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Protein Overview: FEN1

General Information:
Name(s) found: FEN1 [HGNC (HUGO)]
Description(s) found:
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  • gi|729475|sp|P39748.1|FEN1_HUMAN RecName: Full=Flap endonuclease 1; Short=FEN-1; AltName: Full=Flap structure-specific endonuclease 1; AltName: Full=Maturation factor 1; Short=MF1; Short=hFEN-1; AltName: Full=DNase IV [NCBI NR]
  • gi|704377|gb|AAB32522.1| DNase IV=nuclear 42 kda 5' -> 3' exonuclease [human, HeLa cells, Peptide, 380 aa] [NCBI NR]
  • gi|642090|gb|AAA91331.1| endonuclease [NCBI NR]
  • gi|54695918|gb|AAV38331.1| flap structure-specific endonuclease 1 [Homo sapiens] [NCBI NR]
  • gi|49168608|emb|CAG38799.1| FEN1 [Homo sapiens] [NCBI NR]
  • gi|4758356|ref|NP_004102.1| flap structure-specific endonuclease 1 [Homo sapiens] [NCBI NR]
  • gi|3980293|emb|CAA54166.1| flap endonuclease-1 [Homo sapiens] [NCBI NR]
  • gi|3169155|gb|AAC23394.1| FEN1_HUMAN; MATURATION FACTOR 1 (MF1); DNase IV; RAD2_HUMAN [Homo sapiens] [NCBI NR]
  • gi|21668123|gb|AAM74238.1|AF523117_1 flap structure-specific endonuclease 1 [Homo sapiens] [NCBI NR]
  • gi|189053461|dbj|BAG35627.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • pir||A56531 DNA structure-specific endonuclease FEN1 [validated] - human [NCBI NR]
  • gi|12653113|gb|AAH00323.1| Flap structure-specific endonuclease 1 [Homo sapiens] [NCBI NR]
  • gi|119594378|gb|EAW73972.1| flap structure-specific endonuclease 1 [Homo sapiens] [NCBI NR]
  • flap structure-specific endonuclease 1 [HGNC (HUGO)]
  • Flap endonuclease 1 OS=Homo sapiens GN=FEN1 PE=1 SV=1 [Swiss-Prot]
  • Flap endonuclease-1 [hmr_yeast5_DM3-1_pombe.fasta]
  • flap structure-specific endonuclease 1; maturation factor-1; DNase IV [HMR_022704.fasta]
  • flap structure-specific endonuclease 1 [Homo sapiens]gi|4758356|ref|NP_004102.1| flap structure-specific endonuclease 1 [Homo sapiens]gi|21668123|gb|AAM74238.1| flap structure-specific endonuclease 1 [Homo sapiens]gi|12653113|gb|AAH00323.1| Flap struct [nrdb_11152004_Chlamydomonas]
  • Flap endonuclease-1 (Maturation factor 1) (MF1) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Flap endonuclease 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_004111) flap structure-specific endonuclease 1; maturation factor-1; DNase IV [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • flap structure-specific endonuclease 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Flap endonuclease-1 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • flap structure-specific endonuclease 1; maturation factor-1; DNase IV [Homo sapiens] [HumanGallus06162005.fasta]
  • Flap endonuclease 1 (FEN-1) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DNase IV=nuclear 42 kda 5' -> 3' exonuclease [human, HeLa cells, Peptide, 380 aa] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Flap structure-specific endonuclease 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • flap endonuclease-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FEN1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • FEN1_HUMAN; MATURATION FACTOR 1 (MF1); DNase IV; RAD2_HUMAN [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • endonuclease [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 FLAP ENDONUCLEASE-1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=FEN1 Flap endonuclease 1 [human-ipi-250309-contam.fasta]
  • Flap endonuclease 1 (Flap structure-specific endonuclease 1) (FEN-1) (Maturation factor 1) (MF1) (hFEN-1) (DNase IV) [nr-271106-contam.fasta]
  • IPI:IPI00026215.1|SWISS-PROT:P39748|TREMBL:B4DWZ4;Q6FHX6|ENSEMBL:ENSP00000305480|REFSEQ:NP_004102|H-INV:HIT000029517 Tax_Id=9606 Gene_Symbol=FEN1 Flap endonuclease 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=FEN1 Flap endonuclease 1 ENSG00000168496 IPI00026215 [drosphohumanreversed.fasta]
  • flap endonuclease 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P39748; RecName: Full=Flap endonuclease 1; AltName: Full=Flap structure-specific endonuclease 1; AltName: Full=Maturation factor 1; AltName: Full=DNase IV; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Flap endonuclease 1 OS=Homo sapiens GN=FEN1 [011711_HMR.fasta]
  • GeneSymbol=FEN1 Synonyms=FEN-1|MF1|RAD2 flap endonuclease 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00026215.1|SWISS-PROT:P39748|TREMBL:B4DWZ4;Q6FHX6|ENSEMBL:ENSP00000305480|REFSEQ:NP_004102|H-INV:HIT000029517|VEGA:OTTHUMP00000238148 Tax_Id=9606 Gene_Symbol=FEN1 Flap endonuclease 1 [ipi.HUMAN.20110912.fasta]
  • Flap endonuclease 1 GN=FEN1 [Doctor+uniprot-HUMAN-120911.fasta]
  • Flap endonuclease 1 OS=Homo sapiens GN=FEN1 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 380 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIQGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET  60
   61 TSHLMGMFYR TIRMMENGIK PVYVFDGKPP QLKSGELAKR SERRAEAEKQ LQQAQAAGAE 120
  121 QEVEKFTKRL VKVTKQHNDE CKHLLSLMGI PYLDAPSEAE ASCAALVKAG KVYAAATEDM 180
  181 DCLTFGSPVL MRHLTASEAK KLPIQEFHLS RILQELGLNQ EQFVDLCILL GSDYCESIRG 240
  241 IGPKRAVDLI QKHKSIEEIV RRLDPNKYPV PENWLHKEAH QLFLEPEVLD PESVELKWSE 300
  301 PNEEELIKFM CGEKQFSEER IRSGVKRLSK SRQGSTQGRL DDFFKVTGSL SSAKRKEPEP 360
  361 KGSTKKKAKT GAAGKFKRGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..380] PSI-BLAST 112.0 Crystal structure of the human FEN1-PCNA complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  5.44893156272125 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  4.17543266498933 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.1412804577877 bayes_pls_golite062009
  • flap endonuclease activity
    		•  4.10438637013244 bayes_pls_golite062009
  • exonuclease activity
    		•  3.99717729574528 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  3.90367500308359 bayes_pls_golite062009
  • endonuclease activity
    		•  3.40075034200919 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  3.19536858640519 bayes_pls_golite062009
  • nuclease activity
    		•  2.9643999717473 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.76402807313057 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  2.49388502336873 bayes_pls_golite062009
  • hydrolase activity
    		•  2.4418166499042 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.33034300966639 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  2.26658239783943 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.10834170214137 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  2.09057967200253 bayes_pls_golite062009
  • binding
    		•  2.06833406478856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02510018436829 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • DNA binding
    		•  1.93844174573408 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.81850767854435 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.70042864382698 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • ribonuclease H activity
    		•  1.29762010718359 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  1.15948049342759 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.901965019685213 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.626785110524684 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.512509234493511 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.50487165366129 bayes_pls_golite062009
  • protein binding
    		•  0.488846604207788 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.351084053450465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.319622686426271 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.312346277055223 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.14861832363159 bayes_pls_golite062009
  • 3'-5'-exodeoxyribonuclease activity
    		•  0.0205129272358 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle