Protein Overview: DCI1

General Information:
Name(s) found:	DCI1 / YOR180C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed [SGD]
Organism:	Saccharomyces cerevisiae
Length:	271 amino acids
Gene Ontology:
Cellular Component:	peroxisomal matrix [IDA]
Biological Process:	fatty acid beta-oxidation [TAS]
Molecular Function:	dodecenoyl-CoA delta-isomerase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRVCYHIN GPFFIIKLID PKHLNSLTFE DFVYIALLLH KANDIDSVLF TVLQSSGKYF  60
   61 SSGGKFSAVN KLNDGDVTSE VEKVSKLVSA ISSPNIFVAN AFAIHKKVLV CCLNGPAIGL 120
  121 SASLVALCDI VYSQNDSVFL LFPFSNLGFV AEVGTSVTLT QKLGINSANE HMIFSTPVLF 180
  181 KELIGTIITK NYQLTNTETF NEKVLQDIKQ NLEGLYPKSV LGMKELLHSE MKQKLIKAQA 240
  241 METNGTLPFW ASGEPFKRFK QLQEGNRRHK L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		DCI1 ECI1 FOX2 MDH3 POT1 POX1 TES1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PDI1	DCI1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..271]	PSI-BLAST	713.529817	Dienoyl-CoA isomerase (delta3-delta2-enoyl-CoA isomerase)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
3-hydroxyacyl-CoA dehydrogenase activity	4.25084649365698	bayes_pls_golite062009
CoA carboxylase activity	3.59076614105466	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.34692152434862	bayes_pls_golite062009
enoyl-CoA hydratase activity	3.27044058633674	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	1.97586838275054	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	1.31614278936637	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	1.08284170936757	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
propionyl-CoA carboxylase activity	0.2998946244546	bayes_pls_golite062009
binding	0.222808057179506	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.61

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2