAST 23.154902 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [693..761] deduced N/A No confident structure predictions are available.
    5 View Details [762..977] PSI-BLAST 5.30103 Crystal structure of human ADP-ribose pyrophosphatase NUDT9

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  3.14284918783319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.77672397171221 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.76658625373154 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.55165879409032 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.23934826890513 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.23707606020328 bayes_pls_golite062009
  • cation channel activity
    		•  2.02327029328545 bayes_pls_golite062009
  • manganese ion transmembrane transporter activity
    		•  2.01178023504656 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.73151832826112 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.60956352556846 bayes_pls_golite062009
  • ion channel activity
    		•  1.49956611721119 bayes_pls_golite062009
  • channel activity
    		•  1.45389648555252 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.45389648555252 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.44857305885791 bayes_pls_golite062009
  • hydrolase activity
    		•  1.36927203866255 bayes_pls_golite062009
  • transporter activity
    		•  1.26144641115218 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.19048684580333 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.06120201707805 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.842503783075326 bayes_pls_golite062009
  • calcium channel activity
    		•  0.795261805936657 bayes_pls_golite062009
  • binding
    		•  0.770007304343682 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.549441354164187 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.333193584681061 bayes_pls_golite062009
  • protein binding
    		•  0.0150710541177431 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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