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View Structure Prediction Details

Protein: TFPI
Organism: Homo sapiens
Length: 304 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFPI.

Description E-value Query
Range		 Subject
Range
TFPI1_MACMU - Tissue factor pathway inhibitor OS=Macaca mulatta GN=TFPI PE=2 SV=1
 4.0E-65 [1..304] [1..304]
gi|114582123, gi... - gi|114582123|ref|XP_001162140.1| PREDICTED: tissue factor pathway inhibitor isoform 10 [Pan troglody...
 5.0E-63 [1..304] [1..304]
gi|55725390 - gi|55725390|emb|CAH89559.1| hypothetical protein [Pongo abelii]
gi|197099492 - gi|197099492|ref|NP_001124681.1| tissue factor pathway inhibitor (lipoprotein-associated coagulation...
 6.0E-63 [1..304] [1..304]
TFPI1_RABIT - Tissue factor pathway inhibitor OS=Oryctolagus cuniculus GN=TFPI PE=2 SV=2
 2.0E-61 [5..303] [1..299]
TFPI1_RAT - Tissue factor pathway inhibitor OS=Rattus norvegicus GN=Tfpi PE=2 SV=1
 1.0E-55 [6..299] [6..301]

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Predicted Domain #1
Region A:
Residues: [1-193] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD  60
   61 GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 120
  121 KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 180
  181 GFQVDNYGTQ LNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.522879
Match: 1bikA
Description: X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
immunoglobulin binding 2.37115313923133 bayes_pls_golite062009
peptidase inhibitor activity 2.16573290057234 bayes_pls_golite062009
binding 1.64118506628038 bayes_pls_golite062009
endopeptidase inhibitor activity 1.5217535137938 bayes_pls_golite062009
serine-type endopeptidase inhibitor activity 1.20182235233856 bayes_pls_golite062009
enzyme inhibitor activity 0.818151972033617 bayes_pls_golite062009
protein complex binding 0.74868021629849 bayes_pls_golite062009
protein binding 0.592299740533878 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [194-304] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNNSLTPQST KVPSLFEFHG PSWCLTPADR GLCRANENRF YYNSVIGKCR PFKYSGCGGN  60
   61 ENNFTSKQEC LRACKKGFIQ RISKGGLIKT KRKRKKQRVK IAYEEIFVKN M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 1irhA
Description: Tissue factor pathway inhibitor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
immunoglobulin binding 2.37115313923133 bayes_pls_golite062009
peptidase inhibitor activity 2.16573290057234 bayes_pls_golite062009
binding 1.64118506628038 bayes_pls_golite062009
endopeptidase inhibitor activity 1.5217535137938 bayes_pls_golite062009
serine-type endopeptidase inhibitor activity 1.20182235233856 bayes_pls_golite062009
enzyme inhibitor activity 0.818151972033617 bayes_pls_golite062009
protein complex binding 0.74868021629849 bayes_pls_golite062009
protein binding 0.592299740533878 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle