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Protein Overview: GAL4

General Information:
Name(s) found: GAL4 / YPL248C [SGD]
Description(s) found:
Found 25 descriptions.
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  • DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 881 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: galactose metabolic process [IMPLink to PubMed article]
    positive regulation of transcription by galactose [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article]
    transcription activator activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLLSSIEQA CDICRLKKLK CSKEKPKCAK CLKNNWECRY SPKTKRSPLT RAHLTEVESR  60
   61 LERLEQLFLL IFPREDLDMI LKMDSLQDIK ALLTGLFVQD NVNKDAVTDR LASVETDMPL 120
  121 TLRQHRISAT SSSEESSNKG QRQLTVSIDS AAHHDNSTIP LDFMPRDALH GFDWSEEDDM 180
  181 SDGLPFLKTD PNNNGFFGDG SLLCILRSIG FKPENYTNSN VNRLPTMITD RYTLASRSTT 240
  241 SRLLQSYLNN FHPYCPIVHS PTLMMLYNNQ IEIASKDQWQ ILFNCILAIG AWCIEGESTD 300
  301 IDVFYYQNAK SHLTSKVFES GSIILVTALH LLSRYTQWRQ KTNTSYNFHS FSIRMAISLG 360
  361 LNRDLPSSFS DSSILEQRRR IWWSVYSWEI QLSLLYGRSI QLSQNTISFP SSVDDVQRTT 420
  421 TGPTIYHGII ETARLLQVFT KIYELDKTVT AEKSPICAKK CLMICNEIEE VSRQAPKFLQ 480
  481 MDISTTALTN LLKEHPWLSF TRFELKWKQL SLIIYVLRDF FTNFTQKKSQ LEQDQNDHQS 540
  541 YEVKRCSIML SDAAQRTVMS VSSYMDNHNV TPYFAWNCSY YLFNAVLVPI KTLLSNSKSN 600
  601 AENNETAQLL QQINTVLMLL KKLATFKIQT CEKYIQVLEE VCAPFLLSQC AIPLPHISYN 660
  661 NSNGSAIKNI VGSATIAQYP TLPEENVNNI SVKYVSPGSV GPSPVPLKSG ASFSDLVKLL 720
  721 SNRPPSRNSP VTIPRSTPSH RSVTPFLGQQ QQLQSLVPLT PSALFGGANF NQSGNIADSS 780
  781 LSFTFTNSSN GPNLITTQTN SQALSQPIAS SNVHDNFMNN EITASKIDDG NNSKPLSPGW 840
  841 TDQTAYNAFG ITTGMFNTTT MDDVYNYLFD DEDTPPNPKK E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GAL3 GAL4 GAL80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..65] PSI-BLAST 335.31133 Gal4; CD2-Gal4
    2 View Details [66..125] Pfam 18.958607 Gal4-like dimerisation domain No confident structure predictions are available.
    3 View Details [126..491] MSA 4.211986 View MSA. No confident structure predictions are available.
    4 View Details [492..597] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [598..881] MSA 11.100997 View MSA. No confident structure predictions are available.
    6 View Details [655..778] MSA 2.736996 View MSA. No confident structure predictions are available.
    7 View Details [779..881] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.03201524223606 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.86200506906385 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34861813464065 bayes_pls_golite062009
  • DNA binding
    		•  4.03985756894684 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.97978190843512 bayes_pls_golite062009
  • transcription factor activity
    		•  2.87348461329489 bayes_pls_golite062009
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.77469997789536 bayes_pls_golite062009
  • transcription activator activity
    		•  2.1512787242583 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.80191339934741 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.50774349911815 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle