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Protein Overview: PAN6

General Information:
Name(s) found: PAN6 / YIL145C [SGD]
Description(s) found:
Found 17 descriptions.
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  • Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 309 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: pantothenate biosynthetic process [IMPLink to PubMed article]
    Molecular Function: pantoate-beta-alanine ligase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE NTYTVVSIFV  60
   61 NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV MYPQGIPLDI EEQKGPFVSV 120
  121 LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV MADVAYFGQK DIQQFIVLQC MVDELFVNTR 180
  181 LQMMPIVRNN NGLALSSRNK YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID 240
  241 TVTQIWAPYV DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 300
  301 VRLIDNIVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PAN6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] PSI-BLAST 101.0 Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  5.66762539052452 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  5.66762539052452 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  5.65398773296369 bayes_pls_golite062009
  • ligase activity
    		•  4.61911329839139 bayes_pls_golite062009
  • pantoate-beta-alanine ligase activity
    		•  2.65346774278189 bayes_pls_golite062009
  • catalytic activity
    		•  2.37674226834122 bayes_pls_golite062009
  • glutamate-tRNA ligase activity
    		•  2.21467185575886 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64840822019417 bayes_pls_golite062009
  • methionine-tRNA ligase activity
    		•  1.59260025359667 bayes_pls_golite062009
  • tyrosine-tRNA ligase activity
    		•  1.47110858685627 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.38579849961344 bayes_pls_golite062009
  • pantetheine-phosphate adenylyltransferase activity
    		•  1.25694296916214 bayes_pls_golite062009
  • binding
    		•  1.11291710031577 bayes_pls_golite062009
  • adenylyltransferase activity
    		•  1.08055019963499 bayes_pls_golite062009
  • transferase activity
    		•  1.06817715108743 bayes_pls_golite062009
  • tryptophan-tRNA ligase activity
    		•  0.725178047574893 bayes_pls_golite062009
  • arginine-tRNA ligase activity
    		•  0.722005407734432 bayes_pls_golite062009
  • nicotinate-nucleotide adenylyltransferase activity
    		•  0.692499879958128 bayes_pls_golite062009
  • nicotinamide-nucleotide adenylyltransferase activity
    		•  0.567882194154248 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.564359271862248 bayes_pls_golite062009
  • cysteine-tRNA ligase activity
    		•  0.430902479559327 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle