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Protein Overview: PSMD10

General Information:
Name(s) found: PSMD10 [HGNC (HUGO)]
Description(s) found:
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  • gi|56966093|pdb|1TR4|A Chain A, Solution Structure Of Human Oncogenic Protein Gankyrin [NCBI NR]
  • gi|4506217|ref|NP_002805.1| proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|4176498|emb|CAA20117.1| proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Homo sapiens] [NCBI NR]
  • gi|3893155|dbj|BAA34594.1| gankyrin [Homo sapiens] [NCBI NR]
  • gi|38493072|pdb|1UOH|A Chain A, Human Gankyrin [NCBI NR]
  • gi|3618345|dbj|BAA33215.1| 26S proteasome subunit p28 [Homo sapiens] [NCBI NR]
  • gi|20532206|sp|O75832.1|PSD10_HUMAN RecName: Full=26S proteasome non-ATPase regulatory subunit 10; AltName: Full=26S proteasome regulatory subunit p28; AltName: Full=Gankyrin [NCBI NR]
  • gi|159163069|pdb|1TR4|A Chain A, Solution Structure Of Human Oncogenic Protein Gankyrin [NCBI NR]
  • gi|15080417|gb|AAH11960.1| Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Homo sapiens] [NCBI NR]
  • gi|119623102|gb|EAX02697.1| proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, isoform CRA_a [Homo sapiens] [NCBI NR]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [HGNC (HUGO)]
  • (O75832) 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) [Swiss-Prot]
  • 26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens GN=PSMD10 PE=1 SV=1 [Swiss-Prot]
  • 26S proteasome non-ATPase regulatory subunit 10 [hmr_yeast5_DM3-1_pombe.fasta]
  • proteasome 26S non-ATPase subunit 10 isoform 1; ankyrin repeat protein; gankyrin; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II [HMR_022704.fasta]
  • proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens]gi|15080417|gb|AAH11960.1| Proteasome 26S non-ATPase subunit 10, isoform 1 [Homo sapiens]gi|3893155|dbj|BAA34594.1| gankyrin [Homo sapiens]gi|4176498|emb|CAA20117.1| dJ889N15.2.1 (26S Proteas [nrdb_11152004_Chlamydomonas]
  • 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 26S proteasome non-ATPase regulatory subunit 10 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_002814) proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • proteasome 26S non-ATPase subunit 10 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • proteasome 26S non-ATPase subunit 10 isoform 1; ankyrin repeat protein; gankyrin; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II [Homo sapiens] [HumanGallus06162005.fasta]
  • Chain A, Solution Structure Of Human Oncogenic Protein Gankyrin [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Gankyrin [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • gankyrin [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • 26S proteasome subunit p28 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=26S proteasome non-ATPase regulatory subunit 10; AltName: Full=26S proteasome regulatory subunit p28; AltName: Full=Gankyrin [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PSMD10 26S proteasome non-ATPase regulatory subunit 10 [human-ipi-250309-contam.fasta]
  • IPI:IPI00003565.1|SWISS-PROT:O75832|TREMBL:Q5U0B2|ENSEMBL:ENSP00000217958|REFSEQ:NP_002805|H-INV:HIT000101791|VEGA:OTTHUMP00000023827 Tax_Id=9606 Gene_Symbol=PSMD10 26S proteasome non-ATPase regulatory subunit 10 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PSMD10 26S proteasome non-ATPase regulatory subunit 10 ENSG00000101843 IPI00003565 IPI00552808 IPI00027699 IPI00183104 IPI00552190 IPI00647839 [drosphohumanreversed.fasta]
  • O75832; RecName: Full=26S proteasome non-ATPase regulatory subunit 10; AltName: Full=26S proteasome regulatory subunit p28; AltName: Full=Gankyrin; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • 26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens GN=PSMD10 [011711_HMR.fasta]
  • GeneSymbol=PSMD10 Synonyms=dJ889N15.2|p28|p28(GANK) 26S proteasome non-ATPase regulatory subunit 10 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • 26S proteasome non-ATPase regulatory subunit 10 GN=PSMD10 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 226 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL  60
   61 QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE 120
  121 IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC 180
  181 DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. PSMD10 gi|112491310 gi|13786858 gi|14277752, gi|... gi|150261449 gi|219109210, gi... gi|3659984 gi|56554577 gi|56966260, gi|...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 50.69897 Solution structure of human oncogenic protein gankyrin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • binding
    		•  2.41068257517762 bayes_pls_golite062009
  • structural molecule activity
    		•  2.02593487630436 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.93050618316228 bayes_pls_golite062009
  • protein binding
    		•  1.54890102798695 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.29094941611102 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.327689573161126 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.280340492381105 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • actin binding
    		•  0.168912685840912 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.0462605323512499 bayes_pls_golite062009
  • DNA binding
    		•  0.0016834194928852 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle