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Protein Overview: AXL1

General Information:
Name(s) found: AXL1 / YPR122W [SGD]
Description(s) found:
Found 19 descriptions.
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  • Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1208 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck [IDALink to PubMed article]
    integral to membrane [TASLink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: axial cellular bud site selection [TASLink to PubMed article]
    cellular bud site selection [TASLink to PubMed article]
    conjugation with cellular fusion [NASLink to PubMed articleLink to PubMed article]
    peptide pheromone maturation [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: metalloendopeptidase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLREVTNYE VSFYIPLSYS NRTHKVCKLP NGILALIISD PTDTSSSCSL TVCTGSHNDP  60
   61 KDIAGLAHLC EHMILSAGSK KYPDPGLFHT LIAKNNGSQN AFTTGEQTTF YFELPNTQNN 120
  121 GEFTFESILD VFASFFKEPL FNPLLISKEI YAIQSEHEGN ISSTTKIFYH AARILANPDH 180
  181 PFSRFSTGNI HSLSSIPQLK KIKLKSSLNT YFENNFFGEN ITLCIRGPQS VNILTKLALS 240
  241 KFGDIKPKSA VKERSISIRT RSFRRSKSLK KRQDSSKNDY SDLKTFKILN TTWEKKYKNT 300
  301 MCFQQFPECN SIFINSNKVP IMRLLFPVSD KNTRFTKDDI KIYSHLWCEL FGDESPGSLS 360
  361 YYLASKGWLT GCFAFTSEFA IGDIGLILEL ELTNSGWENI KRITTIVLNR LLPSFYVMNI 420
  421 DYLITFLKEQ NLIDLVSFLY QSSEDLPMEE CSKLSGILQD DLECLTPPNI FKGFKSLIEI 480
  481 DDPNIEKYEN TKANIQWWTG QAIKFQNFLK SFMNHDNMRL LLLGNIKSGN IFDKMKNKSD 540
  541 ICTDFFYEFE YYTANVHLAS DNKFHSNSSY EFNFPTGNLF LPDCVSDPLK LQQLFLECSL 600
  601 KSKFATLRPQ IYSEPTRTKP QLVSENQNYE MWILKEDPNF ASDNKSVVSF EVLGLGIKPS 660
  661 PEATIHLEVL AQALFIITSS FLYPALRIGY TYEIASSSKG NVTLRFTISG FPEGVFTIVK 720
  721 TFVDTLKLIA TDPTFLSKDT LRKARILVRN KYKNASSDNC VKLASVGLLI VLEKYIWTLE 780
  781 DRINALELTE LESFEKFCFL FWRNPKHLVL FMQGSLEYAD AINRYLNNNF TQHLKISNEG 840
  841 SKPTIRLYPP PSTKDLDQGT NAFISYNGHQ DDPNNSIVYF IQTAQRDDIK NLTLTFLTEY 900
  901 LFSLTLVPDL RNKKQIGYIV LGGLRVLTDT VGIHITVMSG SSGHNLETRI NEYLSYLQLQ 960
  961 VLNRFTEFDF RRILLEPFLN LLKQNSTKQF EGSAGPVDLL NEIVANVQNG DNYTLNNKQM1020
 1021 RQHRKVRNKI AEGRLNFQED HEMIDISFLQ KLTLKKYLAF FESKISIYSA QRSKLSIMIT1080
 1081 SPMAEKEIAS RKMFLQLEAF LKINGFAIKN EDLKKIVEHS KGNPILLVKN LFTYFRRRNE1140
 1141 VFKLGTVVLQ EILKIIGMNL KQRYGSILGF SSQDGEGQEI EKFWNNDTSP IVPLQELPEP1200
 1201 NFFRKAAF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ALA1 AXL1 DBF20 EGD2 GPH1 IDH2 MOB1 RPB10

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEX1 AXL1 2 Unpublished Fields Lab Data
    View Screen MET18 AXL1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AXL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161]
    [180..260]
    [441..471]    		 PSI-BLAST 128.9794 Mitochondrial processing peptidase (MPP) beta chain
    2 View Details [162..179]
    [261..440]    		 PSI-BLAST 128.9794 Mitochondrial processing peptidase (MPP) beta chain
    3 View Details [472..568] deduced N/A No confident structure predictions are available.
    4 View Details [569..1011] MSA 2.050951 View MSA. No confident structure predictions are available.
    5 View Details [1012..1121] MSA 1.041989 View MSA. No confident structure predictions are available.
    6 View Details [1122..1208] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle