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Protein Overview: SOS1

General Information:
Name(s) found: SOS1 [HGNC (HUGO)]
Description(s) found:
Found 30 descriptions.
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  • son of sevenless homolog 1 (Drosophila) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1333 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC  60
   61 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 120
  121 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180
  181 EDINILSLTD EEPSTSGEQT YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSAN 240
  241 DVENIFSRIV DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR 300
  301 DILRPGFHDR FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC LHYFELLKQL 360
  361 EEKSEDQEDK ECLKQAITAL LNVQSGMEKI CSKSLAKRRL SESACRFYSQ QMKGKQLAIK 420
  421 KMNEIQKNID GWEGKDIGQC CNEFIMEGTL TRVGAKHERH IFLFDGLMIC CKSNHGQPRL 480
  481 PGASNAEYRL KEKFFMRKVQ INDKDDTNEY KHAFEIILKD ENSVIFSAKS AEEKNNWMAA 540
  541 LISLQYRSTL ERMLDVTMLQ EEKEEQMRLP SADVYRFAEP DSEENIIFEE NMQPKAGIPI 600
  601 IKAGTVIKLI ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLIIERFEI PEPEPTEADR 660
  661 IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH FYDFERDAYL LQRMEEFIGT 720
  721 VRGKAMKKWV ESITKIIQRK KIARDNGPGH NITFQSSPPT VEWHISRPGH IETFDLLTLH 780
  781 PIEIARQLTL LESDLYRAVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV 840
  841 ETENLEERVA VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI 900
  901 LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLKR HGKELINFSK 960
  961 RRKVAEITGE IQQYQNQPYC LRVESDIKRF FENLNPMGNS MEKEFTDYLF NKSLEIEPRN1020
 1021 PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM RHPTPLQQEP RKISYSRIPE SETESTASAP1080
 1081 NSPRTPLTPP PASGASSTTD VCSVFDSDHS SPFHSSNDTV FIQVTLPHGP RSASVSSISL1140
 1141 TKGTDEVPVP PPVPPRRRPE SAPAESSPSK IMSKHLDSPP AIPPRQPTSK AYSPRYSISD1200
 1201 RTSISDPPES PPLLPPREPV RTPDVFSSSP LHLQPPPLGK KSDHGNAFFP NSPSPFTPPP1260
 1261 PQTPSPHGTR RHLPSPPLTQ EVDLHSIAGP PVPPRQSTSQ HIPKLPPKTY KREHTHPSMH1320
 1321 RDGPPLLENA HSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..189] PSI-BLAST 85.0 Crystal Structure of the Histone domain of Son of Sevenless
    2 View Details [190..1035] PSI-BLAST 1000.0 Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)
    3 View Details [1036..1207] FFAS03 1.25 No description for 2j63A was found.
    4 View Details [1208..1333] MSA 2.271993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.84577369534282 bayes_pls_golite062009
  • DNA binding
    		•  2.15812830002368 bayes_pls_golite062009
  • protein binding
    		•  2.1291876005999 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95034158360743 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56724956230377 bayes_pls_golite062009
  • transcription activator activity
    		•  0.60463625072605 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.54706712603347 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.362556145846167 bayes_pls_golite062009
  • transcription factor activity
    		•  0.34457369071872 bayes_pls_golite062009
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  4.97790684877172 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  4.95599897193756 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  4.76052838549234 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.19329722360882 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  3.30632309520479 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  3.0682409213479 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  1.56969272757764 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • protein binding
    		•  1.45048254537577 bayes_pls_golite062009
  • binding
    		•  1.37925410830761 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.887682026452592 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.76425354709916 bayes_pls_golite062009
  • actin binding
    		•  0.586339889144519 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.49424474538279 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.47061801043656 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.470521479239198 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.409825802315921 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.391864697086635 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.362895134105293 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.177619243907855 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.15510703794569 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase docking protein activity
    		•  0.15296158043516 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.0225177299822849 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle