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View Structure Prediction Details

Protein: gi|4505573, gi|1...
Organism: Homo sapiens
Length: 646 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|4505573, gi|1....

Description E-value Query
Range		 Subject
Range
gi|114650706 - gi|114650706|ref|XP_509742.2| PREDICTED: Rho guanine nucleotide exchange factor 7 [Pan troglodytes]
 0.0 [1..646] [256..901]
gi|40788881 - gi|40788881|dbj|BAA09763.2| KIAA0142 [Homo sapiens]
 0.0 [1..646] [157..802]
gi|2098783 - gi|2098783|gb|AAB57691.1| p85SPR [Mus musculus]
 0.0 [1..646] [1..646]
gi|73989539 - gi|73989539|ref|XP_542671.2| PREDICTED: similar to Rho guanine nucleotide exchange factor 7 isoform ...
 0.0 [1..646] [248..952]
ARHG7_RAT - Rho guanine nucleotide exchange factor 7 OS=Rattus norvegicus GN=Arhgef7 PE=1 SV=1
 0.0 [1..646] [1..646]
gi|50730554 - gi|50730554|ref|XP_416958.1| PREDICTED: similar to Rho guanine nucleotide exchange factor 7 (PAK-int...
 0.0 [125..646] [749..1270]

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Predicted Domain #1
Region A:
Residues: [1-73] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV  60
   61 REVKASEKPV SPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1zsgA
Description: beta PIX-SH3 complexed with an atypical peptide from alpha-PAK
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [74-163] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGTLKSPPKG FDTTAINKSY YNVVLQNILE TENEYSKELQ TVLSTYLRPL QTSEKLSSAN  60
   61 ISYLMGNLEE ICSFQQMLVQ SLEECTKLPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 1by1A
Description: beta-pix
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 5.11074603459714 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 5.08847923392129 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 4.86840565991411 bayes_pls_golite062009
small GTPase regulator activity 4.48792387237937 bayes_pls_golite062009
enzyme regulator activity 4.3439350617225 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 4.34078803610551 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 4.20362774065877 bayes_pls_golite062009
binding 2.72918942472263 bayes_pls_golite062009
protein binding 1.55620082928053 bayes_pls_golite062009
signal transducer activity 1.38049306661118 bayes_pls_golite062009
molecular transducer activity 1.38049306661118 bayes_pls_golite062009
GTPase activator activity 0.752349454878473 bayes_pls_golite062009
receptor binding 0.540147469472769 bayes_pls_golite062009
transcription regulator activity 0.535089791137297 bayes_pls_golite062009
enzyme activator activity 0.453716946272335 bayes_pls_golite062009
Ras GTPase activator activity 0.451744196693003 bayes_pls_golite062009
small GTPase binding 0.40881922277547 bayes_pls_golite062009
nucleic acid binding 0.401233613072731 bayes_pls_golite062009
GTPase binding 0.38955577404416 bayes_pls_golite062009
DNA binding 0.313566245805362 bayes_pls_golite062009
cytoskeletal protein binding 0.27856999050234 bayes_pls_golite062009
Rho GTPase activator activity 0.211048635764309 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [164-291] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQQRVGGCFL NLMPQMKTLY LTYCANHPSA VNVLTEHSEE LGEFMETKGA SSPGILVLTT  60
   61 GLSKPFMRLD KYPTLLKELE RHMEDYHTDR QDIQKSMAAF KNLSAQCQEV RKRKELELQI 120
  121 LTEAIRNW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.30103
Match: 2hwoA
Description: No description for 2hwoA was found.

Predicted Domain #4
Region A:
Residues: [292-403] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGDDIKTLGN VTYMSQVLIQ CAGSEEKNER YLLLFPNVLL MLSASPRMSG FIYQGKLPTT  60
   61 GMTITKLEDS ENHRNAFEIS GSMIERILVS CNNQQDLQEW VEHLQKQTKV TS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 1v61A
Description: Solution Structure of the Pleckstrin Homology Domain of alpha-Pix
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.29080729281876 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
profilin binding 1.13790597338922 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
transporter activity 0.882299675921716 bayes_pls_golite062009
small GTPase binding 0.8507658747425 bayes_pls_golite062009
GTPase binding 0.82889812790119 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
cytoskeletal protein binding 0.570303292760019 bayes_pls_golite062009
receptor binding 0.50127063593663 bayes_pls_golite062009
substrate-specific transporter activity 0.47853225730469 bayes_pls_golite062009
receptor activity 0.353510125274044 bayes_pls_golite062009
transcription regulator activity 0.324566338715835 bayes_pls_golite062009
actin binding 0.3076498786796 bayes_pls_golite062009
transmembrane receptor activity 0.207829786337892 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.13700176999256 bayes_pls_golite062009
DNA binding 0.136435190086451 bayes_pls_golite062009
nucleic acid binding 0.118897432176337 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
beta-amyloid binding 0.0597358198128299 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [404-558] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGNPTIKPHS VPSHTLPSHP VTPSSKHADS KPAPLTPAYH TLPHPSHHGT PHTTINWGPL  60
   61 EPPKTPKPWS LSCLRPAPPL RPSAALCYKE DLSKSPKTMK KLLPKRKPER KPSDEEFASR 120
  121 KSTAALEEDA QILKVIEAYC TSAKTRQTLN SSSRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [559-646] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESAPQVLLPE EEKIIVEETK SNGQTVIEEK SLVDTVYALK DEVQELRQDN KKMKKSLEEE  60
   61 QRARKDLEKL VRKVLKNMND PAWDETNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle