YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: TFPI

General Information:
Name(s) found: TFPI [HGNC (HUGO)]
Description(s) found:
SHOW ONLY BEST
  • pir||TIHUGK tissue factor pathway inhibitor precursor [validated] - human [NCBI NR]
  • gi|62822258|gb|AAY14807.1| unknown [Homo sapiens] [NCBI NR]
  • gi|5454114|ref|NP_006278.1| tissue factor pathway inhibitor isoform a precursor [Homo sapiens] [NCBI NR]
  • gi|29725893|gb|AAO89075.1| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Homo sapiens] [NCBI NR]
  • gi|187206|gb|AAA59526.1| lipoprotein-associated coagulation inhibitor [Homo sapiens] [NCBI NR]
  • gi|186829|gb|AAA59480.1| lipoprotein associated coagulation inhibitor [Homo sapiens] [NCBI NR]
  • gi|180546|gb|AAA52022.1| lipoprotein-associated coagulation inhibitor precursor [Homo sapiens] [NCBI NR]
  • gi|125932|sp|P10646.1|TFPI1_HUMAN RecName: Full=Tissue factor pathway inhibitor; Short=TFPI; AltName: Full=Lipoprotein-associated coagulation inhibitor; Short=LACI; AltName: Full=Extrinsic pathway inhibitor; Short=EPI; Flags: Precursor [NCBI NR]
  • gi|119631327|gb|EAX10922.1| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119631326|gb|EAX10921.1| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), isoform CRA_a [Homo sapiens] [NCBI NR]
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [HGNC (HUGO)]
  • (P10646) Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein-associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI) [Swiss-Prot]
  • Tissue factor pathway inhibitor OS=Homo sapiens GN=TFPI PE=1 SV=1 [Swiss-Prot]
  • Splice isoform Alpha of P10646 [hmr_yeast5_DM3-1_pombe.fasta]
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Homo sapiens]gi|5454114|ref|NP_006278.1| tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Homo sapiens]gi|68690|pir||TIHUGK tissue factor path [nrdb_11152004_Chlamydomonas]
  • Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein-associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Alpha of Tissue factor pathway inhibitor precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006287) tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • tissue factor pathway inhibitor isoform a precursor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [Homo sapiens] [HumanGallus06162005.fasta]
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) isoform a [Homo sapiens] [human-contam-plus-rand.fasta]
  • tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unknown [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • lipoprotein associated coagulation inhibitor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • lipoprotein-associated coagulation inhibitor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • lipoprotein-associated coagulation inhibitor precursor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform Alpha of Tissue factor pathway inhibitor precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF TISSUE FACTOR PATHWAY INHIBITOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TFPI Isoform Alpha of Tissue factor pathway inhibitor [human-ipi-250309-contam.fasta]
  • IPI:IPI00021834.1|SWISS-PROT:P10646-1|TREMBL:B2R8Y9;Q53TS4|ENSEMBL:ENSP00000233156;ENSP00000376172|REFSEQ:NP_006278|H-INV:HIT000305404|VEGA:OTTHUMP00000163472 Tax_Id=9606 Gene_Symbol=TFPI Isoform Alpha of Tissue factor pathway inhibitor [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=TFPI Isoform Alpha of Tissue factor pathway inhibitor precursor ENSG00000003436 IPI00021834 IPI00218184 IPI00555718 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TFPI Isoform Alpha of Tissue factor pathway inhibitor precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P10646;O95103; RecName: Full=Tissue factor pathway inhibitor; AltName: Full=Lipoprotein-associated coagulation inhibitor; AltName: Full=Extrinsic pathway inhibitor; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform Alpha of Tissue factor pathway inhibitor OS=Homo sapiens GN=TFPI [011711_HMR.fasta]
  • GeneSymbol=TFPI Synonyms=EPI|LACI|TFI|TFPI1 tissue factor pathway inhibitor isoform a precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00021834.1|SWISS-PROT:P10646-1|TREMBL:B2R8Y9|ENSEMBL:ENSP00000233156;ENSP00000376172|REFSEQ:NP_006278|H-INV:HIT000305404|VEGA:OTTHUMP00000163472 Tax_Id=9606 Gene_Symbol=TFPI Isoform Alpha of Tissue factor pathway inhibitor [ipi.HUMAN.20110912.fasta]
  • Tissue factor pathway inhibitor GN=TFPI [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD  60
   61 GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 120
  121 KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 180
  181 GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG 240
  241 KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF 300
  301 VKNM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] PSI-BLAST 24.522879 X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
    2 View Details [194..304] PSI-BLAST 10.30103 Tissue factor pathway inhibitor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • immunoglobulin binding
    		•  2.37115313923133 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  2.16573290057234 bayes_pls_golite062009
  • binding
    		•  1.64118506628038 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.5217535137938 bayes_pls_golite062009
  • serine-type endopeptidase inhibitor activity
    		•  1.20182235233856 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.818151972033617 bayes_pls_golite062009
  • protein complex binding
    		•  0.74868021629849 bayes_pls_golite062009
  • protein binding
    		•  0.592299740533878 bayes_pls_golite062009
    2
    Term Confidence Notes
  • immunoglobulin binding
    		•  2.37115313923133 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  2.16573290057234 bayes_pls_golite062009
  • binding
    		•  1.64118506628038 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.5217535137938 bayes_pls_golite062009
  • serine-type endopeptidase inhibitor activity
    		•  1.20182235233856 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.818151972033617 bayes_pls_golite062009
  • protein complex binding
    		•  0.74868021629849 bayes_pls_golite062009
  • protein binding
    		•  0.592299740533878 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle