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Protein Overview: PNG1

General Information:
Name(s) found: PNG1 / YPL096W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 363 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed articleLink to PubMed article]
    Biological Process: protein deglycosylation [IDALink to PubMed article]
    misfolded or incompletely synthesized protein catabolic process [IMPLink to PubMed article]
    Molecular Function: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEVYEKNNI DFDSIAKMLL IKYKDFILSK FKKAAPVENI RFQNLVHTNQ FAQGVLGQSQ  60
   61 HLCTVYDNPS WHSIVLETLD LDLIYKNVDK EFAKDGHAEG ENIYTDYLVK ELLRYFKQDF 120
  121 FKWCNKPDCN HCGQNTSENM TPLGSQGPNG EESKFNCGTV EIYKCNRCGN ITRFPRYNDP 180
  181 IKLLETRKGR CGEWCNLFTL ILKSFGLDVR YVWNREDHVW CEYFSNFLNR WVHVDSCEQS 240
  241 FDQPYIYSIN WNKKMSYCIA FGKDGVVDVS KRYILQNELP RDQIKEEDLK FLCQFITKRL 300
  301 RYSLNDDEIY QLACRDEQEQ IELIRGKTQE TKSESVSAAS KSSNRGRESG SADWKAQRGE 360
  361 DGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PNG1 RAD23
    View Details Krogan NJ, et al. (2006) PNG1 RAD23

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PNG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] MSA 1.054988 View MSA. No confident structure predictions are available.
    2 View Details [134..277] Pfam 15.443697 Transglutaminase-like superfamily No confident structure predictions are available.
    3 View Details [278..363] MSA 2.128995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity
    		•  2.99092799770282 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.70509346529146 bayes_pls_golite062009
  • binding
    		•  2.49172648273202 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.90904708303381 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.64915398352449 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  1.44953547163733 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38318152877128 bayes_pls_golite062009
  • peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
    		•  1.3714358594696 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.34325826373515 bayes_pls_golite062009
  • DNA binding
    		•  1.31096468235949 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.28746642057417 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.774177093888744 bayes_pls_golite062009
  • transcription factor activity
    		•  0.656405451523439 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.218846845851145 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle