| Protein: | SOS1 |
| Organism: | Homo sapiens |
| Length: | 1333 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOS1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1333] | [1..1333] |
|
|
0.0 | [1..1333] | [266..1598] |
|
|
0.0 | [1..1333] | [1..1333] |
|
|
0.0 | [1..1333] | [1..1319] |
|
|
0.0 | [1..1333] | [186..1504] |
|
|
0.0 | [30..1333] | [39..1342] |
|
Region A: Residues: [1-189] |
1 11 21 31 41 51
| | | | | |
1 MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE LILQLLNMLC 60
61 QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR NPLSLPVEKI HPLLKEVLGY 120
121 KIDHQVSVYI VAVLEYISAD ILKLVGNYVR NIRHYEITKQ DIKVAMCADK VLMDMFHQDV 180
181 EDINILSLT
|
| Detection Method: |  |
| Confidence: | 85.0 |
| Match: | 1q9cA |
| Description: | Crystal Structure of the Histone domain of Son of Sevenless |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.84577369534282 | bayes_pls_golite062009 |
| DNA binding | 2.15812830002368 | bayes_pls_golite062009 |
| protein binding | 2.1291876005999 | bayes_pls_golite062009 |
| nucleic acid binding | 1.95034158360743 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56724956230377 | bayes_pls_golite062009 |
| transcription activator activity | 0.60463625072605 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.54706712603347 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 0.362556145846167 | bayes_pls_golite062009 |
| transcription factor activity | 0.34457369071872 | bayes_pls_golite062009 |
|
Region A: Residues: [190-1035] |
1 11 21 31 41 51
| | | | | |
1 DEEPSTSGEQ TYYDLVKAFM AEIRQYIREL NLIIKVFREP FVSNSKLFSA NDVENIFSRI 60
61 VDIHELSVKL LGHIEDTVEM TDEGSPHPLV GSCFEDLAEE LAFDPYESYA RDILRPGFHD 120
121 RFLSQLSKPG AALYLQSIGE GFKEAVQYVL PRLLLAPVYH CLHYFELLKQ LEEKSEDQED 180
181 KECLKQAITA LLNVQSGMEK ICSKSLAKRR LSESACRFYS QQMKGKQLAI KKMNEIQKNI 240
241 DGWEGKDIGQ CCNEFIMEGT LTRVGAKHER HIFLFDGLMI CCKSNHGQPR LPGASNAEYR 300
301 LKEKFFMRKV QINDKDDTNE YKHAFEIILK DENSVIFSAK SAEEKNNWMA ALISLQYRST 360
361 LERMLDVTML QEEKEEQMRL PSADVYRFAE PDSEENIIFE ENMQPKAGIP IIKAGTVIKL 420
421 IERLTYHMYA DPNFVRTFLT TYRSFCKPQE LLSLIIERFE IPEPEPTEAD RIAIENGDQP 480
481 LSAELKRFRK EYIQPVQLRV LNVCRHWVEH HFYDFERDAY LLQRMEEFIG TVRGKAMKKW 540
541 VESITKIIQR KKIARDNGPG HNITFQSSPP TVEWHISRPG HIETFDLLTL HPIEIARQLT 600
601 LLESDLYRAV QPSELVGSVW TKEDKEINSP NLLKMIRHTT NLTLWFEKCI VETENLEERV 660
661 AVVSRIIEIL QVFQELNNFN GVLEVVSAMN SSPVYRLDHT FEQIPSRQKK ILEEAHELSE 720
721 DHYKKYLAKL RSINPPCVPF FGIYLTNILK TEEGNPEVLK RHGKELINFS KRRKVAEITG 780
781 EIQQYQNQPY CLRVESDIKR FFENLNPMGN SMEKEFTDYL FNKSLEIEPR NPKPLPRFPK 840
841 KYSYPL
|
| Detection Method: | |
| Confidence: | 1000.0 |
| Match: | 1xd4A |
| Description: | Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| GTPase regulator activity | 4.97790684877172 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 4.95599897193756 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 4.76052838549234 | bayes_pls_golite062009 |
| enzyme regulator activity | 4.19329722360882 | bayes_pls_golite062009 |
| small GTPase regulator activity | 3.30632309520479 | bayes_pls_golite062009 |
| Ras guanyl-nucleotide exchange factor activity | 3.0682409213479 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 1.56969272757764 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| protein binding | 1.45048254537577 | bayes_pls_golite062009 |
| binding | 1.37925410830761 | bayes_pls_golite062009 |
| receptor activity | 1.1755016270537 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.1152029796159 | bayes_pls_golite062009 |
| receptor binding | 1.00859318603128 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.887682026452592 | bayes_pls_golite062009 |
| small GTPase binding | 0.8507658747425 | bayes_pls_golite062009 |
| GTPase binding | 0.82889812790119 | bayes_pls_golite062009 |
| insulin receptor binding | 0.76425354709916 | bayes_pls_golite062009 |
| actin binding | 0.586339889144519 | bayes_pls_golite062009 |
| protein complex binding | 0.55916857709427 | bayes_pls_golite062009 |
| beta-amyloid binding | 0.49424474538279 | bayes_pls_golite062009 |
| SH2 domain binding | 0.47061801043656 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.470521479239198 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.409825802315921 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.391864697086635 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 0.362895134105293 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 0.177619243907855 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 0.15510703794569 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase docking protein activity | 0.15296158043516 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.10105990547756 | bayes_pls_golite062009 |
| enzyme activator activity | 0.0225177299822849 | bayes_pls_golite062009 |
|
Region A: Residues: [1036-1207] |
1 11 21 31 41 51
| | | | | |
1 KSPGVRPSNP RPGTMRHPTP LQQEPRKISY SRIPESETES TASAPNSPRT PLTPPPASGA 60
61 SSTTDVCSVF DSDHSSPFHS SNDTVFIQVT LPHGPRSASV SSISLTKGTD EVPVPPPVPP 120
121 RRRPESAPAE SSPSKIMSKH LDSPPAIPPR QPTSKAYSPR YSISDRTSIS DP
|
| Detection Method: | |
| Confidence: | 1.25 |
| Match: | 2j63A |
| Description: | No description for 2j63A was found. |
|
Region A: Residues: [1208-1333] |
1 11 21 31 41 51
| | | | | |
1 PESPPLLPPR EPVRTPDVFS SSPLHLQPPP LGKKSDHGNA FFPNSPSPFT PPPPQTPSPH 60
61 GTRRHLPSPP LTQEVDLHSI AGPPVPPRQS TSQHIPKLPP KTYKREHTHP SMHRDGPPLL 120
121 ENAHSS
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
