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Protein Overview: KTR1

General Information:
Name(s) found: KTR1 / YOR099W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [IDALink to PubMed article]
    Biological Process: cell wall mannoprotein biosynthetic process [IMPLink to PubMed article]
    protein amino acid O-linked glycosylation [IMPLink to PubMed article]
    N-glycan processing [IMPLink to PubMed article]
    Molecular Function: alpha-1,2-mannosyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKIMIPASK QPVYKKLGLL LVAVFTVYVF FHGAQYARGS APSPKYSTVL SSGSGYKYSK  60
   61 VELPKYTGPR EKATFVTLVR NRDLYSLAES IKSVEDRFNS KFNYDWVFLN DEEFTDEFKN 120
  121 VTSALVSGTT KYGVIPKEHW SFPEWIDEEK AAQVRKEMGE KRIIYGDSIS YRHMCRFESG 180
  181 FFYRHPLMDD YDWYWRVEPD IKLHCDIDYD VFKFMKDNKK KYAFAISIKE YEATIPTLWE 240
  241 TTRKFMEAHP ELIHENNMLD FVSDDQGLSY NLCHFWSNFE IAALDLWRSP AYSAYFDYLD 300
  301 REGGFFYERW GDAPVHSIGA ALFLDRSEIH HFGDIGYYHV PFHSCPIDTS IRLANKCDCD 360
  361 PSKDFTWHSY SCTTKFYNIN KLPKPAGWQN HIG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GNT1 KRE2 KTR1 MNN1 MNN5 MNN9 VAN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KTR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] Pfam 235.022276 Glycolipid 2-alpha-mannosyltransferase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • alpha-1,2-mannosyltransferase activity
    		•  6.0576932895264 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  5.57855076532185 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  4.49413422196176 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  4.37944217610823 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  4.08451171179562 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  3.4614674054855 bayes_pls_golite062009
  • transferase activity
    		•  3.32517438937547 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  3.19923094610567 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.51696952719873 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.86990263440735 bayes_pls_golite062009
  • uridylyltransferase activity
    		•  1.27888067902271 bayes_pls_golite062009
  • binding
    		•  0.948692623641759 bayes_pls_golite062009
  • glucuronosyltransferase activity
    		•  0.36353543999278 bayes_pls_golite062009
  • protein binding
    		•  0.124656890356575 bayes_pls_golite062009
  • UDP-galactosyltransferase activity
    		•  0.10185872015123 bayes_pls_golite062009
  • galactosyltransferase activity
    		•  0.0931461042017721 bayes_pls_golite062009
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    		•  0.0339369954475406 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.0278258721775009 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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