| Protein: | SIRT1 |
| Organism: | Homo sapiens |
| Length: | 747 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIRT1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..747] | [1..741] |
|
|
0.0 | [1..747] | [1..737] |
|
|
0.0 | [1..747] | [1..745] |
|
|
0.0 | [1..747] | [1..734] |
|
|
0.0 | [88..747] | [139..796] |
|
|
0.0 | [193..747] | [1..555] |
|
|
0.0 | [1..746] | [1..755] |
|
Region A: Residues: [1-214] |
1 11 21 31 41 51
| | | | | |
1 MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV 60
61 PAAARGCPGA AAAALWREAE AEAAAAGGEQ EAQATAAAGE GDNGPGLQGP SREPPLADNL 120
121 YDEDDDDEGE EEEEAAAAAI GYRDNLLFGD EIITNGFHSC ESDEEDRASH ASSSDWTPRP 180
181 RIGPYTFVQQ HLMIGTDPRT ILKDLLPETI PPPE
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [215-543] |
1 11 21 31 41 51
| | | | | |
1 LDDMTLWQIV INILSEPPKR KKRKDINTIE DAVKLLQECK KIIVLTGAGV SVSCGIPDFR 60
61 SRDGIYARLA VDFPDLPDPQ AMFDIEYFRK DPRPFFKFAK EIYPGQFQPS LCHKFIALSD 120
121 KEGKLLRNYT QNIDTLEQVA GIQRIIQCHG SFATASCLIC KYKVDCEAVR GDIFNQVVPR 180
181 CPRCPADEPL AIMKPEIVFF GENLPEQFHR AMKYDKDEVD LLIVIGSSLK VRPVALIPSS 240
241 IPHEVPQILI NREPLPHLHF DVELLGDCDV IINELCHRLG GEYAKLCCNP VKLSEITEKP 300
301 PRTQKELAYL SELPPTPLHV SEDSSSPER
|
| Detection Method: | |
| Confidence: | 77.69897 |
| Match: | 1j8fA |
| Description: | Sirt2 histone deacetylase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein deacetylase activity | 9.15022242957651 | bayes_pls_golite062009 |
| histone deacetylase activity | 9.04876491350231 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| NAD-dependent protein deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| deacetylase activity | 8.11496387956068 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 5.83127897351395 | bayes_pls_golite062009 |
| tubulin deacetylase activity | 4.98963898611597 | bayes_pls_golite062009 |
| NAD+ ADP-ribosyltransferase activity | 4.62921662347995 | bayes_pls_golite062009 |
| transcription regulator activity | 2.9155913558118 | bayes_pls_golite062009 |
| DNA binding | 2.43141001866996 | bayes_pls_golite062009 |
| nucleic acid binding | 2.41433477472968 | bayes_pls_golite062009 |
| transcription repressor activity | 2.24657784428979 | bayes_pls_golite062009 |
| deoxyhypusine synthase activity | 2.1085255199596 | bayes_pls_golite062009 |
| binding | 2.06552694538163 | bayes_pls_golite062009 |
| transporter activity | 1.76261412171597 | bayes_pls_golite062009 |
| histone binding | 1.71445510915336 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K9 specific) | 1.68797257022964 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.64212790017753 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.63570644537317 | bayes_pls_golite062009 |
| protein binding | 1.52593340148652 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | 1.52525209607051 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.32048615966057 | bayes_pls_golite062009 |
| transcription factor activity | 1.30143289828088 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 1.23228262988951 | bayes_pls_golite062009 |
| transcription factor binding | 1.14766678956419 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 1.12563314760659 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 1.05455660689212 | bayes_pls_golite062009 |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity | 0.963519974868694 | bayes_pls_golite062009 |
| inorganic cation transmembrane transporter activity | 0.80255051678392 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | 0.787415791033691 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | 0.787415791033691 | bayes_pls_golite062009 |
| catalytic activity | 0.739210399081789 | bayes_pls_golite062009 |
| hydrolase activity | 0.569270681616522 | bayes_pls_golite062009 |
| monovalent inorganic cation transmembrane transporter activity | 0.56841955336063 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.54005617175343 | bayes_pls_golite062009 |
| hydrogen ion transmembrane transporter activity | 0.48607021854476 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K14 specific) | 0.311143037505781 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 0.114062221123972 | bayes_pls_golite062009 |
| nucleosome binding | 0.0697729459540009 | bayes_pls_golite062009 |
|
Region A: Residues: [544-747] |
1 11 21 31 41 51
| | | | | |
1 TSPPDSSVIV TLLDQAAKSN DDLDVSESKG CMEEKPQEVQ TSRNVESIAE QMENPDLKNV 60
61 GSSTGEKNER TSVAGTVRKC WPNRVAKEQI SRRLDGNQYL FLPPNRYIFH GAEVYSDSED 120
121 DVLSSSSCGS NSDSGTCQSP SLEEPMEDES EIEEFYNGLE DEPDVPERAG GAGFGTDGDD 180
181 QEAINEAISV KQEVTDMNYP SNKS
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
