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View Structure Prediction Details

Protein: MRN1
Organism: Saccharomyces cerevisiae
Length: 612 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MRN1.

Description E-value Query
Range		 Subject
Range
MRN1 - RNA-binding protein proposed to be involved in translational regulation; binds specific categories o...
gi|190407777 - gi|190407777|gb|EDV11042.1| RNA binding protein [Saccharomyces cerevisiae RM11-1a]
gi|151942615 - gi|151942615|gb|EDN60961.1| RNA binding protein [Saccharomyces cerevisiae YJM789]
MRN1_YEAST - RNA-binding protein MRN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRN1 PE=1 SV=1
 0.0 [1..612] [1..612]
gi|28918440, gi|... - gi|32411667|ref|XP_326314.1| hypothetical protein [Neurospora crassa], gi|28918440|gb|EAA28114.1| ne...
gi|85084632 - gi|85084632|ref|XP_957350.1| negative regulator of differentiation 1 [Neurospora crassa OR74A]
 6.0E-99 [6..612] [28..599]
PABPC4 - poly(A) binding protein, cytoplasmic 4 (inducible form)
 3.0E-97 [197..611] [7..379]
gi|31419252, gi|... - gi|41152034|ref|NP_958453.1| poly(A) binding protein, cytoplasmic 4 (inducible form) [Danio rerio], ...
 3.0E-93 [197..611] [8..380]
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
 8.0E-92 [193..611] [3..380]
gi|126540996, gi... - gi|22507391|ref|NP_683717.1| poly(A) binding protein, cytoplasmic 4 isoform 2 [Mus musculus], gi|163...
 1.0E-89 [197..611] [7..379]

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Predicted Domain #1
Region A:
Residues: [1-167] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVSYNNNNN NNNNNNNNNI SNNNNNNNMF PPFPSSDDFA MYQQSSSSGP YQETYASGPQ  60
   61 NFGDAVYPMN GNFTLLPSDF TREPNDSFFY ENDGIFDYQR IQQQPTQFQT KQRNDSQQQR 120
  121 FSQEQNFEID NEVVHNNNRY YEYERSSNEV SPFDDENPNV LSDGMSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [168-293] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIMATATAVT NANAPLPVNA QANNPLNFTS APSRTVYLGN VPPNLSVKEL LDHVRSGVVE  60
   61 DVKIIPEKMC AFVSFIDESA ALLFHSDAIL KRLNIGDRDI KIGWGKPTRI DPIVAARIST 120
  121 DGATRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.09691
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
mRNA binding 2.76744192669109 bayes_pls_golite062009
RNA binding 2.41328743949172 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [294-402] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VYIGRMTIEG EESHLSEEQL RVDLEEYGEI DCIKIIKEKG IAFIHFASIL NAIKVVTNLP  60
   61 IRNPYYQNKR IFYGKDRCAF ITKTQQHNAA QFLGVQPGME HMIEFSDRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1qm9A_
Description: Polypyrimidine tract-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.64594243387558 bayes_pls_golite062009
binding 3.00411894202318 bayes_pls_golite062009
mRNA binding 2.76744192669109 bayes_pls_golite062009
RNA binding 2.41328743949172 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 0.737458867828906 bayes_pls_golite062009
DNA binding 0.691258294213766 bayes_pls_golite062009
mRNA 3'-UTR binding 0.599389001184667 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009
structural molecule activity 0.0829058000493267 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [403-530] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FISNALLQQS AAAAAIATSA GGPNNLGNRT VYLGSLPKDV KIEEICNAVR GGLLQSIKLL  60
   61 NDRYVCFVTF IDPTAAAQFY AMSSLYGFTV QKKRCKVGWG KHSGPLPNAL ALAVSNGASR 120
  121 NVYVGNID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1qm9A_
Description: Polypyrimidine tract-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [531-612] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVGDSLRDER VFTESNLRHI FQQYGEVEQI NFLPEKNCCF INYTNISNAI LALDKIKSNP  60
   61 YFKDLKINFG KDRCGNVPHQ SR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1o0pA_
Description: Splicing factor U2AF 65 KDa subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle