Protein Overview: KTR1

General Information:
Name(s) found:	KTR1 / YOR099W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324673\|ref\|NP_014742.1\| Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; Ktr1p [Saccharomyces cerevisiae] [NCBI NR] gi\|3866\|emb\|CAA44713.1\| KTR1 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S61659 KTR1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420277\|emb\|CAA99296.1\| KTR1 [Saccharomyces cerevisiae] [NCBI NR] gi\|125725\|sp\|P27810.1\|KTR1_YEAST RecName: Full=Alpha-1,2 mannosyltransferase KTR1 [NCBI NR] gi\|1164946\|emb\|CAA64021.1\| YOR3189w [Saccharomyces cerevisiae] [NCBI NR] Alpha-1,2 mannosyltransferase KTR1 OS=Saccharomyces cerevisiae GN=KTR1 PE=1 SV=1 [Swiss-Prot] KTR1 Mannosyltransferase involved in n-linked and o-linked glycosylation [mips] Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family [SGD] (P27810) Alpha-1,2 mannosyltransferase KTR1 (EC 2.4.1.131) [4932.FASTACCERV.txt] Chr XV from 511825-513006 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 511824-513005 [yeastorf3.fasta] KTR1, Chr XV from 511824-513005 [yeast_orfs2] KTR1 SGDID:S0005625, Chr XV from 511825-513006, Verified ORF [yeastflysequest.fasta] Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Saccharomyces cerevisiae]gi\|1420277\|emb\|CAA99296.1\| KTR1 [Saccharomyces cerevisiae]gi\|1164946\|emb\|CAA64021.1\| YOR3189w [ [nrdb_11152004_Chlamydomonas] KTR1 SGDID:S000005625, Chr XV from 511825-513006, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] KTR1 SGDID:S000005625, Chr XV from 511826-513007, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family" [yeast-contam.fasta] KTR1 SGDID:S000005625, Chr XV from 511826-513007, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] KTR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Ktr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Alpha-1,2 mannosyltransferase KTR1 [nr-271106-contam.fasta] YOR3189w [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Alpha-1,2 mannosyltransferase KTR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KTR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] KTR1 SGDID:S000005625, Chr XV from 511825-513006, Genome Release 64-1-1, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family" [yeast-030211-contam.fasta] KTR1 SGDID:S000005625, Chr XV from 511825-513006, Genome Release 64-2-1, Verified ORF, "Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta] TR4971\|c0_g1_i1\|g.3490 ORF TR4971\|c0_g1_i1\|g.3490 TR4971\|c0_g1_i1\|m.3490 type:complete len:394 (+) TR4971\|c0_g1_i1:204-1385(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YOR099W SGDID:S000005625, Chr XV from 511825-513006, Genome Release 64-1-1, Verified ORF, "Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_2396\|g.2052 ORF asmbl_2396\|g.2052 asmbl_2396\|m.2052 type:complete len:394 (+) asmbl_2396:208-1389(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_2399\|g.1573 ORF ID=asmbl_2399\|g.1573 ID=asmbl_2399\|m.1573 type:complete len:394 (+) ID=asmbl_2399:208-1389(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	393 amino acids
Gene Ontology:
Cellular Component:	Golgi apparatus [IDA]
Biological Process:	cell wall mannoprotein biosynthetic process [IMP] protein amino acid O-linked glycosylation [IMP] N-glycan processing [IMP]
Molecular Function:	alpha-1,2-mannosyltransferase activity [IDA][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKIMIPASK QPVYKKLGLL LVAVFTVYVF FHGAQYARGS APSPKYSTVL SSGSGYKYSK  60
   61 VELPKYTGPR EKATFVTLVR NRDLYSLAES IKSVEDRFNS KFNYDWVFLN DEEFTDEFKN 120
  121 VTSALVSGTT KYGVIPKEHW SFPEWIDEEK AAQVRKEMGE KRIIYGDSIS YRHMCRFESG 180
  181 FFYRHPLMDD YDWYWRVEPD IKLHCDIDYD VFKFMKDNKK KYAFAISIKE YEATIPTLWE 240
  241 TTRKFMEAHP ELIHENNMLD FVSDDQGLSY NLCHFWSNFE IAALDLWRSP AYSAYFDYLD 300
  301 REGGFFYERW GDAPVHSIGA ALFLDRSEIH HFGDIGYYHV PFHSCPIDTS IRLANKCDCD 360
  361 PSKDFTWHSY SCTTKFYNIN KLPKPAGWQN HIG

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		GNT1 KRE2 KTR1 MNN1 MNN5 MNN9 VAN1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX11 - both fusion and trans-SNARE complex formation take place.	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control).	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBI4	KTR1	1	Unpublished Fields Lab Data
View Screen	RRB1	KTR1	1	Unpublished Fields Lab Data
View Screen	SPO1	KTR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	KTR1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..393]	Pfam	235.022276	Glycolipid 2-alpha-mannosyltransferase No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
alpha-1,2-mannosyltransferase activity	6.0576932895264	bayes_pls_golite062009
mannosyltransferase activity	5.57855076532185	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	4.49413422196176	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	4.37944217610823	bayes_pls_golite062009
UDP-glycosyltransferase activity	4.08451171179562	bayes_pls_golite062009
acetylgalactosaminyltransferase activity	3.4614674054855	bayes_pls_golite062009
transferase activity	3.32517438937547	bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity	3.19923094610567	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.51696952719873	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
nucleotidyltransferase activity	1.86990263440735	bayes_pls_golite062009
uridylyltransferase activity	1.27888067902271	bayes_pls_golite062009
binding	0.948692623641759	bayes_pls_golite062009
glucuronosyltransferase activity	0.36353543999278	bayes_pls_golite062009
protein binding	0.124656890356575	bayes_pls_golite062009
UDP-galactosyltransferase activity	0.10185872015123	bayes_pls_golite062009
galactosyltransferase activity	0.0931461042017721	bayes_pls_golite062009
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	0.0339369954475406	bayes_pls_golite062009
acetylglucosaminyltransferase activity	0.0278258721775009	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2