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Protein Overview: PPIA

General Information:
Name(s) found: PPIA [HGNC (HUGO)]
Description(s) found:
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  • gi|2981764|pdb|1AWV|F Chain F, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981763|pdb|1AWV|E Chain E, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981762|pdb|1AWV|D Chain D, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981761|pdb|1AWV|C Chain C, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981760|pdb|1AWV|B Chain B, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981759|pdb|1AWV|A Chain A, Cypa Complexed With Hvgpia [NCBI NR]
  • gi|2981757|pdb|1AWU|A Chain A, Cypa Complexed With Hvgpia (Pseudo-Symmetric Monomer) [NCBI NR]
  • gi|2981736|pdb|1AWR|F Chain F, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981735|pdb|1AWR|E Chain E, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981734|pdb|1AWR|D Chain D, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981733|pdb|1AWR|C Chain C, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981732|pdb|1AWR|B Chain B, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981731|pdb|1AWR|A Chain A, Cypa Complexed With Hagpia [NCBI NR]
  • gi|2981729|pdb|1AWQ|A Chain A, Cypa Complexed With Hagpia (Pseudo-Symmetric Monomer) [NCBI NR]
  • gi|1827593|pdb|1RMH|B Chain B, Recombinant Cyclophilin A From Human T Cell [NCBI NR]
  • gi|1827592|pdb|1RMH|A Chain A, Recombinant Cyclophilin A From Human T Cell [NCBI NR]
  • gi|1633063|pdb|2CYH|A Chain A, Cyclophilin A Complexed With Dipeptide Ala-Pro [NCBI NR]
  • gi|1633058|pdb|3CYH|A Chain A, Cyclophilin A Complexed With Dipeptide Ser-Pro [NCBI NR]
  • gi|1633056|pdb|4CYH|A Chain A, Cyclophilin A Complexed With Dipeptide His-Pro [NCBI NR]
  • gi|1633054|pdb|5CYH|A Chain A, Cyclophilin A Complexed With Dipeptide Gly-Pro [NCBI NR]
  • peptidylprolyl isomerase A (cyclophilin A) [HGNC (HUGO)]
  • (P62937) Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8) (PPIase A) (Rotamase A) (Cyclophilin A) (Cyclosporin A-binding protein) [Swiss-Prot]
  • Peptidyl-prolyl cis-trans isomerase A [hmr_yeast5_DM3-1_pombe.fasta]
  • Chain F, Cypa Complexed With Hvgpiagi|2981763|pdb|1AWV|E Chain E, Cypa Complexed With Hvgpiagi|2981762|pdb|1AWV|D Chain D, Cypa Complexed With Hvgpiagi|2981761|pdb|1AWV|C Chain C, Cypa Complexed With Hvgpiagi|2981760|pdb|1AWV|B Chain B, Cypa Complexed [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Peptidyl-prolyl cis-trans isomerase A [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • Chain F, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain E, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain D, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain C, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cypa Complexed With Hvgpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cypa Complexed With Hvgpia (Pseudo-Symmetric Monomer) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain F, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain E, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain D, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain C, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cypa Complexed With Hagpia [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cypa Complexed With Hagpia (Pseudo-Symmetric Monomer) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Recombinant Cyclophilin A From Human T Cell [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Recombinant Cyclophilin A From Human T Cell [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cyclophilin A Complexed With Dipeptide Ala-Pro [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cyclophilin A Complexed With Dipeptide Ser-Pro [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cyclophilin A Complexed With Dipeptide His-Pro [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Cyclophilin A Complexed With Dipeptide Gly-Pro [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • [GiardiaDB-3.1_GintestinalisAssemblageA_AnnotatedProteinsPlusCrap.fasta]
  • PPIA OS=HUMAN GN=None PE=None SV=None [eshark_proteins_plusContam.fa]
    • Organism: Homo sapiens
    Length: 164 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNPTVFFDIA VDGEPLGRVS FELFADKVPK TAENFRALST GEKGFGYKGS CFHRIIPGFM  60
   61 CQGGDFTRHN GTGGKSIYGE KFEDENFILK HTGPGILSMA NAGPNTNGSQ FFICTAKTEW 120
  121 LDGKHVVFGK VKEGMNIVEA MERFGSRNGK TSKKITIADC GQLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. PPIA gi|112491310 gi|13786858 gi|219109210, gi...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164] PSI-BLAST 70.69897 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle