Protein Overview: PAN6

General Information:
Name(s) found:	PAN6 / YIL145C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|84028236\|sp\|P40459.2\|PANC_YEAST RecName: Full=Pantoate--beta-alanine ligase; AltName: Full=Pantothenate synthetase; AltName: Full=Pantoate-activating enzyme [NCBI NR] gi\|37362661\|ref\|NP_012121.2\| Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; Pan6p [Saccharomyces cerevisiae] [NCBI NR] Pantoate--beta-alanine ligase OS=Saccharomyces cerevisiae GN=PAN6 PE=1 SV=2 [Swiss-Prot] PAN6 Protein required for synthesis of pantothenic acid [mips] Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC [SGD] Chr IX from 77283-76354, reverse complement [yeastorf5.fasta] PAN6 SGDID:S0001407, Chr IX from 77283-76354, reverse complement, Verified ORF [yeastflysequest.fasta] Pan6p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] PAN6 SGDID:S000001407, Chr IX from 77283-76354, reverse complement, Verified ORF, "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC; Pan6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme) [nr-271106-contam.fasta] PAN6 SGDID:S000001407, Chr IX from 77283-76354, reverse complement, Verified ORF, "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Pantoate--beta-alanine ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN6 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PAN6 SGDID:S000001407, Chr IX from 77283-76354, Genome Release 64-1-1, reverse complement, Verified ORF, "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" [yeast-030211-contam.fasta] PAN6 SGDID:S000001407, Chr IX from 77283-76354, Genome Release 64-2-1, reverse complement, Verified ORF, "Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" [20141208_orf_trans.fasta] YIL145C SGDID:S000001407, Chr IX from 77283-76354, Genome Release 64-1-1, reverse complement, Verified ORF, "Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	pantothenate biosynthetic process [IMP]
Molecular Function:	pantoate-beta-alanine ligase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE NTYTVVSIFV  60
   61 NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV MYPQGIPLDI EEQKGPFVSV 120
  121 LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV MADVAYFGQK DIQQFIVLQC MVDELFVNTR 180
  181 LQMMPIVRNN NGLALSSRNK YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID 240
  241 TVTQIWAPYV DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 300
  301 VRLIDNIVI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#14 Mitotic Prep2-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RRB1	PAN6	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PAN6	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..309]	PSI-BLAST	101.0	Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	5.66762539052452	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	5.66762539052452	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	5.65398773296369	bayes_pls_golite062009
ligase activity	4.61911329839139	bayes_pls_golite062009
pantoate-beta-alanine ligase activity	2.65346774278189	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.21467185575886	bayes_pls_golite062009
nucleic acid binding	1.64840822019417	bayes_pls_golite062009
methionine-tRNA ligase activity	1.59260025359667	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.47110858685627	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.38579849961344	bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity	1.25694296916214	bayes_pls_golite062009
binding	1.11291710031577	bayes_pls_golite062009
adenylyltransferase activity	1.08055019963499	bayes_pls_golite062009
transferase activity	1.06817715108743	bayes_pls_golite062009
tryptophan-tRNA ligase activity	0.725178047574893	bayes_pls_golite062009
arginine-tRNA ligase activity	0.722005407734432	bayes_pls_golite062009
nicotinate-nucleotide adenylyltransferase activity	0.692499879958128	bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity	0.567882194154248	bayes_pls_golite062009
nucleotidyltransferase activity	0.564359271862248	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.430902479559327	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2