YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ROX1

General Information:
Name(s) found: ROX1 / YPR065W [SGD]
Description(s) found:
SHOW ONLY BEST
  • gi|805045|emb|CAA89182.1| Rox1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6325322|ref|NP_015390.1| Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity; Rox1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4362|emb|CAA42991.1| ROX1 repressor [Saccharomyces cerevisiae] [NCBI NR]
  • gi|133277|sp|P25042.1|ROX1_YEAST RecName: Full=Repressor ROX1; AltName: Full=Hypoxic function repressor; AltName: Full=Heme-dependent repression factor [NCBI NR]
  • gi|1314133|emb|CAA94973.1| Rox1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||A54430 hypoxic function transcription repressor ROX1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Repressor ROX1 OS=Saccharomyces cerevisiae GN=ROX1 PE=1 SV=1 [Swiss-Prot]
  • ROX1 Heme-dependent transcriptional repressor of hypoxic genes [mips]
  • Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity [SGD]
  • (P25042) ROX1 repressor (Hypoxic function repressor) (Heme-dependent repression factor) [4932.FASTACCERV.txt]
  • Chr XVI from 679688-680794 [hmr_yeast5_DM3-1_pombe.fasta]
  • ROX1, Chr XVI from 679688-680794 [yeast_orfs2]
  • ROX1 SGDID:S0006269, Chr XVI from 679688-680794, Verified ORF [yeastflysequest.fasta]
  • ROX1 SGDID:S0006269, Chr XVI from 679690-680796, Verified ORF [10112005cervSGD.fasta]
  • Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity [Saccharomyces cerevisiae]gi|805045|emb|CAA89182.1| Rox1p [Saccharomyces cerevisiae]gi|4362|emb|CAA42991.1| ROX1 repressor [Saccharomyces cere [nrdb_11152004_Chlamydomonas]
  • ROX1 SGDID:S000006269, Chr XVI from 679690-680796, Verified ORF, "Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Rox1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Repressor ROX1 (Hypoxic function repressor) (Heme-dependent repression factor) [nr-271106-contam.fasta]
  • Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity; Rox1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ROX1 repressor [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Repressor ROX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ROX1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ROX1 SGDID:S000006269, Chr XVI from 679693-680799, Genome Release 64-1-1, Verified ORF, "Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity" [yeast-030211-contam.fasta]
  • ROX1 SGDID:S000006269, Chr XVI from 679693-680799, Genome Release 64-2-1, Verified ORF, "Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance" [20141208_orf_trans.fasta]
  • YPR065W SGDID:S000006269, Chr XVI from 679693-680799, Genome Release 64-1-1, Verified ORF, "Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 368 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromosome [IPILink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: DNA bending activity [IDALink to PubMed article]
    specific transcriptional repressor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPKSSTPKI PRPKNAFILF RQHYHRILID EWTAQGVEIP HNSNISKIIG TKWKGLQPED  60
   61 KAHWENLAEK EKLEHERKYP EYKYKPVRKS KKKQLLLKEI EQQQQQQQKE QQQQKQSQPQ 120
  121 LQQPFNNNIV LMKRAHSLSP SSSVSSSNSY QFQLNNDLKR LPIPSVNTSN YMVSRSLSGL 180
  181 PLTHDKTARD LPQLSSQLNS IPYYSAPHDP STRHHYLNVA QAQPRANSTP QLPFISSIIN 240
  241 NSSQTPVTTT TTSTTTATSS PGKFSSSPNS SVLENNRLNS INNSNQYLPP PLLPSLQDFQ 300
  301 LDQYQQLKQM GPTYIVKPLS HTRNNLLSTT TPTHHHIPHI PNQNIPLHQI INSSNTEVTA 360
  361 KTSLVSPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ESC1 ROX1 TAF2 TAF8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ROX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] PSI-BLAST 86.228787 Sox-2
    2 View Details [93..368] MSA 15.354997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA binding
    		•  5.15324651287773 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.01228762819617 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.9607192917135 bayes_pls_golite062009
  • transcription factor activity
    		•  3.82658263870186 bayes_pls_golite062009
  • binding
    		•  3.6211482127468 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.17018042329608 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.96229555092695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.75319687398598 bayes_pls_golite062009
  • chromatin binding
    		•  1.64428658020027 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62744929149746 bayes_pls_golite062009
  • protein binding
    		•  1.131658134984 bayes_pls_golite062009
  • transcription factor binding
    		•  1.10315330167937 bayes_pls_golite062009
  • DNA bending activity
    		•  0.87985209274756 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.4255419067266 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.261169200304829 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle