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Protein Overview: UCHL3

General Information:
Name(s) found: UCHL3 [HGNC (HUGO)]
Description(s) found:
Found 45 descriptions.
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  • ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 230 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE  60
   61 KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 120
  121 KFLEESVSMS PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL 180
  181 YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. UCHL3 gi|112491310 gi|219109210, gi...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] PSI-BLAST 104.0 DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.96735553959103 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • omega peptidase activity
    		•  1.7955048939859 bayes_pls_golite062009
  • binding
    		•  1.77258741259391 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • tubulin binding
    		•  0.75490638344179 bayes_pls_golite062009
  • microtubule binding
    		•  0.737305952322311 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • signal transducer activity
    		•  0.32811477573477 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.32811477573477 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.168761518285256 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle