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Protein Overview: gi|4505573, gi|1...

General Information:
Name(s) found: gi|4505573 [NCBI NR]
gi|166064038 [NCBI NR]
gi|123245105 [NCBI NR]
gi|122889256 [NCBI NR]
gi|119629554 [NCBI NR]
gi|119629549 [NCBI NR]
gi|119629548 [NCBI NR]
Description(s) found:
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  • gi|4505573|ref|NP_003890.1| PAK-interacting exchange factor beta isoform a [Homo sapiens] [NCBI NR]
  • gi|166064038|ref|NP_001106985.1| PAK-interacting exchange factor beta isoform a [Homo sapiens] [NCBI NR]
  • gi|123245105|emb|CAM20788.1| Rho guanine nucleotide exchange factor (GEF) 7 [Homo sapiens] [NCBI NR]
  • gi|122889256|emb|CAM13628.1| Rho guanine nucleotide exchange factor (GEF) 7 [Homo sapiens] [NCBI NR]
  • gi|119629554|gb|EAX09149.1| Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119629549|gb|EAX09144.1| Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119629548|gb|EAX09143.1| Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b [Homo sapiens] [NCBI NR]
  • Rho guanine nucleotide exchange factor 7 [hmr_yeast5_DM3-1_pombe.fasta]
  • Rho guanine nucleotide exchange factor 7 isoform a; SH3 domain-containing proline-rich protein; PAK-interacting exchange factor beta [HMR_022704.fasta]
  • Rho guanine nucleotide exchange factor 7 isoform a [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform 1 of Rho guanine nucleotide exchange factor 7 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003899) Rho guanine nucleotide exchange factor 7 isoform a; SH3 domain-containing proline-rich protein; PAK-interacting exchange factor beta [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Rho guanine nucleotide exchange factor 7 isoform a; SH3 domain-containing proline-rich protein; PAK-interacting exchange factor beta [Homo sapiens] [HumanGallus06162005.fasta]
  • PAK-interacting exchange factor beta isoform a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Rho guanine nucleotide exchange factor (GEF) 7 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Rho guanine nucleotide exchange factor 7 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=ARHGEF7 Isoform 1 of Rho guanine nucleotide exchange factor 7 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Isoform 1 of Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 [011711_HMR.fasta]
  • IPI:IPI00945115.1|SWISS-PROT:Q14155-1|TREMBL:Q5ZEZ2|ENSEMBL:ENSP00000364888;ENSP00000397068|REFSEQ:NP_001106985;NP_003890|VEGA:OTTHUMP00000178803 Tax_Id=9606 Gene_Symbol=ARHGEF7 Isoform 1 of Rho guanine nucleotide exchange factor 7 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=ARHGEF7 Synonyms=BETA-PIX|COOL-1|COOL1|DKFZp686C12170|DKFZp761K1021|KIAA0142|KIAA0412|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB rho guanine nucleotide exchange factor 7 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00947263.2|SWISS-PROT:Q14155-1|TREMBL:Q5ZEZ2|ENSEMBL:ENSP00000364888;ENSP00000397068|REFSEQ:NP_001106985;NP_003890|VEGA:OTTHUMP00000018717;OTTHUMP00000178803 Tax_Id=9606 Gene_Symbol=ARHGEF7 Isoform 1 of Rho guanine nucleotide exchange factor 7 [ipi.HUMAN.20110912.fasta]
  • Isoform 1 of Rho guanine nucleotide exchange factor 7 GN=ARHGEF7 [Doctor+uniprot-HUMAN-120911.fasta]
  • Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b OS=Homo sapiens GN=ARHGEF7 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
  • Isoform of Q14155, Isoform 1 of Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 [2016-04-human-contam-aPKC-His-Par6.fasta]
    • Organism: Homo sapiens
    Length: 646 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV  60
   61 REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN ILETENEYSK ELQTVLSTYL 120
  121 RPLQTSEKLS SANISYLMGN LEEICSFQQM LVQSLEECTK LPEAQQRVGG CFLNLMPQMK 180
  181 TLYLTYCANH PSAVNVLTEH SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK 240
  241 ELERHMEDYH TDRQDIQKSM AAFKNLSAQC QEVRKRKELE LQILTEAIRN WEGDDIKTLG 300
  301 NVTYMSQVLI QCAGSEEKNE RYLLLFPNVL LMLSASPRMS GFIYQGKLPT TGMTITKLED 360
  361 SENHRNAFEI SGSMIERILV SCNNQQDLQE WVEHLQKQTK VTSVGNPTIK PHSVPSHTLP 420
  421 SHPVTPSSKH ADSKPAPLTP AYHTLPHPSH HGTPHTTINW GPLEPPKTPK PWSLSCLRPA 480
  481 PPLRPSAALC YKEDLSKSPK TMKKLLPKRK PERKPSDEEF ASRKSTAALE EDAQILKVIE 540
  541 AYCTSAKTRQ TLNSSSRKES APQVLLPEEE KIIVEETKSN GQTVIEEKSL VDTVYALKDE 600
  601 VQELRQDNKK MKKSLEEEQR ARKDLEKLVR KVLKNMNDPA WDETNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] PSI-BLAST 9.69897 beta PIX-SH3 complexed with an atypical peptide from alpha-PAK
    2 View Details [74..163] PSI-BLAST 18.39794 beta-pix
    3 View Details [164..291] PSI-BLAST 10.30103 No description for 2hwoA was found.
    4 View Details [292..403] PSI-BLAST 13.154902 Solution Structure of the Pleckstrin Homology Domain of alpha-Pix
    5 View Details [404..558] MSA 2.668996 View MSA. No confident structure predictions are available.
    6 View Details [559..646] MSA 1.116991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  5.11074603459714 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  5.08847923392129 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  4.86840565991411 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  4.48792387237937 bayes_pls_golite062009
  • enzyme regulator activity
    		•  4.3439350617225 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  4.34078803610551 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  4.20362774065877 bayes_pls_golite062009
  • binding
    		•  2.72918942472263 bayes_pls_golite062009
  • protein binding
    		•  1.55620082928053 bayes_pls_golite062009
  • signal transducer activity
    		•  1.38049306661118 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.38049306661118 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.752349454878473 bayes_pls_golite062009
  • receptor binding
    		•  0.540147469472769 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.535089791137297 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.453716946272335 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.451744196693003 bayes_pls_golite062009
  • small GTPase binding
    		•  0.40881922277547 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.401233613072731 bayes_pls_golite062009
  • GTPase binding
    		•  0.38955577404416 bayes_pls_golite062009
  • DNA binding
    		•  0.313566245805362 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.27856999050234 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  0.211048635764309 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • profilin binding
    		•  1.13790597338922 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • transporter activity
    		•  0.882299675921716 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.570303292760019 bayes_pls_golite062009
  • receptor binding
    		•  0.50127063593663 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.47853225730469 bayes_pls_golite062009
  • receptor activity
    		•  0.353510125274044 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.324566338715835 bayes_pls_golite062009
  • actin binding
    		•  0.3076498786796 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.207829786337892 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.13700176999256 bayes_pls_golite062009
  • DNA binding
    		•  0.136435190086451 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.118897432176337 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009
  • beta-amyloid binding
    		•  0.0597358198128299 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle