YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SPARC

General Information:
Name(s) found: SPARC [HGNC (HUGO)]
Description(s) found:
SHOW ONLY BEST
  • gi|48145715|emb|CAG33080.1| SPARC [Homo sapiens] [NCBI NR]
  • gi|47938229|gb|AAH72457.1| Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens] [NCBI NR]
  • pir||GEHUN osteonectin precursor [validated] - human [NCBI NR]
  • gi|4507171|ref|NP_003109.1| secreted protein, acidic, cysteine-rich [Homo sapiens] [NCBI NR]
  • gi|338313|gb|AAA60570.1| osteonectin [Homo sapiens] [NCBI NR]
  • gi|29462|emb|CAA68724.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|14124970|gb|AAH08011.1| Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens] [NCBI NR]
  • gi|13436389|gb|AAH04974.1| Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens] [NCBI NR]
  • gi|129283|sp|P09486.1|SPRC_HUMAN RecName: Full=SPARC; AltName: Full=Secreted protein acidic and rich in cysteine; AltName: Full=Osteonectin; Short=ON; AltName: Full=Basement-membrane protein 40; Short=BM-40; Flags: Precursor [NCBI NR]
  • gi|119582076|gb|EAW61672.1| secreted protein, acidic, cysteine-rich (osteonectin), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119582074|gb|EAW61670.1| secreted protein, acidic, cysteine-rich (osteonectin), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119582073|gb|EAW61669.1| secreted protein, acidic, cysteine-rich (osteonectin), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119582072|gb|EAW61668.1| secreted protein, acidic, cysteine-rich (osteonectin), isoform CRA_b [Homo sapiens] [NCBI NR]
  • secreted protein, acidic, cysteine-rich (osteonectin) [HGNC (HUGO)]
  • SPARC OS=Homo sapiens GN=SPARC PE=1 SV=1 [Swiss-Prot]
  • SPARC precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • secreted protein, acidic, cysteine-rich (osteonectin); Osteonectin (secreted protein, acidic, cysteine-rich) [HMR_022704.fasta]
  • secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens]gi|47938229|gb|AAH72457.1| Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens]gi|14124970|gb|AAH08011.1| Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sap [nrdb_11152004_Chlamydomonas]
  • SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 SPARC precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003118) secreted protein, acidic, cysteine-rich (osteonectin); Osteonectin (secreted protein, acidic, cysteine-rich) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • secreted protein, acidic, cysteine-rich (osteonectin); Osteonectin (secreted protein, acidic, cysteine-rich) [Homo sapiens] [HumanGallus06162005.fasta]
  • secreted protein, acidic, cysteine-rich [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • secreted protein, acidic, cysteine-rich (osteonectin), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Secreted protein, acidic, cysteine-rich (osteonectin) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SPARC [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • osteonectin [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SPARC PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SPARC SPARC [human-ipi-250309-contam.fasta]
  • secreted protein, acidic, cysteine-rich precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00014572.1|SWISS-PROT:P09486|TREMBL:B2RDL6;B4DRV4;Q6IBK4;Q6QE20|ENSEMBL:ENSP00000231061|REFSEQ:NP_003109|H-INV:HIT000264901|VEGA:OTTHUMP00000160617 Tax_Id=9606 Gene_Symbol=SPARC SPARC [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SPARC SPARC precursor ENSG00000113140 IPI00014572 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SPARC SPARC precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • SPARC precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P09486;Q6IBK4; RecName: Full=SPARC; AltName: Full=Secreted protein acidic and rich in cysteine; AltName: Full=Osteonectin; AltName: Full=Basement-membrane protein 40; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • GeneSymbol=SPARC Synonyms=ON SPARC precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • SPARC GN=SPARC [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 303 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE  60
   61 ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK VCSNDNKTFD 120
  121 SSCHFFATKC TLEGTKKGHK LHLDYIGPCK YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE 180
  181 RDEDNNLLTE KQKLRVKKIH ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ 240
  241 HPIDGYLSHT ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD 300
  301 LVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] MSA 1.06399 View MSA. No confident structure predictions are available.
    2 View Details [62..303] PSI-BLAST 89.69897 C-terminal (EC) domain of BM-40/SPARC/osteonectin; Domain of BM-40/SPARC/osteonectin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • receptor binding
    		•  4.60755835611133 bayes_pls_golite062009
  • growth factor activity
    		•  3.99369234248402 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  3.33042410578504 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.86713236325679 bayes_pls_golite062009
  • heparin binding
    		•  2.49012176521764 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  2.05269657997842 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.03157496298046 bayes_pls_golite062009
  • binding
    		•  1.9180887037845 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  1.53810598398471 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.36634831540772 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.32276701662595 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.29357847772022 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • serine-type endopeptidase inhibitor activity
    		•  1.23661226950215 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.17748426017837 bayes_pls_golite062009
  • transcription factor binding
    		•  1.12166879177902 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.99108904558314 bayes_pls_golite062009
  • protein binding
    		•  0.583752463668114 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.37583220367244 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  0.22929572509808 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.204626400011227 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.14454341648094 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0981928858355918 bayes_pls_golite062009
  • DNA binding
    		•  0.0960817636106102 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle