Protein Overview: SIRT1

General Information:
Name(s) found:	SIRT1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|82399173\|gb\|ABB72675.1\| sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|7657575\|ref\|NP_036370.2\| sirtuin 1 isoform a [Homo sapiens] [NCBI NR] gi\|7555471\|gb\|AAD40849.2\|AF083106_1 sirtuin type 1 [Homo sapiens] [NCBI NR] gi\|55957429\|emb\|CAI16036.1\| sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) [Homo sapiens] [NCBI NR] gi\|38258633\|sp\|Q96EB6.2\|SIRT1_HUMAN RecName: Full=NAD-dependent deacetylase sirtuin-1; Short=hSIRT1; AltName: Full=SIR2-like protein 1; Short=hSIR2 [NCBI NR] gi\|119574644\|gb\|EAW54259.1\| sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI NR] gi\|119574643\|gb\|EAW54258.1\| sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI NR] gi\|11596121\|gb\|AAG38486.1\|AF235040_1 SIR2alpha protein [Homo sapiens] [NCBI NR] sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) [HGNC (HUGO)] NAD-dependent deacetylase sirtuin-1 OS=Homo sapiens GN=SIRT1 PE=1 SV=2 [Swiss-Prot] NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens GN=SIRT1 PE=1 SV=2 [Swiss-Prot] Sirtuin type 1 [hmr_yeast5_DM3-1_pombe.fasta] sirtuin 1; sir2-like 1; sirtuin type 1; SIR2alpha; sirtuin silent mating type information regulation 2 homolog 1 (S. cerevisiae) [HMR_022704.fasta] sirtuin 1; sir2-like 1; SIR2alpha; sirtuin silent mating type information regulation 2 homolog 1 (S. cerevisiae); sirtuin type 1; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1 [071204_hmrz_cont.fasta] sirtuin 1 [Homo sapiens]gi\|7555471\|gb\|AAD40849.2\| sirtuin type 1 [Homo sapiens]gi\|38258633\|sp\|Q96EB6\|SIR1_HUMAN NAD-dependent deacetylase sirtuin 1 (hSIRT1) (hSIR2) (SIR2-like protein 1)gi\|11596121\|gb\|AAG38486.1\| SIR2alpha protein [Homo sapiens] [nrdb_11152004_Chlamydomonas] NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) [Yateslab_human_na_07-28-2006_reversed.fasta] Tax_Id=9606 NAD-dependent deacetylase sirtuin-1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_012238) sirtuin 1; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; sirtuin type 1; sir2-like 1; SIR2alpha [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] sirtuin 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Tax_Id=9606 NAD-dependent deacetylase sirtuin 1 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta] sirtuin 1; sir2-like 1; SIR2alpha; sirtuin silent mating type information regulation 2 homolog 1 (S. cerevisiae); sirtuin type 1; sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1 [Homo sapiens] [HumanGallus06162005.fasta] sirtuin 1; sir2-like 1; sirtuin type 1; SIR2alpha; sirtuin silent mating type information regulation 2 homolog 1 (S. cerevisiae) [Homo sapiens] [human-NCBI-042104-rand.fasta] NAD-dependent deacetylase sirtuin-1 (hSIRT1) (SIR2-like protein 1) (hSIR2) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] SIR2alpha protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] sirtuin type 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 NAD-DEPENDENT DEACETYLASE SIRTUIN 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=NAD-dependent deacetylase sirtuin-1; Short=hSIRT1; AltName: Full=SIR2-like protein 1; Short=hSIR2 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] sirtuin 1 isoform a [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=SIRT1 NAD-dependent deacetylase sirtuin-1 [human-ipi-250309-contam.fasta] IPI:IPI00016802.1\|SWISS-PROT:Q96EB6\|ENSEMBL:ENSP00000212015\|REFSEQ:NP_036370\|H-INV:HIT000066539\|VEGA:OTTHUMP00000019691 Tax_Id=9606 Gene_Symbol=SIRT1 NAD-dependent deacetylase sirtuin-1 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=SIRT1 NAD-dependent deacetylase sirtuin-1 ENSG00000096717 IPI00016802 [drosphohumanreversed.fasta] NAD-dependent deacetylase sirtuin-1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Q96EB6;Q2XNF6;Q5JVQ0;Q9GZR9;Q9Y6F0; RecName: Full=NAD-dependent deacetylase sirtuin-1; AltName: Full=SIR2-like protein 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] NAD-dependent deacetylase sirtuin-1 OS=Homo sapiens GN=SIRT1 [011711_HMR.fasta] GeneSymbol=SIRT1 Synonyms=SIR2L1 NAD-dependent deacetylase sirtuin-1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00016802.1\|SWISS-PROT:Q96EB6\|TREMBL:A8K128\|ENSEMBL:ENSP00000212015\|REFSEQ:NP_036370\|H-INV:HIT000066539\|VEGA:OTTHUMP00000019691 Tax_Id=9606 Gene_Symbol=SIRT1 NAD-dependent deacetylase sirtuin-1 [ipi.HUMAN.20110912.fasta] NAD-dependent protein deacetylase sirtuin-1 GN=SIRT1 [Doctor+uniprot-HUMAN-120911.fasta] Sirtuin (Silent mating type information regulation 2 homolog) 1 (S. cerevisiae), isoform CRA_a OS=Homo sapiens GN=SIRT1 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
Organism:	Homo sapiens
Length:	747 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV  60
   61 PAAARGCPGA AAAALWREAE AEAAAAGGEQ EAQATAAAGE GDNGPGLQGP SREPPLADNL 120
  121 YDEDDDDEGE EEEEAAAAAI GYRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP 180
  181 RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPELDDMTL WQIVINILSE PPKRKKRKDI 240
  241 NTIEDAVKLL QECKKIIVLT GAGVSVSCGI PDFRSRDGIY ARLAVDFPDL PDPQAMFDIE 300
  301 YFRKDPRPFF KFAKEIYPGQ FQPSLCHKFI ALSDKEGKLL RNYTQNIDTL EQVAGIQRII 360
  361 QCHGSFATAS CLICKYKVDC EAVRGDIFNQ VVPRCPRCPA DEPLAIMKPE IVFFGENLPE 420
  421 QFHRAMKYDK DEVDLLIVIG SSLKVRPVAL IPSSIPHEVP QILINREPLP HLHFDVELLG 480
  481 DCDVIINELC HRLGGEYAKL CCNPVKLSEI TEKPPRTQKE LAYLSELPPT PLHVSEDSSS 540
  541 PERTSPPDSS VIVTLLDQAA KSNDDLDVSE SKGCMEEKPQ EVQTSRNVES IAEQMENPDL 600
  601 KNVGSSTGEK NERTSVAGTV RKCWPNRVAK EQISRRLDGN QYLFLPPNRY IFHGAEVYSD 660
  661 SEDDVLSSSS CGSNSDSGTC QSPSLEEPME DESEIEEFYN GLEDEPDVPE RAGGAGFGTD 720
  721 GDDQEAINEA ISVKQEVTDM NYPSNKS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..214]	MSA	2.13697	View MSA. No confident structure predictions are available.
2	View Details	[215..543]	PSI-BLAST	77.69897	Sirt2 histone deacetylase
3	View Details	[544..747]	MSA	1.147941	View MSA. No confident structure predictions are available.

Protein Overview: SIRT1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: