Protein Overview: HAA1

General Information:
Name(s) found:	HAA1 / YPR008W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|939742\|gb\|AAA97587.1\| Lpz8p [Saccharomyces cerevisiae] [NCBI NR] gi\|6325265\|ref\|NP_015333.1\| Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress; Haa1p [Saccharomyces cerevisiae] [NCBI NR] gi\|51013059\|gb\|AAT92823.1\| YPR008W [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S59753 hypothetical protein YPR008w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|17366444\|sp\|Q12753.1\|HAA1_YEAST RecName: Full=Transcriptional activator HAA1 [NCBI NR] gi\|1314083\|emb\|CAA95048.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] Transcriptional activator HAA1 OS=Saccharomyces cerevisiae GN=HAA1 PE=1 SV=1 [Swiss-Prot] HAA1 Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins [mips] Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress [SGD] (Q12753) Transcriptional activator HAA1 [4932.FASTACCERV.txt] Chr XVI from 573013-575097 [hmr_yeast5_DM3-1_pombe.fasta] HAA1, Chr XVI from 573013-575097 [yeast_orfs2] HAA1 SGDID:S0006212, Chr XVI from 573013-575097, Verified ORF [yeastflysequest.fasta] HAA1 SGDID:S0006212, Chr XVI from 573015-575099, Verified ORF [10112005cervSGD.fasta] Haa1p [Saccharomyces cerevisiae]gi\|51013059\|gb\|AAT92823.1\| YPR008W [Saccharomyces cerevisiae]gi\|1314083\|emb\|CAA95048.1\| unknown [Saccharomyces cerevisiae]gi\|17366444\|sp\|Q12753\|HAA1_YEAST Transcriptional activator HAA1gi\|2132257\|pir\|\|S59753 hypothetica [nrdb_11152004_Chlamydomonas] HAA1 SGDID:S000006212, Chr XVI from 573015-575099, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HAA1 SGDID:S000006212, Chr XVI from 573015-575099, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] HAA1 SGDID:S000006212, Chr XVI from 573015-575099, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress" [yeast-200209-contam.fasta] Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it is not subject to metalloregulation; Haa1p [Saccharomyces cerevis [nr-271106-contam.fasta] Lpz8p [nr-271106-contam.fasta] YPR008W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Transcriptional activator HAA1 [nr-271106-contam.fasta] HAA1 SGDID:S000006212, Chr XVI from 573015-575099, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; despite sequence similarity with the transcription factor Ace1p, it is not subject to metalloregulation" [yeast-contam_custom.fasta] [chemostatdb.fasta] Transcriptional activator HAA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAA1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HAA1 SGDID:S000006212, Chr XVI from 573018-575102, Genome Release 64-1-1, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress" [yeast-030211-contam.fasta] HAA1 SGDID:S000006212, Chr XVI from 573018-575102, Genome Release 64-2-1, Verified ORF, "Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress" [20141208_orf_trans.fasta] YPR008W SGDID:S000006212, Chr XVI from 573018-575102, Genome Release 64-1-1, Verified ORF, "Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	694 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA]
Biological Process:	transcription initiation from RNA polymerase II promoter [IDA]
Molecular Function:	specific RNA polymerase II transcription factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLINGIKYA CERCIRGHRV TTCNHTDQPL MMIKPKGRPS TTCDYCKQLR KNKNANPEGV  60
   61 CTCGRLEKKK LAQKAKEEAR AKAKEKQRKQ CTCGTDEVCK YHAQKRHLRK SPSSSQKKGR 120
  121 SISRSQPMFE RVLSSTSLDS NMLSGHGALS DTSSILTSTF LDSEPGVGKI SKDYHHVPSL 180
  181 ASISSLQSSQ SLDQNFSIPQ SPPLSSMSFN FLTGNINETN QNHSNHQHSK SGNNWQDSSV 240
  241 SLPAKADSRL NMMDKNNSVG LDLLGHSKRI SPISNSRVGE VSVPLEEYIP SDIDGVGRVT 300
  301 DKSSLVYDWP FDESIERNFS TTATAATGES KFDINDNCNR INSKSYSKTN SMNGNGMNNS 360
  361 NNNNINSNGN DKNNNNSSRQ EHQGNGLFDM FTDSSSISTL SRANLLLQEK IGSQENSVKQ 420
  421 ENYSKNPQLR HQLTSRSRSF IHHPANEYLK NTFGNSHSND IGKGVEVLSL TPSFMDIPEK 480
  481 ERETERSPSS NYITDRPFTR KPRSSSIDVN HRYPPMAPTT VATSPGALNN AVASNLDDQL 540
  541 SLTSLNSQPS SIANMMMDPS NLAEQSSIHS VPQSINSPRM PKTGSRQDKN IHTKKEERNP 600
  601 LNNIHDLSQL ENVPDEMNQM FSPPLKSMNR PDAIRENSSS SNFIIQGNSM ISTPSGRNDL 660
  661 PDTSPMSSIQ TASPPSQLLT DQGFADLDNF MSSL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		DRS1 ERB1 HAA1 HRQ1 MKT1 STE20 UBP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MSN5	HAA1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HAA1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..84]	PSI-BLAST	117.0	Zinc domain conserved in yeast copper-regulated transcription factors
2	View Details	[85..694]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
RNA polymerase II transcription factor activity	3.46199909835403	bayes_pls_golite062009
transcription regulator activity	3.44900037030135	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	2.99240619437226	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
ligand-regulated transcription factor activity	0.749213234767051	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2