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Protein Overview: ATG21

General Information:
Name(s) found: ATG21 / YPL100W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: vacuolar protein processing [IMPLink to PubMed article]
    autophagy [IGILink to PubMed article][IMPLink to PubMed article]
    CVT pathway [IMPLink to PubMed article]
    Molecular Function: phosphoinositide binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVLQFNQDA TCCVVAASSH QISIFNCDPF GKCFEIDTKN SKKKTSNNNG SASNSESRNN  60
   61 EESILITNGS RDRTDAEEEE DNEDNALVTG NILKEGEFVI EMLFSTSLIA IADRGQGLNK 120
  121 GKKLKIVNTK RKCTICEIVF PHEIVDVVMN RKRMCVLLES DQIFIYDISC MKPLETIDLW 180
  181 EDHYKRSQAN SFSNASNTGT LEGDSANLNR VATNLLANAT QKSVNGSNPS VRTRRNSLRS 240
  241 KIRPRMVLSN DDRSILCFTA YSSPKKNKPN SEALYDVVIY DTLNVTPVNY LNSVHKGNVA 300
  301 CLAVSHDGKL LATASDKGTI IRVFHTGVDS DYMSSRSLFK EFRRGTRLCN LYQLAFDKSM 360
  361 TMIGCVGDTD TIHLFKLDDA SNSLPGDNSS NGHWNEEEYI LASNSNPSMG TPKEIPLSKP 420
  421 RIANYFSKKI KSSIPNQNLS RNFAYITVNE SNRSCLGFPD EFPNQVYIAS DDGTFSIYSI 480
  481 PSKPGECVLT KNNKFT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ATG18 ATG21 VAM7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ATG21 and SNF7 Huh WK, et al. (2003)
    View Data ATG21 Huh WK, et al. (2003)
    View Data ATG21 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..366] PSI-BLAST 38.522879 Cdc4 F-box and linker domains; Cdc4 propeller domain
    2 View Details [367..423] PSI-BLAST 16.30103 Arp2/3 complex 41 kDa subunit ARPC1
    3 View Details [424..496] PSI-BLAST 63.0 Tup1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle