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Protein Overview: MRN1

General Information:
Name(s) found: MRN1 / YPL184C [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 612 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVSYNNNNN NNNNNNNNNI SNNNNNNNMF PPFPSSDDFA MYQQSSSSGP YQETYASGPQ  60
   61 NFGDAVYPMN GNFTLLPSDF TREPNDSFFY ENDGIFDYQR IQQQPTQFQT KQRNDSQQQR 120
  121 FSQEQNFEID NEVVHNNNRY YEYERSSNEV SPFDDENPNV LSDGMSPTIM ATATAVTNAN 180
  181 APLPVNAQAN NPLNFTSAPS RTVYLGNVPP NLSVKELLDH VRSGVVEDVK IIPEKMCAFV 240
  241 SFIDESAALL FHSDAILKRL NIGDRDIKIG WGKPTRIDPI VAARISTDGA TRNVYIGRMT 300
  301 IEGEESHLSE EQLRVDLEEY GEIDCIKIIK EKGIAFIHFA SILNAIKVVT NLPIRNPYYQ 360
  361 NKRIFYGKDR CAFITKTQQH NAAQFLGVQP GMEHMIEFSD REFISNALLQ QSAAAAAIAT 420
  421 SAGGPNNLGN RTVYLGSLPK DVKIEEICNA VRGGLLQSIK LLNDRYVCFV TFIDPTAAAQ 480
  481 FYAMSSLYGF TVQKKRCKVG WGKHSGPLPN ALALAVSNGA SRNVYVGNID FVGDSLRDER 540
  541 VFTESNLRHI FQQYGEVEQI NFLPEKNCCF INYTNISNAI LALDKIKSNP YFKDLKINFG 600
  601 KDRCGNVPHQ SR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YPI1 MRN1 2 Hazbun TR, et al. (2003)
    View Screen HMT1 MRN1 1 Unpublished Fields Lab Data
    View Screen SNF1 MRN1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRN1 Huh WK, et al. (2003)

    User-submitted Microscopy Data:



      PROTEIN REFERENCE
    View Data MRN1 Düring L, Thorsen M, Petersen DSN, Køster B, Jensen TH, Holmberg S (2012) MRN1 Implicates Chromatin Remodeling Complexes and Architectural Factors in mRNA Maturation. PLoS ONE 7(9): e44373. doi:10.1371/journal.pone.0044373

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] MSA 5.350997 View MSA. No confident structure predictions are available.
    2 View Details [168..293] PSI-BLAST 55.09691 Poly(A)-binding protein
    3 View Details [294..402] PSI-BLAST 11.522879 Polypyrimidine tract-binding protein
    4 View Details [403..530] PSI-BLAST 11.522879 Polypyrimidine tract-binding protein
    5 View Details [531..612] PSI-BLAST 9.69897 Splicing factor U2AF 65 KDa subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • mRNA binding
    		•  2.76744192669109 bayes_pls_golite062009
  • RNA binding
    		•  2.41328743949172 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0829058000493267 bayes_pls_golite062009
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • mRNA binding
    		•  2.76744192669109 bayes_pls_golite062009
  • RNA binding
    		•  2.41328743949172 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0829058000493267 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle