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Protein Overview: UBP14

General Information:
Name(s) found: UBP14 / YBR058C [SGD]
Description(s) found:
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  • gi|37362616|ref|NP_009614.2| Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; Ubp14p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|118597230|sp|P38237.2|UBP14_YEAST RecName: Full=Ubiquitin carboxyl-terminal hydrolase 14; AltName: Full=Ubiquitin thioesterase 14; AltName: Full=Ubiquitin-specific-processing protease 14; AltName: Full=Deubiquitinating enzyme 14; AltName: Full=Glucose- [NCBI NR]
  • Ubiquitin carboxyl-terminal hydrolase 14 OS=Saccharomyces cerevisiae GN=UBP14 PE=1 SV=2 [Swiss-Prot]
  • UBP14 Ubiquitin specific protease [mips]
  • Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T [SGD]
  • Chr II from 355976-353631, reverse complement [yeastorf5.fasta]
  • UBP14 SGDID:S0000262, Chr II from 355977-353632, reverse complement, Verified ORF [yeastflysequest.fasta]
  • UBP14 SGDID:S0000262, Chr II from 356015-353670, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (FBPase) degradation [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • UBP14 SGDID:S000000262, Chr II from 356015-353670, reverse complement, Verified ORF, "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human iso [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; Ubp14p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • UBP14 SGDID:S000000262, Chr II from 356015-353670, reverse complement, Verified ORF, "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP14 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UBP14 SGDID:S000000262, Chr II from 356017-353672, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" [yeast-030211-contam.fasta]
  • UBP14 SGDID:S000000262, Chr II from 356017-353672, Genome Release 64-2-1, reverse complement, Verified ORF, "Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" [20141208_orf_trans.fasta]
  • YBR058C SGDID:S000000262, Chr II from 356017-353672, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 781 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    negative regulation of gluconeogenesis [IMPLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEAVLENVN VPAVVSKDEC IYCFESPYNE PLALNASPKH SLNICLNCFQ ATCNRHVPLH  60
   61 IRVTEYACDT IHSNYLTIAK VEKPKQENVE ENNNNKKIKL QVIETSEDDT HNTIWSLQRF 120
  121 NGENVPRTVL SKSTDSDISS TALEKIEKIL KAKSQDFEDK KNSWVLEIST CPHTENFQIP 180
  181 SKPENTVNLN QCSSCDLTQN LWLCLHCGNI GCGREQIGID GHSHALDHYR SNNNHPLAIK 240
  241 LGSLSSSTYD LYCYACDDET RFPDNVNLGS ALQIYGINIQ EKIADEKTLV QLQVEQNENW 300
  301 QFRMVDSSGK EFEKLSASKN YGCGLINLGN SCYLNSVIQS LVNGGVPNWS LDFLGSKFPL 360
  361 DVVYPDNNLK CQWIKLLNAM KCEPELYPNG IKPTTFKKCI GQNHQEFSSN RQQDAMEFLT 420
  421 FLLDLLDKKF FSSSSSGIPN PNDLVRFMME DRLQCNICGK VKYSYEPTEA IQIPLEENDE 480
  481 PQDMLERIKA YFEGQTIEFK CANCKEKVTA NKKPGFKSLP QTLILNPIRI RLQNWIPVKT 540
  541 SNELSLPGLI DRDDMLDVSS YLSQGFDPQT ENLLPDEDEN RSSFTPNQCS ISQLIEMGFT 600
  601 QNASVRALFN TGNQDAESAM NWLFQHMDDP DLNDPFVPPP NVPKKDKREV DEVSLTSMLS 660
  661 MGLNPNLCRK ALILNNGDVN RSVEWVFNNM DDDGTFPEPE VPNEEQQQKK DLGYSTAKPY 720
  721 ALTAVICHKG NSVHSGHYVV FIRKLVADKW KWVLYNDEKL VAADSIEDMK KNGYIYFYTR 780
  781 C

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CYC8 SEC16 UBP14
    View Details Gavin AC, et al. (2002) ADH1 ILS1 NIP1 UBP14

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data UBP14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] deduced N/A No confident structure predictions are available.
    2 View Details [140..295] Pfam 30.387216 No description for PF02148.6 was found. No confident structure predictions are available.
    3 View Details [296..700] PSI-BLAST 36.522879 Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
    4 View Details [701..781] MSA 19.251996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle