Protein Overview: TFPI

General Information:
Name(s) found:	TFPI [HGNC (HUGO)]
Description(s) found: Found 38 descriptions. SHOW ALL	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	304 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM HSFCAFKADD  60
   61 GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC KKMCTRDNAN RIIKTTLQQE 120
  121 KPDFCFLEED PGICRGYITR YFYNNQTKQC ERFKYGGCLG NMNNFETLEE CKNICEDGPN 180
  181 GFQVDNYGTQ LNAVNNSLTP QSTKVPSLFE FHGPSWCLTP ADRGLCRANE NRFYYNSVIG 240
  241 KCRPFKYSGC GGNENNFTSK QECLRACKKG FIQRISKGGL IKTKRKRKKQ RVKIAYEEIF 300
  301 VKNM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..193]	PSI-BLAST	24.522879	X-RAY STRUCTURE OF BIKUNIN FROM THE HUMAN INTER-ALPHA-INHIBITOR COMPLEX
2	View Details	[194..304]	PSI-BLAST	10.30103	Tissue factor pathway inhibitor

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
immunoglobulin binding	2.37115313923133	bayes_pls_golite062009
peptidase inhibitor activity	2.16573290057234	bayes_pls_golite062009
binding	1.64118506628038	bayes_pls_golite062009
endopeptidase inhibitor activity	1.5217535137938	bayes_pls_golite062009
serine-type endopeptidase inhibitor activity	1.20182235233856	bayes_pls_golite062009
enzyme inhibitor activity	0.818151972033617	bayes_pls_golite062009
protein complex binding	0.74868021629849	bayes_pls_golite062009
protein binding	0.592299740533878	bayes_pls_golite062009

2

Term	Confidence	Notes
immunoglobulin binding	2.37115313923133	bayes_pls_golite062009
peptidase inhibitor activity	2.16573290057234	bayes_pls_golite062009
binding	1.64118506628038	bayes_pls_golite062009
endopeptidase inhibitor activity	1.5217535137938	bayes_pls_golite062009
serine-type endopeptidase inhibitor activity	1.20182235233856	bayes_pls_golite062009
enzyme inhibitor activity	0.818151972033617	bayes_pls_golite062009
protein complex binding	0.74868021629849	bayes_pls_golite062009
protein binding	0.592299740533878	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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